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Article
Open AccessThe sequence and de novo assembly of the giant panda genome
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% o...
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Article
Salvianolic acid A inhibits angiotensin II-induced proliferation of human umbilical vein endothelial cells by attenuating the production of ROS
To investigate the action of salvianolic acid A (SalA) on angiotensin II (Ang II)-induced proliferation of human umbilical vein endothelial cells (HUVECs) and the possible signaling pathways mediating this act...
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Article
Open AccessTGF beta1 and related-Smads contribute to pulmonary metastasis of hepatocellular carcinoma in mice model
Recent studies indicate that Transforming Growth Factor beta (TGF β) correlated with pulmonary metastasis of cancers. However, the correlation between TGF β and pulmonary metastasis of hepatocellular carcinoma...
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Article
Open AccessSearch for direct chargino production in anomaly-mediated supersymmetry breaking models based on a disappearing-track signature in pp collisions at \( \sqrt{s}=7\;\mathrm{TeV} \) with the ATLAS detector
A search for direct chargino production in anomaly-mediated supersymmetry breaking scenarios is performed in pp collisions at \( \sqrt{s}=7\;\mathrm{TeV} \) using 4.7 fb−1 of data co...
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Article
Open AccessGene-guided Gefitinib switch maintenance therapy for patients with advanced EGFR mutation-positive Non-small cell lung cancer: an economic analysis
Maintenance therapy with gefitinib notably improves survival in patients with advanced non-small cell lung cancer (NSCLC) and EGFR mutation-positive tumors, but the economic impact of this practice is unclear.
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Article
Open AccessGenome of the Chinese tree shrew
Chinese tree shrews (Tupaia belangeri chinensis) possess many features valuable in animals used as experimental models in biomedical research. Currently, there are numerous attempts to employ tree shrews as model...
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Article
Open AccessMembrane Type 1 Matrix Metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells
Tissue invasion and metastasis are acquired abilities of cancer and related to the death in oral squamous cell carcinoma (OSCC). Emerging observations indicate that the epithelial-to-mesenchymal transition (EM...
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Article
Open AccessSearch for dark matter candidates and large extra dimensions in events with a jet and missing transverse momentum with the ATLAS detector
A search for new phenomena in events with a high-energy jet and large missing transverse momentum is performed using data from proton-proton collisions at ...
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Article
Open AccessB-cell lymphoma 6 protein stimulates oncogenicity of human breast cancer cells
B-cell lymphoma 6 (BCL6) protein, an evolutionarily conserved zinc finger transcription factor, showed to be highly expressed in various human cancers in addition to malignancies in the lymphoid system. This s...
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Article
Open AccessMetabolic syndrome and renal cell carcinoma
Metabolic syndrome (MS) is a cluster of metabolic abnormalities, which has been regarded as a pivotal risk factor for cardiovascular diseases. Recent studies focusing on the relationship between MS and cancer ...
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Article
Open AccessThe Physics of the B Factories
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Open AccessFingerprint analysis of processed Rhizoma Chuanxiong by high-performance liquid chromatography coupled with diode array detection
Rhizoma Chuanxiong (RC) is the dried rhizome of Ligusticum chuanxiong Hort., and various types of processed Rhizoma Chuanxiong (PRC) are widely used in China. However, quality assurance and quality control of the...
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Article
Open AccessDispersionless Manipulation of Reflected Acoustic Wavefront by Subwavelength Corrugated Surface
Free controls of optic/acoustic waves for bending, focusing or steering the energy of wavefronts are highly desirable in many practical scenarios. However, the dispersive nature of the existing metamaterials/m...
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Open AccessIGF-1 decreases portal vein endotoxin via regulating intestinal tight junctions and plays a role in attenuating portal hypertension of cirrhotic rats
Intestinal barrier dysfunction is not only the consequence of liver cirrhosis, but also an active participant in the development of liver cirrhosis. Previous studies showed that external administration of insu...
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Open AccessWhole Exome Sequencing Identifies Frequent Somatic Mutations in Cell-Cell Adhesion Genes in Chinese Patients with Lung Squamous Cell Carcinoma
Lung squamous cell carcinoma (SQCC) accounts for about 30% of all lung cancer cases. Understanding of mutational landscape for this subtype of lung cancer in Chinese patients is currently limited. We performed...
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Article
Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Open AccessA new prognostic histopathologic classification of nasopharyngeal carcinoma
The current World Health Organization (WHO) classification of nasopharyngeal carcinoma (NPC) conveys little prognostic information. This study aimed to propose an NPC histopathologic classification that can po...
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Article
Open AccessMicroRNA-29c-5p suppresses gallbladder carcinoma progression by directly targeting CPEB4 and inhibiting the MAPK pathway
Gallbladder cancer (GBC) is a leading cause of cancer-related deaths worldwide, and its prognosis remains poor, with a 5-year survival rate of ~5%. Given the crucial role of microRNAs (miRNAs) in cancer metast...
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Article
Open AccessComparison of chemical profiles between the root and aerial parts from three Bupleurum species based on a UHPLC-QTOF-MS metabolomics approach
Bupleuri Radix (Chaihu) represents one of the most successful and widely used herbal medicines in Asia for the treatment of many diseases such as inflammatory disorders and infectious diseases over the past 20...
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Open AccessUpdating the Geologic Barcodes for South China: Discovery of Late Archean Banded Iron Formations in the Yangtze Craton
Banded iron formations (BIFs) in Archean cratons provide important “geologic barcodes” for the global correlation of Precambrian sedimentary records. Here we report the first finding of late Archean BIFs from ...
