15 Result(s)

Article

Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies

Bietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is no clinical therapy approach available for BCD patients. Previous resear...

Chang Shen, Qianjie Yang, Kuangqi Chen, Huiling Ma… in Cell Communication and Signaling (2024)

Article

Methylation in cornea and corneal diseases: a systematic review

Corneal diseases are among the primary causes of blindness and vision loss worldwide. However, the pathogenesis of corneal diseases remains elusive, and diagnostic and therapeutic tools are limited. Thus, iden...

Yutong **a, Kuangqi Chen, Qianjie Yang, Zhitong Chen, Le **… in Cell Death Discovery (2024)

Article

Retraction Note: Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5

Bing Wang, Xuezhi Hao, **ngkai Li, Yicheng Liang, Fang Li, Kun Yang… in Cell Death & Disease (2023)

Article

Single-cell RNA sequencing in cancer research: discovering novel biomarkers and therapeutic targets for immune checkpoint blockade

Immune checkpoint blockade (ICB) has become a promising strategy in treating advanced cancers, providing significant survival benefits for patients with various cancer types. However, among the vast population...

Boyu Sun, Ziyu Xun, Nan Zhang, Kai Liu, **angqi Chen… in Cancer Cell International (2023)

Article

Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy

In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly inhibits the AKT signaling pathway by increasing oxidative stress or inhibiting growth factor expression, which leads t...

Jiayuan Li, Kuangqi Chen, **ang Li, Xuhong Zhang, Liyue Zhang… in Cell Death Discovery (2023)

Article

Identification of ATF3 as a novel protective signature of quiescent colorectal tumor cells

Colorectal cancer (CRC) is the third most common cancer and the second leading cause of death in the world. In most cases, drug resistance and tumor recurrence are ultimately inevitable. One obstacle is the pr...

** Lu, Lei Zhong, Emma Lindell, Margus Veanes, **g Guo, Miao Zhao… in Cell Death & Disease (2023)

Article

Comprehensive landscape of resistance mechanisms for neoadjuvant therapy in esophageal squamous cell carcinoma by single-cell transcriptomics

Yushang Yang, Yanguo Li, Haopeng Yu… in Signal Transduction and Targeted Therapy (2023)

Article

MMP2 is a immunotherapy related biomarker and correlated with cancer-associated fibroblasts infiltrate in melanoma

Mounting evidence supports that matrix metalloproteinase (MMPs) are highly associated with tumor progression and that targeting MMPs may overcome the barrier of immune suppression. Among these, whether MMP2 fu...

Kunwei Peng, Yanyan Zhang, Deyi Liu, **gqi Chen in Cancer Cell International (2023)

Article

The role of the PI3K/AKT signalling pathway in the corneal epithelium: recent updates

Phosphatidylinositol 3 kinase (PI3K)/AKT (also called protein kinase B, PKB) signalling regulates various cellular processes, such as apoptosis, cell proliferation, the cell cycle, protein synthesis, glucose m...

Kuangqi Chen, Yanqing Li, Xuhong Zhang, Rahim Ullah, Jian** Tong… in Cell Death & Disease (2022)

Article

Endoplasmic reticulum stress promotes the release of exosomal PD-L1 from head and neck cancer cells and facilitates M2 macrophage polarization

Endoplasmic reticulum (ER) stress has been found to foster the escape of cancer cells from immune surveillance and upregulate PD-L1 expression. However, the underlying mechanisms are unknown.

Yi Yuan, Pengfei Jiao, Zeyu Wang, Mengqi Chen… in Cell Communication and Signaling (2022)

Article

Interleukin-22 and connective tissue diseases: emerging role in pathogenesis and therapy

Interleukin-22 (IL-22), a member of the IL-10 family of cytokines, is produced by a number of immune cells involved in the immune microenvironment of the body. IL-22 plays its pivotal roles by binding to the I...

**uyun Xuan, Lin Zhang, Chunxia Tian, Ting Wu, Haihua Ye, Juanmei Cao… in Cell & Bioscience (2021)

Article

RETRACTED ARTICLE: Long noncoding RNA HEIH depletion depresses esophageal carcinoma cell progression by upregulating microRNA-185 and downregulating KLK5

Numerous studies have reported the association of long non-coding RNAs (lncRNAs) in cancers, yet the function of lncRNA high expressed in hepatocellular carcinoma (HEIH) in esophageal carcinoma (EC) has seldom...

Bing Wang, Xuezhi Hao, **ngkai Li, Yicheng Liang, Fang Li, Kun Yang… in Cell Death & Disease (2020)

Article

ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer

The Serine–Glycine–One-Carbon (SGOC) pathway is pivotal in multiple anabolic processes. Expression levels of SGOC genes are deregulated under tumorigenic conditions, suggesting participation of oncogenes in de...

Kai Li, Jian-lin Wu, Baifu Qin, Zongmin Fan, Qin Tang, Weisi Lu… in Cell Research (2020)

Article

Neutrophil extracellular traps induced by VP1 contribute to pulmonary edema during EV71 infection

Pulmonary edema is a fatal complication of EV71-associated hand, foot, and mouth disease (HFMD). The pathogenesis of EV71-induced pulmonary edema remains largely unclear. In this study, we aimed to explore the...

Nan Wang, **aofan Yang, Jiandong Sun, Zhixiao Sun, Qiyun Ma… in Cell Death Discovery (2019)

Article

TRIP13 promotes tumor growth and is associated with poor prognosis in colorectal cancer

Colorectal cancer (CRC) is one of the most common neoplasms worldwide. However, the mechanisms underlying its development are still poorly understood. Thyroid hormone Receptor Interactor 13 (TRIP13) is a key m...

Nengquan Sheng, Li Yan, Kai Wu, Weiqiang You, Jianfeng Gong… in Cell Death & Disease (2018)