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    The E50K optineurin mutation impacts autophagy-mediated degradation of TDP-43 and leads to RGC apoptosis in vivo and in vitro

    The glaucoma-associated E50K mutation in optineurin (OPTN) is known to affect autophagy and cause the apoptosis of retinal ganglion cells (RGCs), but the pathogenic mechanism remains unclear. In this study, we...

    Shiqi Zhang, Zhengbo Shao, **nna Liu, Mingying Hou, Fang Cheng… in Cell Death Discovery (2021)

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