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  1. No Access

    Article

    Transforming toxins into treatments: the revolutionary role of α-amanitin in cancer therapy

    Amanita phalloides is the primary species responsible for fatal mushroom poisoning, as its main toxin, α-amanitin, irreversibly and potently inhibits eukaryotic RNA polymerase II (RNAP II), leading to cell death....

    Deyuan Ning, **fang Xue, **ran Lou, Ruifei Shao, Yu Liu… in Archives of Toxicology (2024)

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    Article

    ZFX-mediated upregulation of CEBPA-AS1 contributes to acute myeloid leukemia progression through miR-24-3p/CTBP2 axis

    Emerging reports demonstrated that long non-coding RNAs (lncRNAs) play a role in the pathogenesis and metastasis of cancers. However, the biological functions and underlying mechanisms of LncRNA CEBPA-AS1 in a...

    Chengyi Wang, Chao-Min Song, Shan Liu, Lu-Min Chen… in Cell Biology and Toxicology (2023)

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    Mechanism and treatment of α-amanitin poisoning

    Amanita poisoning has a high mortality rate. The α-amanitin toxin in Amanita is the main lethal toxin. There is no specific detoxification drug for α-amanitin, and the clinical treatment mainly focuses on symp...

    **fang Xue, **ran Lou, Deyuan Ning, Ruifei Shao, Guobing Chen in Archives of Toxicology (2023)

  4. Article

    Review: the role of GSDMD in sepsis

    Gasdermin D (GSDMD) is a cytoplasmic protein that is encoded by the gasdermin family GSDMD gene and is the ultimate executor of pyroptosis. Pyroptosis is a mode of lysis and inflammation that regulates cell de...

    Ruifei Shao, **ran Lou, **fang Xue, Deyuan Ning, Guobing Chen… in Inflammation Research (2022)

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