5 Result(s)
within
Life Sciences
Biochemistry, general
**ao-wan Wang
Article
-
Article
Open AccessmiR-425 deficiency promotes necroptosis and dopaminergic neurodegeneration in Parkinson’s disease
A major hallmark of Parkinson’s disease (PD) is the degeneration of dopaminergic neurons in the substantia nigra, and the causative mechanism is thought to be the activation of programmed neuronal death. Necro...
-
Article
Open AccessADGRA1 negatively regulates energy expenditure and thermogenesis through both sympathetic nervous system and hypothalamus–pituitary–thyroid axis in male mice
Adhesion G protein-coupled receptor A1 (ADGRA1, also known as GPR123) belongs to the G protein-coupled receptors (GPCRs) family and is well conserved in the vertebrate lineage. However, the structure of ADGRA1...
-
Article
Open AccessLoss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer’s disease
Iron homeostasis disturbance has been implicated in Alzheimer’s disease (AD), and excess iron exacerbates oxidative damage and cognitive defects. Ferroptosis is a nonapoptotic form of cell death dependent upon...
-
Article
Open AccessPINK1 kinase dysfunction triggers neurodegeneration in the primate brain without impacting mitochondrial homeostasis
In vitro studies have established the prevalent theory that the mitochondrial kinase PINK1 protects neurodegeneration by removing damaged mitochondria in Parkinson’s disease (PD). However, difficulty in detecting...
-
Article
Open AccessAcinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development
Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...
