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The mechanisms and possible significance of upregulation of stomatin expression by hypoxia and/or glucocorticoids
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Erratum to: “High level secretory expression of murine OCIL by CHO cells and action of OCIL on osteoclast differentiation”
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Open AccessSilicon-mediated amelioration of zinc toxicity in rice (Oryza sativa L.) seedlings
Silicon (Si) was suggested to enhance plant resistance to toxic elements, and its beneficial role was mainly based on external and internal plant mechanisms. This work aimed at investigating the internal effec...
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Open AccessIdentification and analysis of MKK and MPK gene families in canola (Brassica napusL.)
Eukaryotic mitogen-activated protein kinase (MAPK/MPK) signaling cascades transduce and amplify environmental signals via three types of reversibly phosphorylated kinases to activate defense gene expression. C...
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Open AccessComparative transcriptome analysis of tomato (Solanum lycopersicum) in response to exogenous abscisic acid
Abscisic acid (ABA) can regulate the expressions of many stress-responsive genes in plants. However, in defense responses to pathogens, mounting evidence suggests that ABA plays variable roles. Little informat...
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Open AccessMammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase
The methyltransferase like 3 (METTL3)-containing methyltransferase complex catalyzes the N6-methyladenosine (m6A) formation, a novel epitranscriptomic marker; however, the nature of this complex remains largel...
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Open AccessPhylogenetic assessment of Chaetomium indicum and allied species, with the introduction of three new species and epitypification of C. funicola and C. indicum
Historically, the Chaetomium indicum group contained six species with similar ascus and ascospore morphology. Large morphological variation in their branched ascomatal hairs often resulted in ambiguous species de...
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Open AccessGenomes of the rice pest brown planthopper and its endosymbionts reveal complex complementary contributions for host adaptation
The brown planthopper, Nilaparvata lugens, the most destructive pest of rice, is a typical monophagous herbivore that feeds exclusively on rice sap, which migrates over long distances. Outbreaks of it have re-occ...
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Open AccessConstruction of a high-density genetic map and QTLs map** for sugars and acids in grape berries
QTLs controlling individual sugars and acids (fructose, glucose, malic acid and tartaric acid) in grape berries have not yet been identified. The present study aimed to construct a high-density, high-quality g...
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Open AccessGenome-wide characterization of developmental stage- and tissue-specific transcription factors in wheat
Wheat (Triticum aestivum) is one of the most important cereal crops, providing food for humans and feed for other animals. However, its productivity is challenged by various biotic and abiotic stresses such as fu...
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Open AccessRecurrent gain-of-function USP8 mutations in Cushing's disease
Cushing's disease, also known as adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (PAs) that cause excess cortisol production, accounts for up to 85% of corticotrophin-dependent Cushing's syndro...
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Open AccessHuman adipose-derived stem cells partially rescue the stroke syndromes by promoting spatial learning and memory in mouse middle cerebral artery occlusion model
Growing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of...
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Open AccessGenome-wide analysis of the gene families of resistance gene analogues in cotton and their response to Verticillium wilt
Gossypium raimondii is a Verticillium wilt-resistant cotton species whose genome encodes numerous disease resistance genes that play important roles in the defence against pathogens. However, t...
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Open AccessPhylodynamic reconstruction of the spatiotemporal transmission and demographic history of coxsackievirus B2
Studies regarding coxsackievirus (CV) tend to focus on epidemic outbreaks, an imbalanced topology is considered to be an indication of acute infection with partial cross-immunity. In enteroviruses, a clear und...
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Open AccessOverexpression of the MYB37 transcription factor enhances abscisic acid sensitivity, and improves both drought tolerance and seed productivity in Arabidopsis thaliana
Although a lot of genes have been revealed to participate in abscisic acid (ABA) signaling, many of the additional components involved in ABA signaling remain to be discovered. Here we report that overexpressi...
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Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome
PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ...
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Open AccessMelatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway
Oesophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-associated death in the world and novel therapeutic alternatives are urgently warranted. In this study, we investigated the a...
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Open AccessEZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells
Lidamycin (LDM) is a novel member of the enediyne antibiotics identified in China with potent antitumor activity. However, it remains unclear whether LDM has potential molecular targets that may affect its ant...
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Open AccessThe protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression
The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a seri...
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Cytoplasmic m6A reader YTHDF3 promotes mRNA translation