88 Result(s)
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**ao-Yan Bai
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Open AccessTargeting the PI3K/AKT/mTOR pathway offer a promising therapeutic strategy for cholangiocarcinoma patients with high doublecortin-like kinase 1 expression
Cholangiocarcinoma (CCA), characterized by high heterogeneity and extreme malignancy, has a poor prognosis. Doublecortin-like kinase 1 (DCLK1) promotes a variety of malignant cancers in their progression. Targ...
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Pan-drug resistance and hypervirulence in a human fungal pathogen are enabled by mutagenesis induced by mammalian body temperature
The continuing emergence of invasive fungal pathogens poses an increasing threat to public health. Here, through the China Hospital Invasive Fungal Surveillance Net programme, we identified two independent cas...
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Open AccessA gamepad-like nucleic acid testing device for rapid detection of SARS-CoV-2 via visible nested recombinase polymerase amplification
Nucleic acid tests are essential for the accurate diagnosis and control of infectious diseases. However, current assays are not easily scalable for a large population, due to the requirement of laboratory sett...
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Efficient ethylene electrosynthesis through C–O cleavage promoted by water dissociation
Electrochemical reduction of carbon monoxide is a promising carbonate-free approach to produce ethylene using renewable electricity. However, the performance of this process suffers from low selectivity and en...
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Exploring the Interplay between Local Chain Structure and Stress Distribution in Polymer Networks
The mechanical behavior of polymer networks is intrinsically correlated with the local chain topology and chain connectivity. In this study, we delve into this relationship through the lens of coarse-grained m...
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Open AccessOsMAPK6 phosphorylation and CLG1 ubiquitylation of GW6a non-additively enhance rice grain size through stabilization of the substrate
The chromatin modifier GRAIN WEIGHT 6a (GW6a) enhances rice grain size and yield. However, little is known about its gene network determining grain size. Here, we report that MITOGEN-ACTIVED PROTEIN KINASE 6 (...
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Preparation of TPPZn/Ag3PO4 Electrospun Fiber Material and Removal of Organic Dyes
Rapid industrialization and ever-growing human activities have caused more and more serious water pollution in the last few decades, posing great threats towards both human health and ecological environment. O...
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Open AccessThe rise of baobab trees in Madagascar
The baobab trees (genus Adansonia) have attracted tremendous attention because of their striking shape and distinctive relationships with fauna1. These spectacular trees have also influenced human culture, inspir...
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Open AccessAnalysis of the influencing factors of the scientific fitness literacy of nurses in the context of exercise and medicine integration
The present study aims to explore the influencing factors of the scientific fitness literacy of nurses and provide a strategic basis for literacy improvement.
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Combined exposure to multiple metals on abdominal aortic calcification: results from the NHANES study
Exposure to metals increases the risk of many diseases and has become a public health concern. However, few studies have focused on the effect of metal on abdominal aortic calcification (AAC), especially the c...
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Open AccessStructural bases of inhibitory mechanism of CaV1.2 channel inhibitors
The voltage-gated calcium channel CaV1.2 is essential for cardiac and vessel smooth muscle contractility and brain function. Accumulating evidence demonstrates that malfunctions of CaV1.2 are involved in brain an...
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Open AccessCorrection: Clinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence
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Temporal dynamics of the microbial heterogeneity–diversity relationship in microcosmic systems
Spatial heterogeneity significantly enhances biodiversity, representing one of the ecology's most enduring paradigms. However, many studies have found decreasing, humped, and neutral correlations between spati...
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Targeting cytohesin-1 suppresses acute myeloid leukemia progression and overcomes resistance to ABT-199
Adhesion molecules play essential roles in the homeostatic regulation and malignant transformation of hematopoietic cells. The dysregulated expression of adhesion molecules in leukemic cells accelerates diseas...
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Open AccessOral pathogens exacerbate Parkinson’s disease by promoting Th1 cell infiltration in mice
Parkinson’s disease (PD) is a common chronic neurological disorder with a high risk of disability and no cure. Periodontitis is an infectious bacterial disease occurring in periodontal supporting tissues. Stud...
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Two annular CsI(Tl) detector arrays for the charged particle telescopes
In this study, we constructed two annular detector arrays comprising 24 wedge-shaped CsI(Tl) crystals, and tested them using an \(\alpha\) ...
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Open AccessDevelopment of a clinical automatic calculation of hypoglycemia during hemodialysis risk in patients with diabetic nephropathy
Hypoglycemia is one of the most common complications in patients with DN during hemodialysis. The purpose of the study is to construct a clinical automatic calculation to predict risk of hypoglycemia during he...
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Dual-loading strategy to construct Au-BiOBr-TiO2 photocatalysts for fast and efficient degradation of xanthates under visible light
With the advancement of mining operations, xanthate as an essential flotation reagent is unavoidably released into natural water bodies through flotation effluent. To protect the surrounding environment of min...
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Open AccessEZH2-mediated epigenetic silencing of tumor-suppressive let-7c/miR-99a cluster by hepatitis B virus X antigen enhances hepatocellular carcinoma progression and metastasis
Hepatitis B virus (HBV)-encoded X antigen, HBx, assists in the development of hepatocellular carcinoma (HCC) through complex mechanisms. Our results provide new insights into the EZH2 epigenetic repression of ...
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Open AccessClinical-mediated discovery of pyroptosis in CD8+ T cell and NK cell reveals melanoma heterogeneity by single-cell and bulk sequence
Histologically, melanoma tissues had fewer positive cells percentage of pyroptosis-related genes (PRGs), GZMA, GSDMB, NLRP1, IL18, and CHMP4A in epidermal than in normal skin. Pyroptosis, a new frontier in can...
