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Open AccessRegular gastroscopy and colonoscopy during the evaluation of urachal cancer: do we really need them?
Urachal cancer is similar to gastrointestinal adenocarcinoma in histology, and gastroscopy/colonoscopy is often administered during perioperative evaluation. However, gastroscopy and colonoscopy have correspon...
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Open AccessSIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence
Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without ef...
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Open AccessCorrection To: Signaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
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Open AccessSignaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
Ischemic stroke is caused primarily by an interruption in cerebral blood flow, which induces severe neural injuries, and is one of the leading causes of death and disability worldwide. Thus, it is of great nec...
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Open AccessBOD1 regulates the cerebellar IV/V lobe-fastigial nucleus circuit associated with motor coordination
Cerebellar ataxias are characterized by a progressive decline in motor coordination, but the specific output circuits and underlying pathological mechanism remain poorly understood. Through cell-type-specific ...
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Open AccessRole of the PPAR pathway in atrial fibrillation associated with heart valve disease: transcriptomics and proteomics in human atrial tissue
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Article
Open AccessAMPKα1 confers survival advantage of colorectal cancer cells under metabolic stress by promoting redox balance through the regulation of glutathione reductase phosphorylation
Patients with stage II or III colorectal cancer (CRC) exhibit various clinical outcomes after radical treatments. The 5-year survival rate was between 50 and 87%. However, the underlying mechanisms of the vari...
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Open AccessEnhanced antitumor and anti-angiogenic effects of metronomic Vinorelbine combined with Endostar on Lewis lung carcinoma
Conventional chemotherapy is commonly used to treat non-small cell lung cancer (NSCLC) however it increases therapeutic resistance. In contrast, metronomic chemotherapy (MET) is based on frequent drug administ...