568 Result(s)
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Article
**ao-Wei Huang
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Open AccessATP6V0A1-dependent cholesterol absorption in colorectal cancer cells triggers immunosuppressive signaling to inactivate memory CD8+ T cells
Obesity shapes anti-tumor immunity through lipid metabolism; however, the mechanisms underlying how colorectal cancer (CRC) cells utilize lipids to suppress anti-tumor immunity remain unclear. Here, we show th...
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Copper-catalyzed enantioselective desymmetrizing C(sp2)–H functionalization of azide-ynamides via α-imino copper carbenes
α-Imino metal carbenes are versatile intermediates in organic synthesis, and have broad applications in the assembly of divergent N-heterocycles. However, the catalytic enantioselective desymmetrization based on
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Coastal citizen science monitoring and suggested conservation strategy: ghost crab survey at Suao Dakenggu, Taiwan
Beaches provide a buffer zone between the sea and the land, which mitigates the impact of natural hazards on waterfront residents. In this study, the beach at the Dakenggu community in Suao Township, Yilan, wa...
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Preparation of three-dimensional nanoporous copper foil with high specific surface area
The porous copper foil material has the advantages of ultra-light and ultra-thin, and can prevent dangers such as thermal runaway and battery fire, which could be regarded as a prospective material for lithium...
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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint: A Retrospective Analysis
To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant chemotherapy.
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Open AccessSensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice
Psoriasis is an immune-mediated skin disease associated with neurogenic inflammation, but the underlying molecular mechanism remains unclear. We demonstrate here that acid-sensing ion channel 3 (ASIC3) exacerb...
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A global survey on the use of the international classification of diseases codes for metabolic dysfunction-associated fatty liver disease
With the implementation of the 11th edition of the International Classification of Diseases (ICD-11) and the publication of the metabolic dysfunction-associated fatty liver disease (MAFLD) nomenclature in 2020...
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Open AccessHigh prevalence of exon-13 variants in USH2A-related retinal dystrophies in Taiwanese population
Biallelic pathogenic variants in USH2A lead to Usher syndrome or non-syndromic retinitis pigmentosa, and shown to have geographical and ethnical distribution in previous studies. This study provided a deeper unde...
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Open AccessA Lactobacillus Combination Ameliorates Lung Inflammation in an Elastase/LPS—induced Mouse Model of Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is the world's leading lung disease and lacks effective and specific clinical strategies. Probiotics are increasingly used to support the improvement of the course ...
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Open AccessExploring plant-derived phytochrome chaperone proteins for light-switchable transcriptional regulation in mammals
Synthetic biology applications require finely tuned gene expression, often mediated by synthetic transcription factors (sTFs) compatible with the human genome and transcriptional regulation mechanisms. While v...
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Gender Difference in Neurodevelopment Disorders Among Late Preterm Infants: Exploring the Impact of Antenatal Corticosteroid Timing
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Environmental Enrichment Improves the Recognition Memory in Adult Mice Following Social Isolation via Downregulation of Kv4.2 Potassium Channels
Recognition memory is a cognitive process that enables us to distinguish familiar objects and situations from new items, which is essential for mammalian survival and adaptation to a changing environment. Soci...
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Fabrication of Tremella-Like Zn-Based Composite Coating with Improved Photocatalytic Degradation Performance and Robust Superhydrophobicity
In this paper, as-received Zn powder and as-prepared Zn@(ZnWO4/ZnO) core–shell powder were used as feedstocks for plasma spraying to prepare Zn-based composite coatings and nano-ZnO was co-deposited by chemical v...
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MOF-Derived Bimetal-Embedded Carbon with Etched Morphologies as an Efficient Activator of Peroxymonosulfate for Eliminate Emerging Contaminants
As bis(4-hydroxyphenyl)methanone (BHP) is one of the most common UV light stabilizers (UVLS), but exhibits endocrine disrupting toxicity, this study aims to develop useful sulfate radical-based techniques to e...
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Open AccessLink Brain-Wide Projectome to Neuronal Dynamics in the Mouse Brain
Knowledge about the neuronal dynamics and the projectome are both essential for understanding how the neuronal network functions in concert. However, it remains challenging to obtain the neural activity and th...
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Open AccessNeoantigen-augmented iPSC cancer vaccine combined with radiotherapy promotes antitumor immunity in poorly immunogenic cancers
Although irradiated induced-pluripotent stem cells (iPSCs) as a prophylactic cancer vaccine elicit an antitumor immune response, the therapeutic efficacy of iPSC-based cancer vaccines is not promising due to t...
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Human amniotic epithelial stem cell is a cell therapy candidate for preventing acute graft-versus-host disease
Graft-versus-host disease (GVHD), an immunological disorder that arises from donor T cell activation through recognition of host alloantigens, is the major limitation in the application of allogeneic hematopoi...
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Open AccessPhosphorus deficiency alleviates iron limitation in Synechocystis cyanobacteria through direct PhoB-mediated gene regulation
Iron and phosphorus are essential nutrients that exist at low concentrations in surface waters and may be co-limiting resources for phytoplankton growth. Here, we show that phosphorus deficiency increases the ...
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Molecular Cloning and Functional Analysis of ScHAK10 Gene Promoter from Sugarcane (Saccharum officinarum L.)
Transcriptional regulation of the high-affinity K+ (HAK) transporter gene is an important mechanism of plant response to low potassium stress. Cloning and analysis of the promoter of potassium transporter gene is...
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Open AccessStructural basis and synergism of ATP and Na+ activation in bacterial K+ uptake system KtrAB
The K+ uptake system KtrAB is essential for bacterial survival in low K+ environments. The activity of KtrAB is regulated by nucleotides and Na+. Previous studies proposed a putative gating mechanism of KtrB regu...
