30 Result(s)
within
Article
**an-Hua Guan
Life Sciences
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Article
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities
Molecular profiling guides precision treatment of breast cancer; however, Asian patients are underrepresented in publicly available large-scale studies. We established a comprehensive multiomics cohort of 773 ...
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Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN–pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RI...
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Genetic variations in the bitter taste receptor gene TAS2R38 are related to cigarette smoking behavior in Han Chinese smokers
Smoking behavior is influenced by multiple genes, including the bitter taste gene TAS2R38. It has been reported that the correlation between TAS2R38 and smoking behavior has ethnicity-based differences. However, ...
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A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and organ fibrosis
Innate DNA sensing via the cyclic GMP-AMP synthase–stimulator of interferon genes (cGAS–STING) mechanism surveys microbial invasion and cellular damage and thus participates in various human infectious disease...
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Combined System of Organic Substrate and Straw-Degrading Microbial Agents Improved Soil Organic Matter Levels and Microbial Abundance in a Rice–Wheat Rotation
Rice–wheat rotation is one of the most intensive agricultural planting modes in China and is pivotal to develop optimized straw-returning management in situ to improve soil fertility and productivity in agricu...
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Open AccessSARS-CoV-2 uses metabotropic glutamate receptor subtype 2 as an internalization factor to infect cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) uses angiotensin-converting enzyme 2 (ACE2) as a binding receptor to enter cells via clathrin-mediated endocytosis (CME). However, receptors involve...
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Open AccessComparative transcriptome analysis of coleorhiza development in japonica and Indica rice
Coleorhiza hairs, are sheath-like outgrowth organs in the seeds of Poaceae family that look like root hair but develop from the coleorhiza epidermal cells during seed imbibition. The major role of coleorhiza hair...
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Open AccessSingle-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor microenvironment (TME) represents a ...
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Open AccessPurity and Uncertainty Study of CRM Betulin by DSC
Betulin (BE) can be obtained from many plants, such as those belonging Betulaceae family, and pharmacological investigations showed its notable biological properties and good potential for food and pharmaceuti...
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Open AccessAnalysis of Four Solvatomorphs of Betulin by TG–DTA–EI/PI–MS System Equipped with the Skimmer-Type Interface
Betulin (BE) has exceedingly become a potential natural product, providing multiple pharmacological and biological activities, including anti-cancer, anti-viral, and anti-inflammatory benefits. Previous research ...
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Open AccessThe hornwort genome and early land plant evolution
Hornworts, liverworts and mosses are three early diverging clades of land plants, and together comprise the bryophytes. Here, we report the draft genome sequence of the hornwort Anthoceros angustus. Phylogenomic ...
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Bioinformatic prediction of critical genes and pathways involved in longevity in Drosophila melanogaster
The pursuit of longevity has been the goal of humanity since ancient times. Genetic alterations have been demonstrated to affect lifespan. As increasing numbers of pro-longevity genes and anti-longevity genes ...
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Inheritance patterns of anthocyanins in berry skin and flesh of the interspecific population derived from teinturier grape
Successful cross-breeding requires the investigation into the inheritance pattern of desirable traits. The present study recorded the segregation in coloration and analyzed anthocyanin concentration and compos...
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Overexpression of gene encoding the key enzyme involved in proline-biosynthesis (PuP5CS) to improve salt tolerance in switchgrass (Panicum virgatum L.)
Genetic improvement through overexpressing PuP5CS in switchgrass is feasible for enhancing plant salt stress tolerance.
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Integrated genomic and transcriptomic insights into the two-component high-affinity nitrate transporters in allotetraploid rapeseed
The two-component high-affinity nitrate (NO3-) transport system (THATS) proteins (NRT2/NAR2) play key roles in the efficient nitrogen (N) uptake and transport under N limitations. We aimed at uncovering the core ...
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The extracellular domain of Staphylococcus aureus LtaS binds insulin and induces insulin resistance during infection
Insulin resistance is a risk factor for obesity and diabetes and predisposes individuals to Staphylococcus aureus colonization; however, the contribution of S. aureus to insulin resistance remains unclear. Here, ...
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The complete chloroplast genome of a vulnerable species Champereia manillana (Opiliaceae)
Champereia manillana (Bl.) Merr. is a vulnerable plant from the family Opiliaceae. The complete chloroplast genome (plastome) of Opiliaceae family was sequenced for the first time. The pl...
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Open AccessDrought-responsive WRKY transcription factor genes TaWRKY1 and TaWRKY33 from wheat confer drought and/or heat resistance in Arabidopsis
Drought stress is one of the major causes of crop loss. WRKY transcription factors, as one of the largest transcription factor families, play important roles in regulation of many plant processes, including dr...
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Open AccessComplete genome sequence and genomic characterization of Microcystis panniformis FACHB 1757 by third-generation sequencing
The cyanobacterial genus Microcystis is well known as the main group that forms harmful blooms in water. A strain of Microcystis, M. panniformis FACHB1757, was isolated from Meiliang Bay of Lake Taihu in August 2...
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Anthocyanin biosynthesis is differentially regulated by light in the skin and flesh of white-fleshed and teinturier grape berries
Light exclusion reduces the concentration and modifies the composition of grape anthocyanins, by altering the expression of genes involved in anthocyanin biosynthesis and transport, in a cultiv...
