1,099 Result(s)
within
Life Sciences
**-Peng Li
Article
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Article
Open AccessRecent advances in the pathogenesis and prevention strategies of dental calculus
Dental calculus severely affects the oral health of humans and animal pets. Calculus deposition affects the gingival appearance and causes inflammation. Failure to remove dental calculus from the dentition res...
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Open AccessSynthetic macrolides overcoming MLSBK-resistant pathogens
Conventional macrolide-lincosamide-streptogramin B-ketolide (MLSBK) antibiotics are unable to counter the growing challenge of antibiotic resistance that is conferred by the constitutive methylation of rRNA base ...
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Open AccessZero-shot prediction of mutation effects with multimodal deep representation learning guides protein engineering
Mutations in amino acid sequences can provoke changes in protein function. Accurate and unsupervised prediction of mutation effects is critical in biotechnology and biomedicine, but remains a fundamental chall...
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Open AccessA novel LGALS1-depended and immune-associated fatty acid metabolism risk model in acute myeloid leukemia stem cells
Leukemia stem cells (LSCs) are recognized as the root cause of leukemia initiation, relapse, and drug resistance. Lipid species are highly abundant and essential component of human cells, which often changed i...
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Open AccessPhase separation of RNF214 promotes the progression of hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...
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Open AccessDeep migration learning-based recognition of diseases and insect pests in Yunnan tea under complex environments
The occurrence, development, and outbreak of tea diseases and pests pose a significant challenge to the quality and yield of tea, necessitating prompt identification and control measures. Given the vast array ...
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Open AccessSystematic comparison of sequencing-based spatial transcriptomic methods
Recent developments of sequencing-based spatial transcriptomics (sST) have catalyzed important advancements by facilitating transcriptome-scale spatial gene expression measurement. Despite this progress, effor...
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Analysis of Root Response Mechanism of Quinoa Seedlings to Waterlogging Stress Based on Metabolome
Quinoa, a dicotyledonous annual herb belonging to the subfamily Amaranthaceae, has remarkable resistance to cold, drought, and barren conditions. However, few studies have reported on quinoa root metabolism un...
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Genome-wide association studies dissect low-phosphorus stress response genes underling field and seedling traits in maize
Phosphorus (P) is an essential element for plant growth, and its deficiency can cause decreased crop yield. This study systematically evaluated the low-phosphate (Pi) response traits in a large population at m...
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The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs) have been associated with potential cardiovascular benefits, partly attributed to their bioactive metabolites. However, the underlying mechanisms responsible for...
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Nuclear translocation of β-catenin and migration of arecoline-induced oral cancer cells reduced by Taiwanin E via p-GSK3β downregulation
Oral squamous cell carcinomas (OSCCs) accounts for 90% of the total oral cancers and is a major public health issue worldwide. It is the most prevalent malignant epithelial neoplasm of the oral cavity.
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Open AccessSusceptibility gene identification and risk evaluation model construction by transcriptome-wide association analysis for salt sensitivity of blood pressure
Salt sensitivity of blood pressure (SSBP) is an intermediate phenotype of hypertension and is a predictor of long-term cardiovascular events and death. However, the genetic structures of SSBP are uncertain, an...
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Open AccessLipidomic signatures in patients with early-onset and late-onset Preeclampsia
Preeclampsia is a pregnancy-specific clinical syndrome and can be subdivided into early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE) according to the gestational age of delivery. Patients with ...
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Development of Sugar Industry in China: R&D Priorities for Sustainable Sugarcane Production
This paper introduces the status of the sugar industry in China, especially the production of sugarcane, sugarbeet and sugar, as well as achievements in sugarcane breeding, farming technology exploitation and ...
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Exploring the phosphorus–starch content balance mechanisms in maize grains using GWAS population and transcriptome data
Examining the connection between P and starch-related signals can help elucidate the balance between nutrients and yield. This study utilized 307 diverse maize inbred lines to conduct multi-year and multi-plot...
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Open AccessIntegrated transcriptomic and metabolomic analysis provides insight into the pollen development of CMS-D1 rice
Cytoplasmic male sterility (CMS) has greatly improved the utilization of heterosis in crops due to the absence of functional male gametophyte. The newly developed sporophytic D1 type CMS (CMS-D1) rice exhibits...
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Electron Beam Irradiation Inhibited Potato Sprouting by Regulating the Metabolism of Membrane Lipid Peroxidation and Antioxidant
This study evaluated the effects of high-energy electron beams (e-beams) on sprouting, physical–chemical properties and membrane lipid peroxidation of ‘Zihuabai’ potatoes stored at 8 ± 1 ℃. Sprouting of all ir...
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Open AccessMechanisms and clinical landscape of N6-methyladenosine (m6A) RNA modification in gastrointestinal tract cancers
Epigenetics encompasses reversible and heritable chemical modifications of non-nuclear DNA sequences, including DNA and RNA methylation, histone modifications, non-coding RNA modifications, and chromatin rearr...
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Open AccessTREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice
The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and counteracting inflamm...
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Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders
Metabolically healthy obesity refers to obese individuals who do not develop metabolic disorders. These people store fat in subcutaneous adipose tissue (SAT) rather than in visceral adipose tissue (VAT). Howev...
