164 Result(s)
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Article
** Tae Kim
Oncology
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Hepatic resections for primary liver cancer
The medical records of 399 patients who underwent hepatic resection between January 1981 and December 1990 were reviewed. Information regarding the results of the hepatic resection in terms of the operative in...
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The effect of pyrimidine nucleosides on adenosine-induced apoptosis in HL-60 cells
Among several nucleosides, adenosine is the only one to induce typical apoptotic cell death in human promyelocytic leukemia HL-60 cells. Intracellularly transported adenosine seemed to be required for the ind...
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Epidemiological Study on Korean Gallstone Disease (A Nationwide Cooperative Study)
To clarify the epidemiological characteristicsof gallstone disease in Korea and to evaluate thechronological changes in gallstone disease, the authorsperformed this first prospective nationwide cooperative stu...
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Brain Tumor Imaging with 99mTc-tetrofosmin: Comparison with 201Tl, 99mTc-MIBI, and 18F-fluorodeoxyglucose
The purpose of the present study was to assess the ability of technetium-99m-tetrofosmin (99mTc-TF) to predict tumor malignancy and to compare its uptake with that of thallium-201 (201Tl), technetium-99m-hexakis-...
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Inhibition of AP-1 transcription factor causes blockade of multiple signal transduction pathways and inhibits breast cancer growth
AP-1 transcription factors play a critical role in signal transduction pathways in many cells. We have investigated the role of AP-1 in controlling proliferative signals in breast cells, and have previously sh...
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Extratemporal hypometabolism on FDG PET in temporal lobe epilepsy as a predictor of seizure outcome after temporal lobectomy
We investigated the relationship between the presence of extratemporal hypometabolism on fluorine-18 fluorodeoxyglucose positron emission tomography (FDG PET) and seizure outcome after temporal lobectomy in pa...
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BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest
The tumor suppressor protein BRCA1 has been shown to enhance p53 transcription, whereas activated p53 represses BRCA1 transcription. To further understand the functional interaction of these proteins, we inves...
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Specific endothelial binding and tumor uptake of radiolabeled angiostatin
Angiostatin (AS) is a potent antiangiogenic agent which inhibits tumor growth through specific action on proliferating endothelial cells. Imaging of radiolabeled AS would enhance our knowledge on the pharmacok...
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Loss of the Smad3 expression increases susceptibility to tumorigenicity in human gastric cancer
Loss of the tumor suppressive effect of transforming growth factor-β (TGF-β) has been commonly found at later stages in carcinogenic progression. Although the genes encoding TGF-β receptors and Smads have been fo...
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Targeting of lacZ reporter gene expression with radioiodine-labelled phenylethyl-β-d-thiogalactopyranoside
There has recently been increasing interest in the development of radioprobes that specifically target proteins transcribed from expression of reporter genes of interest. The purpose of this study was to devel...
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The negative role of cyclin G in ATM-dependent p53 activation
Cyclin G is one of the earliest p53 target genes to be identified, but its function in the p53 pathway has been elusive. Although the precise mechanisms of cyclin G in this novel network have not been explored...
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Gemcitabine monotherapy as salvage chemotherapy in heavily pretreated metastatic breast cancer
We evaluated the efficacy and tolerability of gemcitabine monotherapy in heavily pretreated, breast cancer patients as salvage chemotherapy.
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Mutation Analysis of SPINK1 and CFTR Gene in Korean Patients with Alcoholic Chronic Pancreatitis
Several genetic mutations have been reported to increase susceptibility to chronic pancreatitis. However, their roles in alcoholic chronic pancreatitis are controversial. We investigated the prevalence of SPINK1 ...
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Perfusion abnormality of the caudate nucleus in patients with paroxysmal kinesigenic choreoathetosis
Previous cerebral blood flow and glucose metabolism studies suggest that the basal ganglia or thalamus is involved in the pathogenesis of paroxysmal kinesigenic choreoathetosis (PKC). However, the underlying c...
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Neonatal hypoglycaemic encephalopathy: diffusion-weighted imaging and proton MR spectroscopy
We report two infants with neonatal hypoglycaemic encephalopathy who were evaluated with diffusion-weighted imaging (DWI) and proton MR spectroscopy (MRS) as well as conventional MR. As in conventional MR, DWI...
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Prognostic Significance of Vascular Endothelial Growth Factor Expression and Microvessel Density in Esophageal Squamous Cell Carcinoma: Comparison With Positron Emission Tomography
This study investigated whether the expression of vascular endothelial growth factor (VEGF) in a primary tumor and the intratumoral microvessel density (MVD) were independent prognostic factors in patients wit...
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Outcomes of Cystic Lesions in the Pancreas After Extended Follow-up
Incidental pancreatic cysts are frequently detected, but no appropriate management guidelines have been issued for their management because their natural history is relatively unknown. The aim of this study wa...
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Recurrence and Prognostic Factors of Ampullary Carcinoma after Radical Resection: Comparison with Distal Extrahepatic Cholangiocarcinoma
Ampullary carcinoma is often considered to have a better prognosis than distal extrahepatic cholangiocarcinoma. However, studies that directly compare the recurrence and histopathological features between the ...
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A phase II trial of modified weekly irinotecan and cisplatin for chemotherapy-naïve patients with metastatic or recurrent squamous cell carcinoma of the esophagus
This phase II study assessed the efficacy and toxicity profile of a modified weekly irinotecan and cisplatin for chemotherapy-naïve patients with metastatic/recurrent esophageal squamous cell carcinoma (SQCC).
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Effects of anesthetic agents on cellular 123I-MIBG transport and in vivo 123I-MIBG biodistribution
Small animal imaging with meta-iodobenzylguanidine (MIBG) allows characterization of animal models, optimization of tumor treatment strategies, and monitoring of gene expression. Anesthetic agents, however, ca...
