41 Result(s)

Article

ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP

Mutations resulting in decreased activity of p53 tumor suppressor protein promote tumorigenesis. P53 protein levels are tightly regulated through the Ubiquitin Proteasome System (UPS). Several E3 ligases were ...

Ruqaia Abbas, Oliver Hartmann, Dorin Theodora Asiss, Rabab Abbas, Julia Kagan… in Apoptosis (2024)

Article

Correction: Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial

Jung Hyun Jo, Yong-Tae Kim, Ho Soon Choi, Ho Gak Kim… in British Journal of Cancer (2024)

Article

Efficacy of GV1001 with gemcitabine/capecitabine in previously untreated patients with advanced pancreatic ductal adenocarcinoma having high serum eotaxin levels (KG4/2015): an open-label, randomised, Phase 3 trial

The TeloVac study indicated GV1001 did not improve the survival of advanced pancreatic ductal adenocarcinoma (PDAC). However, the cytokine examinations suggested that high serum eotaxin levels may predict resp...

Jung Hyun Jo, Yong-Tae Kim, Ho Soon Choi, Ho Gak Kim… in British Journal of Cancer (2024)

Article

Genomic and evolutionary characteristics of metastatic gastric cancer by routes

In gastric cancer (GC) patients, metastatic progression through the lymphatic, hematogenous, peritoneal, and ovarian routes, is the ultimate cause of death. However, the genomic and evolutionary characteristic...

Jae Eun Lee, Ki Tae Kim, Su-** Shin, Jae-Ho Cheong… in British Journal of Cancer (2023)

Article

^99mTc-MAA accumulation within tumor in preoperative lung perfusion SPECT/CT associated with occult lymph node metastasis in patients with clinically N0 non-small cell lung cancer

^99mTc-MAA accumulation within the tumor representing pulmonary arterial perfusion, which is variable and may have a clinical significance. We evaluated the prognostic significance of ^99mTc-MAA distribution within...

Vanessa Murad, Minseok Suh, Hongyoon Choi, Gi Jeong Cheon, Kwon Joong Na… in BMC Cancer (2023)

Article

High tumor hexokinase-2 expression promotes a pro-tumorigenic immune microenvironment by modulating CD8+/regulatory T-cell infiltration

Relationship between cancer cell glycolysis and the landscape of tumor immune microenvironment in human cancers was investigated.

Sehui Kim, Jaemoon Koh, Seung Geun Song, Jeemin Yim, Miso Kim, Bhumsuk Keam… in BMC Cancer (2022)

Article

Improving anticancer effect of aPD-L1 through lowering neutrophil infiltration by PLAG in tumor implanted with MB49 mouse urothelial carcinoma

The PD-L1 antibody is an immune checkpoint inhibitor (ICI) attracting attention. The third-generation anticancer drug has been proven to be very effective due to fewer side effects and higher tumor-specific re...

Guen Tae Kim, Eun Young Kim, Su-Hyun Shin, Hyowon Lee, Se Hee Lee… in BMC Cancer (2022)

Article

Comparison between FOLFIRINOX and gemcitabine plus nab-paclitaxel including sequential treatment for metastatic pancreatic cancer: a propensity score matching approach

FOLFIRINOX (FFX) and Gemcitabine plus nab-paclitaxel (GnP) have been recommended as the first-line chemotherapy for metastatic pancreatic cancer (mPC). However, the evidence is lacking comparing not only two r...

Jung Won Chun, Sang Hyub Lee, Joo Seong Kim, Namyoung Park, Gunn Huh… in BMC Cancer (2021)

Article

A randomised phase 2b study comparing the efficacy and safety of belotecan vs. topotecan as monotherapy for sensitive-relapsed small-cell lung cancer

This study compared the efficacy/safety of the camptothecin analogues belotecan and topotecan for sensitive-relapsed small-cell lung cancer (SCLC).

**-Hyoung Kang, Ki-Hyeong Lee, Dong-Wan Kim, Sang-We Kim… in British Journal of Cancer (2021)

Article

A multicentre, randomised, open-label, parallel-group Phase 2b study of belotecan versus topotecan for recurrent ovarian cancer

This Phase 2b study compared the efficacy and toxicity of belotecan and topotecan in recurrent ovarian cancer.

Hee Seung Kim, Sang-Yoon Park, Chan-Yong Park, Young Tae Kim… in British Journal of Cancer (2021)

Article

High platelet-to-lymphocyte ratio is associated with poor prognosis in patients with unresectable intrahepatic cholangiocarcinoma receiving gemcitabine plus cisplatin

Several systemic inflammatory response (SIR) markers, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and albumin-to-globulin ratio (AGR)...

Gunn Huh, Ji Kon Ryu, Jung Won Chun, Joo Seong Kim, Namyoung Park, In Rae Cho… in BMC Cancer (2020)

Article

Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer

Poly (ADP-ribose) polymerase inhibitors targeting BRCA1/2 mutations are available for treating patients with high-grade serous ovarian cancer. These treatments may be more appropriately directed to patients who m...

Kyung ** Eoh, Hye Min Kim, Jung-Yun Lee, Sunghoon Kim, Sang Wun Kim… in BMC Cancer (2020)

Article

Germline BRCA, chemotherapy response scores, and survival in the neoadjuvant treatment of ovarian cancer

To analyze the effects of BRCA1/2 mutations on chemotherapy response scores (CRS) and survival in a cohort of patients with advanced-stage ovarian cancer who were treated with neoadjuvant chemotherapy (NAC) follo...

Yong Jae Lee, Hyun-Soo Kim, John Hoon Rim, Jung-Yun Lee, Eun Ji Nam… in BMC Cancer (2020)

Article

The institutional learning curve is associated with survival outcomes of robotic radical hysterectomy for early-stage cervical cancer-a retrospective study

Despite recent advances in diagnosis and treatment, cervical cancer continues to be a significant health problem worldwide. Whereas robot-assisted surgery has advantages over the abdominal approach, and minima...

Kyung ** Eoh, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim… in BMC Cancer (2020)

Article

Lymph node ratio as valuable predictor in pancreatic cancer treated with R0 resection and adjuvant treatment

Lymph-node (LN) metastasis is an important prognostic factor in resected pancreatic cancer. In this study, the prognostic value of American Joint Committee on Cancer (AJCC) 8th edition N stage, lymph-node rati...

Min Su You, Sang Hyub Lee, Young Hoon Choi, Bang-sup Shin, Woo Hyun Paik… in BMC Cancer (2019)

Article

Comprehensive molecular and clinical characterization of Asian melanoma patients treated with anti-PD-1 antibody

Clinical features of Asian melanoma patients are distinct from those of Western patients. This study was designed to determine the molecular and clinical characteristics of Asian melanoma patients treated with...

Jiyun Lee, Su ** Lee, Kyung Kim, Seung Tae Kim, Kee-Taek Jang, Jeeyun Lee in BMC Cancer (2019)

Article

Therapeutic outcomes and prognostic factors in unresectable gallbladder cancer treated with gemcitabine plus cisplatin

Gallbladder cancer (GBC) is likely to be diagnosed at progressive stages and shows a very poor prognosis. Combination therapy with gemcitabine and cisplatin (GEMCIS) has been widely used as first-line palliati...

Min su You, Ji Kon Ryu, Young Hoon Choi, ** Ho Choi, Gunn Huh, Woo Hyun Paik… in BMC Cancer (2019)

Article

Prognostic significance of supradiaphragmatic lymph node metastasis detected by ¹⁸F-FDG PET/CT in advanced epithelial ovarian cancer

Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed t...

In Ok Lee, Jung-Yun Lee, Hyun Jeong Kim, Eun Ji Nam, Sunghoon Kim… in BMC Cancer (2018)

Article

Triptolide as a novel agent in pancreatic cancer: the validation using patient derived pancreatic tumor cell line

Triptolide induces apoptosis and DNA damage followed by inhibition of DNA repair associated gene expression. However, there is the limited data for biomarker to predict the benefit to triptolide in various can...

Seung Tae Kim, Sun Young Kim, Jeeyun Lee, Kyung Kim, Se Hoon Park… in BMC Cancer (2018)

Article

Prediction of perioperative complications after robotic-assisted radical hysterectomy for cervical cancer using the modified surgical Apgar score

Although there has been marked development in surgical techniques, there is no easy and fast method of predicting complications in minimally invasive surgeries. We evaluated whether the modified surgical Apgar...

Seon Hee Park, Jung-Yun Lee, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim… in BMC Cancer (2018)