1,124 Result(s)
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Article
L-Tryptophane and sleep
L-Tryptophane, an essential amino acid and a precursor of serotonin, is shown to have definite effects on human sleep. In normal subjects it reduces sleep latency and slightly increases sleep length without alt....
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Doxepin and amitriptyline-perphenazine in mixed anxious-depressed neurotic outpatients: A collaborative controlled study
Doxepin was compared to the combination of amitriptyline-perphenazine in a double-blind controlled study conducted with 100 clinic, general practice, and private psychiatric practice outpatients diagnosed as s...
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Article
Clomipramine and amitriptyline in depressed outpatients
Clomipramine (75–125 mg/day), a relatively new tricyclic anti-depressant, was compared to amitriptyline (75–125 mg/day) in a double-blind 6 week trial carried out with 93 psychiatric and 75 non-psychiatric dep...
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Strategies for the synthesis of kallikrein substrates useful for radioassay
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Drug-Induced Cardiovascular Diseases
A wide variety of drugs may be associated with serious cardiovascular toxicity. Toxicity due to drugs primarily used for treating cardiac disorders is the most extensively documented, especially the arrhythmia...
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Studies on the constituents of the higher fungi of Korea(XI)
From the carpophores ofCoriolus sanguineus Fr., a bright-red, wood-rotting fungus, which were collected at Suwon, an antibiotic component was isolated as red crystal and identified as cinnabarin by UV and IR spec...
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A survey of the response of Korean medicinal plants on drug metabolism
Alcohol extracts of plants widely used in the traditional medicine have been tested to establish if they affect the metabolism of drugs in mice.
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Article
Sedative action of spinosin
The acute toxicity and the sedative action of spinosin isolated fromZizyphus seeds have been tested with mice.
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Article
The effects of mushroom components on the proliferation of HeLa cell linein vitro
In order to find out nutritional effects of Korean edible mushrooms on the multiplication of tissue cells, the alcohol extracts and acid hydrolysates of eleven species of mushrooms were added to Earle’s BSS. A...
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The crystal and molecular structure of sulfapyridine
The crystal structure of sulfapyridine, C11 H11N3O2S, has been determined by X-ray diffraction method. The compound crystallizes in the monoclinic space group C2/c with a=12.80(4), b=11.72(4), c=15.36(5)Å, β=94(3...
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Article
Isolation, purification and characterization of phytohemagglutinating proteins from Korean natural products
Seeds or beans of 55 plants belonging to 31 families were screened by using several different types of red blood cells to find new lectins. In this paper, white kidney bean (Phaseolus vulgaris C.) was chosen to s...
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Article
The crystal and molecular structure of chlorpropamide
Chlorpropamide, C10H13N2O3SCl, forms orthorhombic crystals of space group P212121 with a 9.066±0.004, b=5.218±0.003, c=26. 604±0.008 Å, and four molecules per cell. Three dimensional photographic data were collec...
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Article
Interaction of flavins and some alcohols on the molecular level
The effect of some alcohols on the riboflavin derivatives in non-polar solvent was studied by various spectroscopic method in order to support the viewpoint that alcohol may directly interact with the isoallox...
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Article
Effect of six Chinese drugs on serum transaminase activity and liver tissue in mice
The methanol extracts ofPatriniae radix,Dianthii herba,Melandrii herba,Echinopii radix,Siegesbeckiae herba andMagnoliae cortex showed a significant elevation of serum transaminase activity accompanied by fatty de...
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Article
3-Bromo-5,5-dimethylhydantoin induced ring closure(I)
Reaction of unsaturated acids with 3-bromo-5,5-dimethylhydantoin in dry DMF at room temperature gives bromolactones in 58–91% yields.
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Pharmacokinetic study of sisomicin in humans
Detailed analyses of the pharmacokinetics of sisomicin administered at doses of 25, 50, and 100 mg intravenously and intramuscularly to healthy volunteers established that the drug is handled by a two-compartm.....
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A Clinical Trial with Cefoperazone in Pneumonia and Pyelonephritis
15 cases of pneumonia and 15 cases of pyelonephritis were included in a clinical trial of parenteral cefoperazone. The organisms isolated from patients with bacterial pneumonia were: Staphylococcus aureus (6), Kl...
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Article
Studies on the constituents of higher fungi of Korea
To develop new potent antitumor substances with low toxicity from natural products, especially from higher fungi of Korea, the carpophores of some wild basidiomycetes were collected and the antitumor test for ...
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Article
Studies on the constituents and culture of Korean basidiomycetes
To develop potent antitumor polysaccharides from higher fungi of Korea the alcohol precipitated polysaccharides, which were obtained from hot water extracts of shake-cultured mycelia of eight species of basidi...
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Article
A novel bromolactonization reaction using racemic 3-bromo-5-isobutyl-5-methylhydantoin
By using racemic 3-bromo-5-isobutyl-5-methylhydantoin (3a′) in dry N, N-dimethylformanide which is a model reagent for asymmetric bromolactonization, bromolactonization of a series of olefinic acids was carried o...
