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Basic Constitutive Relations for Unsaturated Media
The following sections describe how to find the hydraulic conductivity, air permeability, electrical conductivity, as well as solute and gas...
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Organolithium in Asymmetric Processes
The development of asymmetric processes has been the focus of industrial research as most of the molecules of pharmaceutical interest contain chiral...
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Rhodium/Ruthenium Applications
Asymmetric catalytic hydrogenation and hydrogen transfer reactions of various substrates such as prochiral ketones and olefins using Rh(I) and Ru(II)...
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Stress Induced by Recombinant Protein Production in Escherichia coli
Strong production of recombinant proteins interferes with cellular processes in many ways. Drainage of precursors and energy urges the cell to...
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Roles of Heat-Shock Chaperones in the Production of Recombinant Proteins in Escherichia coli
Escherichia coli is a versatile organism for the production of recombinant proteins. Often, however, the recombinant protein does not reach its...
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Palladium-Catalyzed Cross-Coupling Reactions in the Synthesis of Pharmaceuticals
The use of Pd-catalyzed cross-coupling methods for the construction of C-C, C-N, and C-O bonds have increased exponentially over the years. The...
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Applications of Organotitanium Reagents
Organometallic transformations involving titanium are employed both catalytically and stoichiometrically in the pharmaceutical and fine chemical...
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Construction of Carbocycles via Zirconacycles and Titanacycles
Metal-mediated selective construction of useful carbocyclic compounds from multi-component reaction systems has attracted much attention in recent...
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Inclusion Bodies: Formation and Utilisation
The efficient in vivo folding of many heterologous proteins is a major bottleneck of high level production in bacterial hosts and simple optimisation...
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Monitoring of Stress Responses
New developments in the RNA analysis techniques now enable a comprehensive view on the bacterial physiology under bioprocess conditions. The DNA-chip...
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Analysis and Control of Proteolysis of Recombinant Proteins in Escherichia coli
Proteolysis is one of the reasons for poor production of recombinant proteins in Escherichia coli. Important properties of E. coli proteases, which...
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Novel Genes Involved in Cephalosporin Biosynthesis: The Three-component Isopenicillin N Epimerase System
Cephalosporin is one of the best β-lactam antibiotics, widely used in the treatment of infectious diseases. It is synthesized by Acremonium...
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Palladium-Catalyzed Heck Arylations in the Synthesis of Active Pharmaceutical Ingredients
The utility of inter- and intramolecular Heck arylations in the synthesis of intermediates for the preparation of active pharmaceutical ingredients...
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The Application of Multi-Parameter Flow Cytometry to Monitor Individual Microbial Cell Physiological State
The development of multi-parameter flow cytometric techniques in our laboratories has led to a functional classification of the physiological state...
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Development of Transition Metal-Mediated Cyclopropanation Reactions
A brief discussion of the methods for cyclopropane formation emphasizing organometallic reagents and catalysts is followed by several examples of the...
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Metallocene-Catalyzed Selective Reactions
Transition metal cyclopentadienyl complexes constitute a large family of compounds that can be used as catalyst for a number of organic...
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Regulation of Cephalosporin Biosynthesis
The filamentous fungus Acremonium chrysogenum is the natural producer of the β-lactam antibiotic cephalosporin C and is as such used worldwide in...