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Biosimilars: Principles, Regulatory Framework, and Societal Aspects
A “generic” version of a biopharmaceutical may be introduced after patents and other exclusivity rights expire. However, the generic paradigm as it... -
Insulin
Insulin was discovered by Banting and Best in 1921. Soon afterwards, manufacturing processes were developed to extract the insulin from porcine and... -
Pharmacokinetics and Pharmacodynamics of Therapeutic Proteins and Nucleic Acids
The rational use of drugs and the design of effective dosage regimens are facilitated by the appreciation of the central paradigm of clinical... -
Antibody-Based Biotherapeutics in Inflammatory Diseases
Inflammatory diseases encompass a broad and diverse spectrum of serious chronic disorders, many of which have significant need for safe and effective... -
Molecular Biotechnology: From DNA Sequence to Therapeutic Protein
Therapeutic proteins have become a valuable addition to the repertoire of drugs to treat patients with severe diseases. Therapeutic proteins differ... -
Antibody-Based Biotherapeutics in Migraine
Migraine is a common, chronic, primary headache disorder characterized by attacks of headache and accompanying symptoms, with a significant personal... -
Advanced Therapy Medicinal Products: Clinical, Non-clinical, and Quality Considerations
Cell therapy, tissue engineering, and gene therapy products, together called “advanced therapy medicinal products” (ATMPs), represent a heterogeneous... -
Hematopoietic Growth Factors
Hematopoiesis is an intricate, well-regulated, and homeostatic multistep process that allows immature precursor cells in the bone marrow to... -
Clinical Applications of 3D Printed Drug Products
Common challenges in pharmaceutical formulation development and clinical manufacturing include manual labor and a lack of flexibility to formulate a... -
Forging a Personalised Path: 3D Printing’s Role in Healthcare Transformation
The voyage towards revolutionising healthcare through digital technologies has launched, and its trajectory promises to reshape the contours of... -
The Significance of Biomaterials in Stem Cell-Based Regenerative Medicine
Introduction: Stem cell-based therapeutic strategies have shown tremendous potential in attenuating tissue damage and facilitating tissue repair and... -
Neurotrophic Factors in Parkinson’s Disease: Clinical Trials
Introduction: Parkinson’s disease (PD)Parkinson’s disease is characterized by the progressive loss of midbrain dopamine (DA) neurons that regulate... -
In Vitro and In Silico ADME Prediction
Pharmacokinetic issues have been identified as a major cause for the attrition of new chemical entities in drug discovery. High development costs and... -
Blood Flow Distribution and Membrane Transporters as Determinant Factors of Tissue Drug Concentration
The free drug hypothesis states that the non-ionized free drug concentrations will have the same value in all the aqueous spaces of the body, once... -
Initiating and Facilitating Brain Repair: Factors, Principles, and Mechanisms
Introduction: Acute injuries to the brain result in a wide range of sequelae, and several factors contribute to the severity of a brain lesion,... -
Challenges and Future Perspectives of Using Bioactive Scaffolds in Brain Repair
Introduction: Scientific and technological developments have allowed the transfer of knowledge to the translational vision of materials, under an... -
Introduction: Biopharmaceutics and Pharmacokinetics
Biopharmaceutics and Pharmacokinetics are pharmaceutical disciplines that are useful for improving the outcome of drug therapies, assisting drug... -
How Sensor Data Can Guide Females Through Training and Recovery According to Their Menstrual Cycle
Besides anatomical and physiological differences between women and men, the hormonal fluctuations in the course of the female menstrual cycle... -
Ring Chromosome 13
Ring chromosome 13 (RC13) is detected using karyoty**, fluorescence in situ hybridization (FISH), and chromosome microarray analysis (CMA) to... -
Diagnostic Methods for Ring Chromosomes
The molecular characterization of ring chromosome (RC) structural aberrations requires the use of cytogenomic techniques. The first RCs were...