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Assessing the occurrence of annual maximum daily discharge for five of the longest rivers in Africa
Widespread flooding in Africa has devastating repercussions on communities, and sometimes leading to loss of life, displacement of populations, and...
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Effectiveness of e-cigarettes as a stop smoking intervention in adults: a systematic review
BackgroundThis systematic review aims to identify the benefits and harms of electronic cigarettes (e-cigarettes) as a smoking cessation aid in adults...
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The Hel** Hand in Ukraine: feasibility and potential impact
BackgroundNew services are needed to prevent the mental health consequences of the war in Ukraine. Ten adolescents self-recruited to use and evaluate...
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Dynamic factor models for claim reserving
This study presents a new approach to claim reserving in the insurance industry using dynamic factor models (DFMs). Traditional methods often...
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MetaV: A Pioneer in feature Augmented Meta-Learning Based Vision Transformer for Medical Image Classification
Image classification, a fundamental task in computer vision, faces challenges concerning limited data handling, interpretability, improved feature...
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Clinical trial results in context: comparison of baseline characteristics and outcomes of 38,510 RECOVERY trial participants versus a reference population of 346,271 people hospitalised with COVID-19 in England
BackgroundRandomised trials are essential to reliably assess medical interventions. Nevertheless, interpretation of such studies, particularly when...
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A bias-reduced generalized estimating equation approach for proportional odds models with small-sample longitudinal ordinal data
BackgroundLongitudinal ordinal data are commonly analyzed using a marginal proportional odds model for relating ordinal outcomes to covariates in the...
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Impact of an intergenerational program to improve loneliness and social isolation in older adults initiated at the time of emergency department discharge: study protocol for a three-arm randomized clinical trial
BackgroundSocial isolation and loneliness (SIL) worsens mortality and other outcomes among older adults as much as smoking. We previously tested the...
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Cognitive training and promoting a healthy lifestyle for individuals with isolated REM sleep behavior disorder: study protocol of the delayed-start randomized controlled trial CogTrAiL-RBD
BackgroundIsolated REM sleep behavior disorder (iRBD) is an early α-synucleinopathy often accompanied by incipient cognitive impairment. As executive...
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Comparative effectiveness of an individualized model of hemodialysis vs conventional hemodialysis: a study protocol for a multicenter randomized controlled trial (the TwoPlus trial)
BackgroundMost patients starting chronic in-center hemodialysis (HD) receive conventional hemodialysis (CHD) with three sessions per week targeting...
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Evaluating the effectiveness of early urethral catheter removal combined with intermittent catheterization for promoting early recovery of bladder function after laparoscopic radical hysterectomy: a study protocol for a randomized controlled trial
BackgroundBladder dysfunction, notably urinary retention, emerges as a significant complication for cervical cancer patients following radical...
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Evolution and implications of SARS-CoV-2 variants in the post-pandemic era
SARS-CoV-2, the cause of the COVID-19 pandemic, has introduced a challenging era characterized by the persistent emergence of subvariants. Even after...
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Copenhagen Mesenteric stent study (COMESS)—a randomized trial of stent versus covered stent treatment for chronic mesenteric ischemia
BackgroundCurrent management of mesenteric ischemia is primarily endovascular stent treatment. Typical CMI symptoms are postprandial abdominal pain,...
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Determining the extent and frequency of on-site monitoring: a bayesian risk-based approach
BackgroundOn-site monitoring is a crucial component of quality control in clinical trials. However, many cast doubt on its cost-effectiveness due to...
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Biomarker Driven Antifungal Stewardship (BioDriveAFS) in acute leukaemia—a multi-centre randomised controlled trial to assess clinical and cost effectiveness: a study protocol for a randomised controlled trial
BackgroundAcute leukaemias (AL) are life-threatening blood cancers that can be potentially cured with treatment involving myelosuppressive,...
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Randomized controlled trial of enteral vitamin D supplementation (ViDES) in infants <28 weeks gestational age or <1000 g birth weight: study protocol
BackgroundVitamin D is necessary to develop healthy lungs and other organs early in life. Most infants born before 28 weeks’ gestation have low...
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Volatile vs Total intravenous Anaesthesia for major non-cardiac surgery: a pragmatic randomised triaL (VITAL)
BackgroundImproving outcomes after surgery is a major public health research priority for patients, clinicians and the NHS. The greatest burden of...
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Is casting of displaced paediatric distal forearm fractures non-inferior to reduction under general anaesthesia? Study protocol for a pragmatic, randomized, controlled non-inferiority multicentre trial (the casting trial)
BackgroundTreatment of displaced distal forearm fractures in children has traditionally been closed reduction and pin fixation, although they might...
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Virtual reality cue-exposure therapy in reducing cocaine craving: the Promoting Innovative COgnitive behavioral therapy for Cocaine use disorder (PICOC) study protocol for a randomized controlled trial
BackgroundCocaine craving is a central symptom of cocaine use disorders (CUD). Virtual reality cue-exposure therapy for craving (VRCET) allows more...
