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Clinical efficacy of a new therapeutic option for lower genital tract lesions: 5-ALA photodynamic therapy
The study utilized 5-ALA-PDT to treat patients with CIN or VaIN and assessed their clinical response, HPV clearance, and influencing factors after...
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Participants’ perspectives of being recruited into a randomised trial of a weight loss intervention before colorectal cancer surgery: a qualitative interview study
BackgroundThe period between cancer diagnosis and surgery presents an opportunity for trials to assess the feasibility of behaviour change...
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Establishment of an ovarian cancer exhausted CD8+T cells-related genes model by integrated analysis of scRNA-seq and bulk RNA-seq
Ovarian cancer (OC) was the fifth leading cause of cancer death and the deadliest gynecological cancer in women. This was largely attributed to its...
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Predictors of daytime blood pressure, nighttime blood pressure, and nocturnal dip** in patients with chronic kidney disease
Increasing attention has recently been paid to discrepancies between office and ambulatory blood pressure (BP) control in patients with chronic...
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A taxonomy of demand-driven questions for use by evidence producers, intermediaries and decision-makers: results from a cross-sectional survey
BackgroundGlobally, a growing number of calls to formalize and strengthen evidence-support systems have been released, all of which emphasize the...
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Factors related with lung functions among Orang Asli in Tasik Chini, Malaysia: a cross-sectional study
BackgroundOrang Asli lifestyle and household setting may influence their health status especially respiratory system and lung functions. This...
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Clinical outcome predictors for metastatic renal cell carcinoma: a retrospective multicenter real-life case series
Over the last decades, the therapeutic armamentarium of metastatic renal cell carcinoma (mRCC) has been revolutionized by the advent of...
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The effect of transcranial alternating current stimulation on cognitive flexibility and attention of children with intellectual disability: a case report
BackgroundIntellectual disability is a neurodevelopmental disorder characterized by significant impairments in intellectual functioning and adaptive...
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Exploring the causal association between uric acid and lung cancer in east Asian and European populations: a mendelian randomization study
BackgroundLung cancer still ranks first in the mortality rate of cancer. Uric acid is a product of purine metabolism in humans. Its presence in the...
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Receiving home care forms and the risk for emergency department visits in community-dwelling Dutch older adults, a retrospective cohort study using national data
BackgroundOlder adults receiving home care have a higher risk of visiting the emergency department (ED) than community-dwelling older adults not...
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Assessing the value and knowledge gains from an online tick identification and tick-borne disease management course for the Southeastern United States
BackgroundTick-borne diseases are a growing public health threat in the United States. Despite the prevalence and rising burden of tick-borne...
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Changes in Illicit Drug Use Among High School Students in Southeastern U.S. States—2009 to 2019
To determine if decreasing lifetime use of methamphetamines, cocaine, ecstasy, and inhalants among high school students occurring from 2009 to 2019...
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Determinants of mortality status and population attributable risk fractions of the North West Province, South African site of the international PURE study
BackgroundMortality data and comparative risk assessments from sub-Saharan Africa are limited. There is an urgent need for high quality population...
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Assessing the impact of COVID-19 on routine immunization in Sierra Leone
BackgroundThe COVID-19 pandemic had a profound impact on healthcare systems and services, including routine immunization (RI). To date, there is...
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Analysis of Phenotypes Associated with Deficiency of PAX6 Haplotypes in Chinese Aniridia Families
ObjectiveTo examine the clinical phenotype and genetic deficiencies present in Chinese aniridia families with PAX6 haplotype deficiency.
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Association between life’s essential 8 and metabolic dysfunction-associated steatotic liver disease among US adults
BackgroundMetabolic dysfunction-associated steatotic liver disease(MASLD) is the most common cause of chronic liver disease. Clinical evidences have...
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Oncogenic dependency on SWI/SNF chromatin remodeling factors in T-cell acute lymphoblastic leukemia
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological malignancy arising from immature thymocytes. Unlike well-known oncogenic transcription...
