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Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization
Early diagnosis of head and neck cancer can improve therapeutic outcomes but remains a challenge. The blood proteome can comprise a key source of...
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Investigating the Impact of Intracerebroventricular Streptozotocin on Female Rats with and without Ovaries: Implications for Alzheimer’s Disease
To contribute to research on female models of Alzheimer’s disease (AD), our aim was to study the effect of intracerebroventricular (ICV) injection of...
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Improving Likert scale big data analysis in psychometric health economics: reliability of the new compositional data approach
Bipolar psychometric scales data are widely used in psychologic healthcare. Adequate psychological profiling benefits patients and saves time and...
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Use of cortical hemodynamic responses in digital therapeutics for upper limb rehabilitation in patients with stroke
BackgroundStroke causes long-term disabilities, highlighting the need for innovative rehabilitation strategies for reducing residual impairments....
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Efficacy and safety of direct oral anticoagulants versus warfarin in the treatment of cerebral venous sinus thrombosis
BackgroundGiven the evolving application and promising outcomes of direct oral anticoagulants (DOACs) in various thromboembolic conditions, we aimed...
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Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer’s disease pathology in the population?
BackgroundWhite matter hyperintensities (WMH) are considered hallmark features of cerebral small vessel disease and have recently been linked to...
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The Role of the Intestinal Flora and Its Derivatives in Neurocognitive Disorders: A Narrative Review from Surgical Perspective
Perioperative neurocognitive dysfunction is a significant concern for population health, impacting postoperative recovery and increasing the...
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Revised cardiac risk index in predicting cardiovascular complications in patients receiving chronic kidney replacement therapy undergoing elective general surgery
IntroductionThe Revised Cardiac Risk Index (RCRI) is a six-parameter model that is commonly used in assessing individual 30-day perioperative...
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A critical appraisal on the involvement of plant-based extracts as neuroprotective agents (2012–2022): an effort to ease out decision-making process for researchers
The purpose of this review study is to provide a condensed compilation of 164 medicinal plants that have been investigated for their neuroprotective...
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Efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population with type 2 diabetes uncontrolled with metformin: PIONEER 12, a double-blind, Phase IIIa, randomised trial
Aims/hypothesisThe aim of this study was to assess the efficacy and safety of oral semaglutide vs sitagliptin in a predominantly Chinese population...
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Establishment of a trastuzumab-resistant extramammary Paget disease model: loss of PTEN as a potential mechanism
Background/objectivesExtramammary Paget disease (EMPD) is a rare, cutaneous intraepithelial adenocarcinoma typically treated with wide local...
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In the Eye of the Beholder: Visualizing Strengths, Burdens and Desires Through the Lens of Neurodivergent Children, Their Parents, and Professionals Using the Yucel Method
ObjectivesIn mental healthcare, there is a growing emphasis on one’s strengths and context instead of focusing primarily on individual deficiencies,...
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Elevated serum kynurenic acid in individuals with first-episode psychosis and insufficient response to antipsychotics
The tryptophan-metabolizing kynurenine pathway (KP) can be activated by enhanced inflammatory responses and has been implicated in the...
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Antiferromagnetic artificial neuron modeling of the withdrawal reflex
Replicating neural responses observed in biological systems using artificial neural networks holds significant promise in the fields of medicine and...
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CREB-Binding Protein Regulates Cocaine- and Amphetamine-Regulated Transcript Peptide Expression in the Lateral Hypothalamus: Implication in Reward and Reinforcement
Neuropeptide cocaine- and amphetamine-regulated transcript peptide (CARTp) is known to play an important role in reward processing. The rats...
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Research hotspots and trends of spinal cord stimulation for neuropathic pain: a bibliometric analysis from 2004 to 2023
The purpose of this study is to systematically analyze the development trend, research hotspots, and future development direction on the treatment of...