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Applying a User-Centered Design Framework to Develop a Remote Research Assessment Protocol for a Randomized Clinical Trial for Toddlers with Early Autism Characteristics
COVID-19 required many research teams to shift from in-person to remote assessments, which posed both procedural and theoretical challenges. While...
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Radiomics model based on dual-energy CT can determine the source of thrombus in strokes with middle cerebral artery occlusion
PurposeTo develop thrombus radiomics models based on dual-energy CT (DECT) for predicting etiologic cause of stroke.
MethodsWe retrospectively...
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Spinal dementia: Don’t miss it, it’s treatable
Background & purposeAround 5% of dementia patients have a treatable cause. To estimate the prevalence of two rare diseases, in which the treatable...
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Glycogenolysis-Induced Astrocytic Ser**1 Expression Regulates Neuroinflammatory Effects on Hippocampal neuron
The bacterial pathogen, lipopolysaccharide (LPS), elicits microglial response and induces cytokine secretion that subsequently activates astrocytes....
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Greater Self-reported Health is Associated with Lower Disgust: Evidence for Individual Calibration of the Behavioral Immune System
A key theoretical component of the behavioral immune system is its functional flexibility, where an individual’s reaction to pathogenic stimuli is...
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An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets
BackgroundInclusion bodies (IBs) are well-known subcellular structures in bacteria where protein aggregates are collected. Various methods have...
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The obesity-related mutation gene on nonalcoholic fatty liver disease
The prevalence of overweight and obesity is increasing, leading to metabolic-associated fatty liver disease (MAFLD) characterized by excessive...
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In silico-guided discovery and in vitro validation of novel sugar-tethered lysinated carbon nanotubes for targeted drug delivery of doxorubicin
ContextMultiwalled carbon nanotubes (MWCNTs) functionalized with lysine via 1,3-dipolar cycloaddition and conjugated to galactose or mannose are...
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Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission
Segmental bone defects, arising from factors such as trauma, tumor resection, and congenital malformations, present significant clinical challenges...
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Imaging features of pediatric meningiomas: emphasis on unusual locations
PurposeThis article aims to analyze pediatric meningioma’s imaging characteristics, especially those in unusual locations.
MethodsPediatric patients...
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Clarifying middle authorship contributions to reduce abuses in science publishing and assessment of top-ranked SJR biochemistry and pharmacology journals’ authorship criteria
So-called “middle authors,” being neither the first, last, nor corresponding author of an academic paper, have made increasing relative contributions...
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The quassinoids bruceines A–M: pharmacology, mechanism of action, synthetic advance, and pharmacokinetics—a review
Bruceines A–L are among the quassinoid representatives found in the medicinal plant Brucea javanica (L.). An overview of their pharmacological...
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Efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese population with type 2 diabetes (PIONEER 11): a double-blind, Phase IIIa, randomised trial
Aims/hypothesisThe aim of this study was to evaluate the efficacy and safety of oral semaglutide monotherapy vs placebo in a predominantly Chinese...
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Strategies for modeling aging and age-related diseases
The ability to reprogram patient-derived-somatic cells to IPSCs (Induced Pluripotent Stem Cells) has led to a better understanding of aging and...
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Differences in spatiotemporal brain network dynamics of Montessori and traditionally schooled students
Across development, experience has a strong impact on the way we think and adapt. School experience affects academic and social-emotional outcomes,...
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Awake craniotomy in pediatric low-grade glioma: barriers and future directions
IntroductionThe goal of surgical management in pediatric low-grade gliomas (pLGGs) is gross total resection (GTR), as it is considered curative with...
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Exploratory Mass Spectrometry of Cerebrospinal Fluid from Persons with Autopsy-Confirmed LATE-NC
Common neuropathologies associated with dementia include Alzheimer’s disease neuropathologic change (ADNC) and limbic-predominant age-related TDP-43...
