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Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury
BackgroundSpinal cord injury (SCI) disrupts intestinal barrier function, thereby increasing antigen permeation and leading to poor outcomes. Despite...
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Targeting the pancreatic tumor microenvironment by plant-derived products and their nanoformulations
Pancreatic cancer remains a significant health issue with limited treatment options. The tumor stroma, a complex environment made up of different...
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Psoriatic Arthritis Acceptable Symptoms State: Does Sex Make a Difference?
IntroductionThe Patient Acceptable Symptoms State (PASS) is a validated instrument that is used to assess whether a patient with psoriatic arthritis...
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Targeting CERS6-AS1/FGFR1 axis as synthetic vulnerability to constrain stromal cells supported proliferation in Mantle cell lymphoma
The interaction between stromal and tumor cells in tumor microenvironment is a crucial factor in Mantle cell lymphoma (MCL) progression and therapy...
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Targeting CD73 limits tumor progression and enhances anti-tumor activity of anti-PD-1 therapy in intrahepatic cholangiocarcinoma
Background & aimsPatients with intrahepatic cholangiocarcinoma (iCCA) respond poorly to immune checkpoint blockades (ICBs). In this study, we aimed...
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Novel Vpx virus-like particles to improve cytarabine treatment response against acute myeloid leukemia
Knowledge of the molecular pathogenesis of acute myeloid leukemia has advanced in recent years. Despite novel treatment options, acute myeloid...
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Bloodstream infections due to multi-drug resistant bacteria in the emergency department: prevalence, risk factors and outcomes—a retrospective observational study
Multidrug-resistant organisms (MDROs) are prevalent in patients admitted to the Emergency Department (ED) and increase the risk of inappropriate...
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LncRNA PITPNA-AS1 mediates the diagnostic potential of miR-129-5p in prostate cancer
BackgroundLncRNA has an effective value in many diseases, which has long been applied in the diagnosis, treatment and prognosis of prostate cancer....
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Uric acid to albumin ratio as a novel predictor for coronary slow flow phenomenon in patients with chronic coronary syndrome and non-obstructive coronary arteries
BackgroundThe plasma uric acid to albumin ratio (UAR) is considered as a novel indicator for Inflammation. However, the association between UAR and...
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Hemorrhagic shock from gastric pseudoaneurysm post-percutaneous endoscopic gastrostomy: a case report
Percutaneous endoscopic gastrostomy (PEG) is widely used for long-term enteral nutrition in patients unable to maintain adequate oral intake. Despite...
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RET Inhibitors in RET Fusion-Positive Lung Cancers: Past, Present, and Future
While activating RET fusions are identified in various cancers, lung cancer represents the most common RET fusion-positive tumor. The clinical drug...
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Healthcare costs and medical utilization patterns associated with painful and severe painful diabetic peripheral neuropathy
PurposePainful diabetic peripheral neuropathy (DPN) is a common complication in patients with diabetes. It is associated with a poor quality of life...
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Consensus paper on the management of acute isolated vertigo in the emergency department
Acute vertigo is defined as the perception of movement of oneself or the surroundings in the absence of actual motion and it is a frequent cause for...
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Elemental Diet as a Therapeutic Modality: A Comprehensive Review
Elemental diets have been employed for the management of various diseases for over 50 years, with several mechanisms mediating their beneficial...
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LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway
PurposeLong noncoding RNAs (lncRNAs) exert a significant influence on various cancer-related processes through their intricate interactions with...
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Development and validation of nomogram for predicting the risk of transferring to the ICU for children with influenza
ObjectiveDevelopment of a nomogram model for predicting the magnitude of risk of transferring hospitalized children with influenza to the ICU.
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Targeting DNA Damage Response Deficiency in Thoracic Cancers
Thoracic cancers comprise non-small cell lung cancers (NSCLCs), small cell lung cancers (SCLCs) and malignant pleural mesotheliomas (MPM)....
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Development and validation of AI-derived segmentation of four-chamber cine cardiac magnetic resonance
BackgroundCardiac magnetic resonance (CMR) in the four-chamber plane offers comprehensive insight into the volumetrics of the heart. We aimed to...
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Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases
Mitotic catastrophe (MC), which occurs under dysregulated mitosis, represents a fascinating tactic to specifically eradicate tumor cells. Whether...