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Heavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics
PurposeCancer registries offer an avenue to identify cancer clusters across large populations and efficiently examine potential environmental harms...
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How risky is a second allogeneic stem cell transplantation?
There is no consensus on second allogeneic stem cell transplantation (alloSCT) indications in patients with hematologic malignancies relapsing after...
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Genipin’s potential as an anti-cancer agent: from phytochemical origins to clinical prospects
This comprehensive review delves into the multifaceted aspects of genipin, a bioactive compound derived from medicinal plants, focusing on its...
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Efficacy and safety of ruxolitinib in the treatment of chronic graft-versus-host disease: a retrospective analysis
Steroid-refractory chronic graft-versus-host disease (cGvHD) is associated with significant morbidity and mortality, with ruxolitinib being the first...
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A drug repurposing study identifies novel FOXM1 inhibitors with in vitro activity against breast cancer cells
FOXM1, a proto-oncogenic transcription factor, plays a critical role in cancer development and treatment resistance in cancers, particularly in...
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MEX3A promotes colorectal cancer migration, invasion and EMT via regulating the Wnt/β-catenin signaling pathway
BackgroundMex-3 RNA binding family members are well-established to be important in cancer development and progression. However, the functions of...
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Spectrum and characteristics of germline PALB2 pathogenic variants in 1556 early-onset breast cancer patients in China
PurposeLimited data are available regarding the partner and localizer of BRCA2 ( PALB2 ) in Chinese patients with early breast cancer. This study...
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Identified γ-glutamyl cyclotransferase (GGCT) as a novel regulator in the progression and immunotherapy of pancreatic ductal adenocarcinoma through multi-omics analysis and experiments
BackgroundPancreatic ductal adenocarcinoma (PDAC) is renowned for its formidable and lethal nature, earning it a notorious reputation among malignant...
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Enhancing hepatocellular carcinoma management: prognostic value of integrated CCL17, CCR4, CD73, and HHLA2 expression analysis
PurposeHepatocellular carcinoma (HCC) is a critical global health concern, with existing treatments benefiting only a minority of patients. Recent...
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The role of IL-17 in the pathogenesis and treatment of glioblastoma—an update on the state of the art and future perspectives
Glioblastoma (GBM) is the most common malignant brain tumor, which, despite significant progress made in the last years in the field of...
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Early reappearance of intraclonal proliferative subpopulations in ibrutinib-resistant chronic lymphocytic leukemia
The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib represents an effective strategy for treatment of chronic lymphocytic leukemia (CLL),...
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Molecular characterization of a rare case of high-grade B-cell lymphoma with MYC, BCL2, BCL6, and CCND1 rearrangements
Quadruple-hit lymphomas are extremely rare non-Hodgkin lymphomas with a reported dismal prognosis in the few reported cases. A “quadruple hit” has...
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Amino acid influx via LAT1 regulates iron demand and sensitivity to PPMX-T003 of aggressive natural killer cell leukemia
Aggressive natural killer cell leukemia (ANKL) is a rare hematological malignancy with a fulminant clinical course. Our previous study revealed that...
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LINC00525 enhances ZNF460-regulated CD24 expression through the sponge miR-125a-5p to promote malignant progression of breast cancer
IntroductionCD24 is a highly glycosylated glycosylphosphatidylinositol anchored membrane protein that plays an important role in tumor progression....
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Genoty** R1336X and Eliminating the Pseudogene Amplification in Type 3 von Willebrand Disease Patients
Among inherited bleeding disorders, von Willebrand disease (VWD) is the most common disease worldwide. Type 3, the most severe form, is more...
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Post-transplant cyclophosphamide compared to sirolimus/tacrolimus in reduced intensity conditioning transplants for patients with lymphoid malignancies
Despite novel cellular and immunomodulatory therapies, allogeneic hematopoietic stem cell transplantation (HSCT) remains a treatment option for...
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Liver cancer from the perspective of single-cell sequencing: a review combined with bibliometric analysis
BackgroundLiver cancer (LC) is a prevalent malignancy and a leading cause of cancer-related mortality worldwide. Extensive research has been...
