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Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...
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The resistance switching performance of the memristor improved effectively by inserting carbon quantum dots (CQDs) for digital information processing
As an emerging information device that adapts to development of the big data era, memristor has attracted much attention due to its advantage in...
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Psychological and ethical issues raised by genomic in paediatric care pathway, a qualitative analysis with parents and childhood cancer patients
In paediatric oncology, genomics raises new ethical, legal and psychological issues, as somatic and constitutional situations intersect throughout...
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Dielectric nanocomposites with superb high-temperature capacitive performance based on high intrinsic dielectric constant polymer
Advancements in power electronics necessitate dielectric polymer films capable of operating at high temperatures and possessing high energy density....
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Death anxiety among caregivers of patients with advanced cancer: a cross-sectional survey
PurposeThis study aimed to investigate death anxiety (DA) in caregivers of patients with advanced cancer and identify associated factors in the...
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Safety and Efficacy of Covered Self-Expandable Metallic Stent for Choledochojejunal Anastomotic Stricture: A Multi-Center Retrospective Cohort Study
BackgroundBenign choledochojejunal anastomotic stricture (CJS) is a complication of pancreaticoduodenectomy and choledochojejunostomy. Typically...
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Deep learning model based on endoscopic images predicting treatment response in locally advanced rectal cancer undergo neoadjuvant chemoradiotherapy: a multicenter study
PurposeNeoadjuvant chemoradiotherapy has been the standard practice for patients with locally advanced rectal cancer. However, the treatment response...
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Neuroprotective and vasoprotective effects of herb pair of Zhiqiao-Danggui in ischemic stroke uncovered by LC-MS/MS-based metabolomics approach
Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine...
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Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis
BackgroundAge-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus...
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Carbon-ion radiotherapy alone vs. standard dose photon radiation with carbon-ion radiotherapy boost for high-grade gliomas: a retrospective study
BackgroundThis study aimed to compare the survival outcome and side effects in patients with primary high-grade glioma (HGG) who received carbon ion...
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Hyponatremia Is Associated with Mortality in Acute Pancreatitis Patients
BackgroundDisorders of serum sodium are common among general patients and are associated with poor outcomes. The prognostic value of serum sodium...
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A glimpse into viral warfare: decoding the intriguing role of highly pathogenic coronavirus proteins in apoptosis regulation
Coronaviruses employ various strategies for survival, among which the activation of endogenous or exogenous apoptosis stands out, with viral proteins...
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Therapeutic nucleic acids in regenerative medicine and tissue repair
In the vanguard of biomedical innovation, regenerative medicine emerges as a transformative paradigm, concentrating its efforts on rectifying tissue...
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Intricate effects of post-translational modifications in liver cancer: mechanisms to clinical applications
Liver cancer is a significant global health challenge, with hepatocellular carcinoma (HCC) being the most prevalent form, characterized by high...
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Fluorescence Recognition of Hydrazine Driven by Neighboring Group Participation
Hydrazine (N 2 H 4 ) has toxic effects on the environment. Although a variety of reactive probes have been used to identify hydrazine, practical...
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Statins for the Primary Prevention of Anthracycline Cardiotoxicity: A Comprehensive Review
Purpose of ReviewThe aim of this review is two-fold: (1) To examine the mechanisms by which statins may protect from anthracycline-induced...
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Lessons Learned Implementing Syringe Services Programs at Rural Health Departments in Kentucky
Until recently, most syringe services programs (SSPs) in the United States operated in metropolitan areas. This study explores how SSP implementers...
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Reducing racial and ethnic disparities in cardiovascular outcomes among cancer survivors
Purpose of reviewAnalyze current evidence on racial/ethnic disparities in cardiovascular outcomes among cancer survivors, identifying factors and...
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GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
BackgroundAcetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116)...
