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miR-338-5p regulated the NF-κB/MAPK pathway to alleviate inflammation and oxidative stress by targeting IL-6 in rats with atrial fibrillation
The aim of this study was to investigate the functional effect of miR-338-5p targeting IL-6 on NF-κB/MAPK pathway-mediated inflammation and oxidative...
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Rare variants at KCNJ2 are associated with LDL-cholesterol levels in a cross-population study
Leveraging whole genome sequencing data of 1751 individuals from the UK and 2587 Qatari subjects, we suggest here an association of rare variants...
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Multi-modal Bionic Motion Analysis of A Cpg-controlled Pneumatic Soft Robot
This paper designs a soft robot with a multi-chamber, multi-airbag mimicking soft biological structure, where the airbags of the same chamber are...
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Revolutionizing cultural heritage preservation: an innovative IoT-based framework for protecting historical buildings
Italy offers a cultural heritage of considerable value that needs to be protected. Indeed, natural deterioration linked to the passage of time...
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Network pharmacology and experimental validation to explore the anti-aging mechanism of action of betulinic acid
This subject aims to investigate the potential targets and mechanism of action of betulinic acid in anti-aging through network pharmacology,...
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penalizedclr: an R package for penalized conditional logistic regression for integration of multiple omics layers
BackgroundThe matched case–control design, up until recently mostly pertinent to epidemiological studies, is becoming customary in biomedical...
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Integrated multi-omics analysis and machine learning to refine molecular subtypes, prognosis, and immunotherapy in lung adenocarcinoma
Lung adenocarcinoma (LUAD) has a malignant characteristic that is highly aggressive and prone to metastasis. There is still a lack of suitable...
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EU surveys insights: analytical tools, future directions, and the essential requirement for reference materials in wastewater monitoring of SARS-CoV-2, antimicrobial resistance and beyond
BackgroundWastewater surveillance (WWS) acts as a vigilant sentinel system for communities, analysing sewage to protect public health by detecting...
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Using proximity loggers in studies of sheep behavior: an estimation of the daily frequency of water consumption
BackgroundProximity loggers are a biotelemetry technology used to quantify animal–animal interactions non-invasively. They are small devices can be...
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Clinical spectrum of rare bone fragility disorders and response to bisphosphonate treatment: a retrospective study
Osteogenesis Imperfecta (OI) is a clinically and genetically heterogeneous group of diseases characterized by brittle bones. Though genetic mutations...
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Can large language models understand molecules?
PurposeLarge Language Models (LLMs) like Generative Pre-trained Transformer (GPT) from OpenAI and LLaMA (Large Language Model Meta AI) from Meta AI...
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Full Hill-type muscle model of the I1/I3 retractor muscle complex in Aplysia californica
The coordination of complex behavior requires knowledge of both neural dynamics and the mechanics of the periphery. The feeding system of Aplysia...
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Investigation of missense mutation-related type 1 diabetes mellitus through integrating genomic databases and bioinformatic approach
Though genes are already known to be responsible for type 1 diabetes mellitus (T1DM), the knowledge of missense mutation of that disease gene has...
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Exploring molecular targets: herbal isolates in cervical cancer therapy
ObjectiveCervical cancer (CxCa) stands as a significant global health challenge, ranking fourth in cancer-related mortality among the female...
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Severity in the genomic age: the significance of lived experience to understandings of severity
This article explores the significance of lived experience to understandings of severity in the genomic age. It draws upon data from structured...
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Sensitivity and Specificity versus Precision and Recall, and Related Dilemmas
Many evaluations of binary classifiers begin by adopting a pair of indicators, most often sensitivity and specificity or precision and recall....
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Computational Tools for Neuronal Morphometric Analysis: A Systematic Search and Review
Morphometry is fundamental for studying and correlating neuronal morphology with brain functions. With increasing computational power, it is possible...
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Immune evasion impacts the landscape of driver genes during cancer evolution
BackgroundCarcinogenesis is driven by interactions between genetic mutations and the local tumor microenvironment. Recent research has identified...
