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Screening of Candida spp. in wastewater in Brazil during COVID-19 pandemic: workflow for monitoring fungal pathogens
Fungal diseases are often linked to poverty, which is associated with poor hygiene and sanitation conditions that have been severely worsened by the...
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Optimizing Nimesulide Loaded Cubosomal Gel for Enhanced Efficacy: A Systematic Engineering Approach with Factorial Design for Topical Applications
PurposeThe primary aim of this study is to develop a cubosome nanoformulation for the optimized delivery of nimesulide, with a focus on improving its...
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Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
Sterol-binding proteins are important regulators of lipid homeostasis and membrane integrity; however, the discovery of selective modulators can be...
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The power and pitfalls of AlphaFold2 for structure prediction beyond rigid globular proteins
Artificial intelligence-driven advances in protein structure prediction in recent years have raised the question: has the protein...
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Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
Metabolic alterations in cancer precipitate in associated dependencies that can be therapeutically exploited. To meet this goal, natural...
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Rationally seeded computational protein design of ɑ-helical barrels
Computational protein design is advancing rapidly. Here we describe efficient routes starting from validated parallel and antiparallel peptide...
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Defining the Range of Calibration Burden: From Full Calibration to Calibration-Free
The expansion of spectroscopic process analytical technology (PAT) within the pharmaceutical industry requires chemometric models to enable spectral...
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Rare-metal-free hydrogen evolution reaction electrocatalysts based on metal azaphthalocyanine molecular layer for anion exchange membrane water electrolysis
In this report, we elucidated the hydrogen evolution reaction (HER) catalytic activity of different metal-azaphthalocyanine unimolecular layer (AZUL)...
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3-Hydroxykynurenine targets kainate receptors to promote defense against infection
Bacterial infection involves a complex interaction between the pathogen and host where the outcome of infection is not solely determined by pathogen...
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Development and Evaluation of Stable Long Circulating Decitabine-loaded Copolymeric Nanoparticles: Harnessing QbD Approach and Lyophilization Technique
PurposeDecitabine is an inhibitor of DNA methyltransferase used to treat various types of leukemias. However, it is highly unstable in nature thereby...
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Transgenic Arabidopsis thaliana plants expressing bacterial γ-hexachlorocyclohexane dehydrochlorinase LinA
Backgroundγ-Hexachlorocyclohexane (γ-HCH), an organochlorine insecticide of anthropogenic origin, is a persistent organic pollutant (POP) that causes...
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Quantitative control of subcellular protein localization with a photochromic dimerizer
Artificial control of intracellular protein dynamics with high precision provides deep insight into complicated biomolecular networks. Optogenetics...
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Architecture of the RNF1 complex that drives biological nitrogen fixation
Biological nitrogen fixation requires substantial metabolic energy in form of ATP as well as low-potential electrons that must derive from central...
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Reconstructing 3D Biomedical Architectural Order at Multiple Spatial Scales with Multimodal Stack Input
Microscopy, crucial for exploring biological structures, often uses polarizing microscopes to observe tissue anisotropy and reconstruct label-free...
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MAPFUNet: Multi-attention Perception-Fusion U-Net for Liver Tumor Segmentation
The second-leading cause of cancer-related deaths globally is liver cancer. The treatment of liver cancers depends heavily on the accurate...
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Highly Bendable Ionic Electro-responsive Artificial Muscles Using Microfibrillated Cellulose Fibers Combined with Polyvinyl Alcohol
For promising applications such as soft robotics, flexible haptic monitors, and active biomedical devices, it is important to develop ultralow...
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Green biosynthesis of bimetallic ZnO@AuNPs with its formulation into cellulose derivative: biological and environmental applications
Nanoparticles (NPs) formulation in biopolymers is an attractive process for the researcher to decrease the disadvantages of NPs application alone....
