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Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion
BackgroundWe have previously identified an unsuspected role for GJB3 showing that the deficiency of this connexin protein induces aneuploidy in human...
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Clinical exome analysis and targeted gene repair of the c.1354dupT variant in iPSC lines from patients with PROM1-related retinopathies exhibiting diverse phenotypes
BackgroundInherited retinal dystrophies (IRD) are one of the main causes of incurable blindness worldwide. IRD are caused by mutations in genes that...
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Genome-wide identification and expression analysis of histone deacetylase and histone acetyltransferase genes in response to drought in poplars
BackgroundHistone deacetylases (HDACs) and histone acetyltransferases (HATs) are involved in plant growth and development as well as in response to...
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cBAF generates subnucleosomes that expand OCT4 binding and function beyond DNA motifs at enhancers
The canonical BRG/BRM-associated factor (cBAF) complex is essential for chromatin opening at enhancers in mammalian cells. However, the nature of the...
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Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank
Suicide is a global public health challenge, yet considerable uncertainty remains regarding the associations of both behaviour-related and...
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Metabolic complexity drives divergence in microbial communities
Microbial communities are shaped by environmental metabolites, but the principles that govern whether different communities will converge or diverge...
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BI1 Activates Autophagy and Mediates TDP43 to Regulate ALS Pathogenesis
Amyotrophic lateral sclerosis (ALS) is the most prevalent motor neuron disease in adults. Currently, there are no known drugs or clinical approaches...
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In Silico Drug Repurposing Against PSMB8 as a Potential Target for Acute Myeloid Leukemia Treatment
PSMB8 emerges as a prominent gene associated with cancer survival, yet its potential therapeutic role in acute myeloid leukemia (AML) remains...
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Respiratory Function of Mitochondria in Patients with Coronary Heart Disease with Implantable Cardioverter-Defibrillator
We studied the respiratory activity of mitochondria in peripheral blood leukocytes from 36 patients with coronary heart disease (CHD) and a history...
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Comprehensive approach to in silico identification and in vitro validation of anti-filarial hit molecules targeting the dimer interface of thioredoxin peroxidase 1 in Wuchereria bancrofti: a progress in anti-filariasis drug development
Lymphatic filariasis (LF) remains a significant health challenge for populations in develo** countries. LF is a parasitic disease transmitted by...
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Hodgkin lymphoma and liquid biopsy: a story to be told
Hodgkin lymphoma (HL) represents a neoplasm primarily affecting adolescents and young adults, necessitating the development of precise diagnostic and...
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Economic and Technical Assessment of the Chinese Plum Varieties Using Multi-Criteria Analysis Methods
Globally, plums are among the most grown and consumed fruit species. Considering China as the leader in plum production, there are intentions to...
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Pharmacological Inhibition or Silencing of TREM1 Restrains HCC Cell Metastasis by Inactivating TLR/PI3K/AKT Signaling
Hepatocellular carcinoma (HCC), a widely prevalent malignancy strongly linked to inflammation, remains a significant public health concern....
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Manipulating disorder within cathodes of alkali-ion batteries
The fact that ordered materials are rarely perfectly crystalline is widely acknowledged among materials scientists, but its impact is often...
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Antiplatelet and Antithrombotic Properties of Compound L-36, a 6H-1,3,4-Thiadiazine Derivative
Compound L-36, a new derivative of 6 H -1,3,4-thiadiazine, was studied in in vitro and in vivo experiments. This compound exhibits high antiplatelet...
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Fluorescence lifetime multiplexing with fluorogen activating protein FAST variants
In this paper, we propose a fluorescence-lifetime imaging microscopy (FLIM) multiplexing system based on the fluorogen-activating protein FAST. This...
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Red cabbage extract immobilized in bacterial cellulose film as an eco-friendly sensor to monitor microbial contamination and gamma irradiation of stored cucumbers
The aim of the present study is to develop a pH-sensing biopolymer film based on the immobilization of red cabbage extract (RCE) within bacterial...
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Aging is associated with sex-specific alteration in the expression of genes encoding for neuroestradiol synthesis and signaling proteins in the mouse trigeminal somatosensory input
Pain perception is influenced by sex and aging, with previous studies indicating the involvement of aromatase, the estradiol synthase enzyme, in...
