Search
Search Results
-
Antimicrobial peptides: a novel and natural approach as antibiofouling mediator
Antimicrobial peptides (AMPs) are natural ribosomal synthesized small peptides and are crucial effectors in all living organisms. AMPs are diverse...
-
Cryptic enzymatic assembly of peptides armed with β-lactone warheads
Nature has evolved biosynthetic pathways to molecules possessing reactive warheads that inspired the development of many therapeutic agents,...
-
VAMP2 regulates phase separation of α-synuclein
α-Synuclein (αSYN), a pivotal synaptic protein implicated in synucleinopathies such as Parkinson’s disease and Lewy body dementia, undergoes protein...
-
Transition transferases prime bacterial capsule polymerization
Capsules are long-chain carbohydrate polymers that envelop the surfaces of many bacteria, protecting them from host immune responses. Capsule...
-
VAMP2 chaperones α-synuclein in synaptic vesicle co-condensates
α-Synuclein (α-Syn) aggregation is closely associated with Parkinson’s disease neuropathology. Physiologically, α-Syn promotes synaptic vesicle (SV)...
-
Ras suppression potentiates rear actomyosin contractility-driven cell polarization and migration
Ras has been extensively studied as a promoter of cell proliferation, whereas few studies have explored its role in migration. To investigate the...
-
Long-acting Erwinia chrysanthemi, Pegcrisantaspase, induces alternate amino acid biosynthetic pathways in a preclinical model of pancreatic ductal adenocarcinoma
BackgroundPancreatic ductal adenocarcinoma (PDAC) is an aggressive disease without meaningful therapeutic options beyond the first salvage therapy....
-
The Role of Alpha-Synuclein in Neurodevelopmental Diseases
Neurodevelopmental disorders are a group of diseases with cognitive, motor, and emotional development deficits. Alpha-synuclein (α-syn) is a synaptic...
-
Thioclava litoralis sp. nov., a novel species of alphaproteobacterium, isolated from surface seawater
A Gram-negative, aerobic, rod-shaped, non-motile bacterium, designated as FTW29 T , was isolated from surface seawater sampled in Futian district,...
-
Entry of ZSWIM4 to the nucleus is crucial for its inhibition of KIT and BMAL1 in gastrointestinal stromal tumors
BackgroundZinc finger SWIM-type containing 4 (ZSWIM4) is a zinc finger protein with its function largely uncharacterized. In this study, we aimed to...
-
Effect of cross-platform gene-expression, computational methods on breast cancer subty** in PALOMA-2 and PALLET studies
Intrinsic breast cancer molecular subty** (IBCMS) provides significant prognostic information for patients with breast cancer and helps determine...
-
Thonzonium bromide inhibits progression of malignant pleural mesothelioma through regulation of ERK1/2 and p38 pathways and mitochondrial uncoupling
BackgroundMalignant Pleural Mesothelioma (MPM) is a rare malignancy with a poor prognosis. Current therapies are unsatisfactory and novel cures are...
-
TRIM65 deficiency alleviates renal fibrosis through NUDT21-mediated alternative polyadenylation
Chronic kidney disease (CKD) is a major global health concern and the third leading cause of premature death. Renal fibrosis is the primary process...
-
STAMBP is Required for Long-Term Maintenance of Neural Progenitor Cells Derived from hESCs
Mutations in STAMBP have been well-established to cause congenital human microcephaly-capillary malformation (MIC-CAP) syndrome, a rare genetic...
-
Epilepsy Treatment and Diagnosis Enhanced by Current Nanomaterial Innovations: A Comprehensive Review
Epilepsy is a complex disease in the brain. Complete control of seizure has always been a challenge in epilepsy treatment. Currently, clinical...
-
Targeting of 3D oral cancer spheroids by αVβ6 integrin using near-infrared peptide-conjugated IRDye 680
BackgroundIn the treatment of oral cavity cancer, margin status is one of the most critical prognostic factors. Positive margins are associated with...
-
Pleionea litopenaei sp. nov., isolated from the gastric tract of juvenile Pacific white shrimp Litopenaeus vannamei
A Gram-stain-negative, aerobic, rod-shaped and motile strain HL-JVS1 T , was isolated from the gastric tract of a juvenile Pacific white shrimp....
-
Blood-based molecular and cellular biomarkers of early response to neoadjuvant PD-1 blockade in patients with non-small cell lung cancer
BackgroundDespite the improved survival observed in PD-1/PD-L1 blockade therapy, a substantial proportion of cancer patients, including those with...
