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Digital biomarkers for non-motor symptoms in Parkinson’s disease: the state of the art
Digital biomarkers that remotely monitor symptoms have the potential to revolutionize outcome assessments in future disease-modifying trials in...
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Sperm DNA fragmentation and infertility: a narrative review
PurposeThe purpose of this narrative review is to provide a practical understanding of sperm DNA fragmentation (SDF) in the management of male...
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Gastrointestinal Manifestation of MPox
Purpose of ReviewMpox, formerly known as monkeypox, is a zoonotic illness caused by a virus that is part of the Orthopoxvirus family. Originally...
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Prognostic value of surgical resection over biopsy in elderly patients with glioblastoma: a meta-analysis
PurposeMaximal-safe resection has been shown to improve overall survival in elderly patients with glioblastoma in observational studies, however, the...
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A systematic review on the effectiveness of robot-assisted minimally invasive gastrectomy
BackgroundRobot-assisted minimally invasive gastrectomy (RAMIG) is increasingly used as a surgical approach for gastric cancer. This study assessed...
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Clinical characteristics of membranous nephropathy after allogeneic hematopoietic stem cell transplantation: A real-world multicenter study
Membranous nephropathy (MN) is a rare complication that can occur after allogeneic hematopoietic stem cell transplantation (allo-HSCT). MN patients...
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A joint model of longitudinal pharmacokinetic and time-to-event data to study exposure–response relationships: a proof-of-concept study with alectinib
PurposeIn exposure–response analyses of oral targeted anticancer agents, longitudinal plasma trough concentrations are often aggregated into a single...
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Silencing DOCK2 Attenuates Cardiac Fibrosis Following Myocardial Infarction in Mice Via Targeting PI3K/Akt and Wnt/β-Catenin Pathways
Cardiac fibrosis following myocardial infarction (MI) seriously affects the prognosis and survival rate of patients. This study aimed to determine...
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Rationale for Hepatitis C Virus Treatment During Hematopoietic Stem Cell Transplant in the Era of Novel Direct-Acting Antivirals
Background and AimsUntreated hepatitis C (HCV) infection in patients undergoing hematopoietic stem cell transplantation (HSCT) can lead to worse...
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Ensuring People Living with HIV Inform the Future of HIV Treatment in Low- and Middle-Income Countries: A Sco** Review and Recommendations for a Community-Led Research Agenda
The HIV treatment landscape in low- and middle-income countries (LMICs) is rapidly evolving, exemplified by the expansion of differentiated service...
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Anti-cancer potential of casein and its derivatives: novel strategies for cancer treatment
Cancer is one of the leading causes of death worldwide, with over 10 million fatalities annually. While tumors can be surgically removed and treated...
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Efficacy of lengthening right renal veins using accompanying gonadal veins in living donor kidney transplantation
BackgroundShort harvested right renal veins (RV) are quite common in living donor kidney transplantation (KT). This technical difficulty might...
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An adult with hemorrhagic varicella co-infects with cytomegalovirus: a case report
BackgroundHemorrhagic varicella (HV) is a particular form of chicken pox.,with high mortality in adults. This form of the disease is rare, to date,...
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Machine learning to optimize literature screening in medical guideline development
ObjectivesIn a time of exponential growth of new evidence supporting clinical decision-making, combined with a labor-intensive process of selecting...
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NAT10 Overexpression Promotes Tumorigenesis and Epithelial–Mesenchymal Transition Through AKT Pathway in Gastric Cancer
BackgroundN-acetyltransferase 10 (NAT10), the only RNA cytosine acetyltransferase known in humans, contributes to cancer tumorigenesis and...
