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PxBLAT: an efficient python binding library for BLAT
BackgroundWith the surge in genomic data driven by advancements in sequencing technologies, the demand for efficient bioinformatics tools for...
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Leveraging permutation testing to assess confidence in positive-unlabeled learning applied to high-dimensional biological datasets
BackgroundCompared to traditional supervised machine learning approaches employing fully labeled samples, positive-unlabeled (PU) learning techniques...
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First insights into the spatial behaviour of Octopus vulgaris in the wild using acoustic telemetry
Octopuses are amongst the most fascinating animals in our oceans; however, while their intricate behaviours are often studied in laboratory settings,...
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Strain tracking in complex microbiomes using synteny analysis reveals per-species modes of evolution
Microbial species diversify into strains through single-nucleotide mutations and structural changes, such as recombination, insertions and deletions....
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iGenSig-Rx: an integral genomic signature based white-box tool for modeling cancer therapeutic responses using multi-omics data
Multi-omics sequencing is poised to revolutionize clinical care in the coming decade. However, there is a lack of effective and interpretable...
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Evaluation of Genetic Diversity in Gmelina arborea Roxb. Across Different Regions of Gujarat, India: The First Report
Gmelina arborea (G. arborea) , a plant of great medicinal as well as socioeconomic importance renowned for its traditional utilization, lacks prior...
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An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs
BackgroundNeuroblastoma is a common pediatric cancer, where preclinical studies suggest that a mesenchymal-like gene expression program contributes...
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High-throughput volumetric map** of synaptic transmission
Volumetric imaging of synaptic transmission in vivo requires high spatial and high temporal resolution. Sha** the wavefront of two-photon...
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EPI-Trans: an effective transformer-based deep learning model for enhancer promoter interaction prediction
BackgroundRecognition of enhancer–promoter Interactions (EPIs) is crucial for human development. EPIs in the genome play a key role in regulating...
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Application of network pharmacology in synergistic action of Chinese herbal compounds
Herbal medicines are frequently blended in the form of multi-drug combinations primarily based on the precept of medicinal compatibility, to achieve...
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Permittivity tensor imaging: modular label-free imaging of 3D dry mass and 3D orientation at high resolution
The dry mass and the orientation of biomolecules can be imaged without a label by measuring their permittivity tensor (PT), which describes how...
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Quantifying cell-state densities in single-cell phenotypic landscapes using Mellon
Cell-state density characterizes the distribution of cells along phenotypic landscapes and is crucial for unraveling the mechanisms that drive...
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Using GPT-4 to write a scientific review article: a pilot evaluation study
GPT-4, as the most advanced version of OpenAI’s large language models, has attracted widespread attention, rapidly becoming an indispensable AI tool...
