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Myocarditis associated with COVID-19 vaccination
Following the start of the COVID-19 vaccination campaign, the adverse events of myocarditis and pericarditis were linked mainly to mRNA COVID-19...
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Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19
BackgroundAlthough it is well known that the older people have been the most susceptible to COVID-19, there are conflicting data on the...
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Total antioxidant status levels in malaria: a systematic review and meta-analysis
BackgroundMalaria, a severe health threat, significantly affects total antioxidant status (TAS) levels, leading to considerable oxidative stress....
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High prevalence and risk of malaria among asymptomatic individuals from villages with high prevalence of artemisinin partial resistance in Kyerwa district of Kagera region, north-western Tanzania
BackgroundAlthough Tanzania adopted and has been implementing effective interventions to control and eventually eliminate malaria, the disease is...
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Systemic prime mucosal boost significantly increases protective efficacy of bivalent RSV influenza viral vectored vaccine
Although licensed vaccines against influenza virus have been successful in reducing pathogen-mediated disease, they have been less effective at...
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A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity
Persistent infection with high-risk human papillomavirus (HPV) is widely recognized as the primary cause of cervical and other malignant cancers....
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Adoptive NK cell therapy: a potential revolutionary approach in longevity therapeutics
The aging process intricately involves immune system dynamics, with a crucial role in managing senescent cells (SNCs) and their senescence-associated...
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The direct effect of SARS-CoV-2 virus vaccination on human ovarian granulosa cells explains menstrual irregularities
Following administration of the SARS-CoV-2 vaccine, many women worldwide reported short-term menstrual irregularities. Although menstrual bleeding,...
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A gH/gL-encoding replicon vaccine elicits neutralizing antibodies that protect humanized mice against EBV challenge
Epstein-Barr virus (EBV) is associated with several malignancies, neurodegenerative disorders and is the causative agent of infectious mononucleosis....
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Heavy-metal associated breast cancer and colorectal cancer hot spots and their demographic and socioeconomic characteristics
PurposeCancer registries offer an avenue to identify cancer clusters across large populations and efficiently examine potential environmental harms...
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Fine-scale maps of malaria incidence to inform risk stratification in Laos
BackgroundMalaria risk maps are crucial for controlling and eliminating malaria by identifying areas of varying transmission risk. In the Greater...
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Single cell transcriptome analysis identified a unique neutrophil type associated with Alzheimer’s disease
BackgroundNeutrophils play an essential role in Alzheimer’s disease (AD) pathology. However, the extent of their heterogeneity remains poorly...
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Congenital anomalies in Santa Catarina, Southern Brazil: macroregional and temporal birth prevalence for the period 2011–2020
Congenital anomalies (CAs) are an important cause of infant mortality and efficient surveillance is necessary for their prevention. Therefore, the...
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Study of key residues in MERS-CoV and SARS-CoV-2 main proteases for resistance against clinically applied inhibitors nirmatrelvir and ensitrelvir
The Middle East Respiratory Syndrome Coronavirus (MERS-CoV) is an epidemic, zoonotically emerging pathogen initially reported in Saudi Arabia in...
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A replication-deficient gammaherpesvirus vaccine protects mice from lytic disease and reduces latency establishment
Gammaherpesviruses are oncogenic viruses that establish lifelong infections and are significant causes of morbidity and mortality. Vaccine strategies...
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Single-cell landscape of immunological responses in elderly patients with sepsis
Sepsis is a dysregulated host response to severe infections, and immune dysfunction plays a crucial role in its pathogenesis. Elderly patients, a...
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T cell independent antibody responses with class switch and memory using peptides anchored on liposomes
Vaccines generally require T lymphocytes for B-cell activation and immunoglobulin class switching in response to peptide or protein antigens. In the...
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An epidemiological analysis of severe imported malaria infections in Sri Lanka, after malaria elimination
BackgroundImported malaria continues to be reported in Sri Lanka after it was eliminated in 2012, and a few progress to life-threatening severe...
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Kinetics of pro- and anti-inflammatory spike-specific cellular immune responses in long-term care facility residents after COVID-19 mRNA primary and booster vaccination: a prospective longitudinal study in Japan
BackgroundThe magnitude and durability of cell-mediated immunity in older and severely frail individuals following coronavirus disease 2019...
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Influenza virus infection exacerbates gene expression related to neurocognitive dysfunction in brains of old mice
BackgroundAge > 65 years is a key risk factor for poor outcomes after human influenza infection. Specifically, in addition to respiratory disease,...
