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The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis
BackgroundRenal interstitial fibrosis (RIF) is a progressive, irreversible terminal kidney disease with a poor prognosis and high mortality....
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Understanding the experience, treatment preferences and goals of people living with chronic lymphocytic leukemia (CLL) in Australia
BackgroundListening to patient voices is critical, in terms of how people experience their condition as well as their treatment preferences. This...
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Circ_0000069 promotes the development of hepatocellular carcinoma by regulating CCL25
BackgroundHepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths globally, influenced by aberrant circRNA expression....
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An end-to-end workflow to study newly synthesized mRNA following rapid protein depletion in Saccharomyces cerevisiae
BackgroundGene transcription by RNA polymerase II is a fundamental process in eukaryotic cells. The precise regulation of transcription is necessary...
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Prevalence and antimicrobial susceptibility patterns of bacteria colonizing the external ocular surfaces of patients undergoing ocular surgeries at Bugando Medical Center in Mwanza, Tanzania
ObjectiveUnderstanding microbiota colonizing ocular surfaces is key to expedite antibiotic prophylactic options for ocular surgeries, and therefore,...
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Genetic constraint at single amino acid resolution in protein domains improves missense variant prioritisation and gene discovery
BackgroundOne of the major hurdles in clinical genetics is interpreting the clinical consequences associated with germline missense variants in...
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The black box of the relationship between breast cancer patients and accompanying patients: the accompanied patients’ point of view
BackgroundThe PAROLE-Onco program was introduced in the province of Quebec, Canada in 2019. It integrates accompanying patients (APs), i.e., people...
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Associations between modifiable risk factors and hepatocellular carcinoma: a trans-ancestry Mendelian randomization study
BackgroundPotentially modifiable risk factors for hepatocellular carcinoma (HCC) have been investigated in observational epidemiology studies in East...
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Systemic therapy and radiotherapy related complications and subsequent hospitalisation rates: a systematic review
BackgroundHospitalisation resulting from complications of systemic therapy and radiotherapy places a substantial burden on the patient, society, and...
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Influence of cryoablation versus operation on circulating lymphocyte subsets in patients with early-stage renal cell carcinoma
Immune response is known to play an important role in local tumor control especially in renal cell carcinoma (RCC), which is considered highly...
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Identification and bioinformatic characterization of a serum miRNA signature for early detection of laryngeal squamous cell carcinoma
BackgroundThe growing understanding of cancer biology and the establishment of new treatment modalities has not yielded the expected results in terms...
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miRNAs: possible regulators of toll like receptors and inflammatory tumor microenvironment in colorectal cancer
BackgroundColorectal cancer (CRC) is ranked as the third most commonly diagnosed cancer and the third cause of cancer related deaths. CRC is greatly...
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Efficacy and safety of direct oral anticoagulants versus warfarin in the treatment of cerebral venous sinus thrombosis
BackgroundGiven the evolving application and promising outcomes of direct oral anticoagulants (DOACs) in various thromboembolic conditions, we aimed...
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Advancing Understanding of Chemical Exposures and Maternal-child Health Through the U.S. Environmental Influences on Child Health Outcomes (ECHO) Program: A Sco** Review
Purpose of ReviewEnvironmental chemical exposures may disrupt child development, with long-lasting health impacts. To date, U.S. studies of early...
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Mortality rate and predictors of colorectal cancer patients in Ethiopia: a systematic review and meta-analysis
IntroductionThe incidence of colorectal cancer (CRC) has been increasing in Sub-Saharan countries, including Ethiopia. However, the real mortality...
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PET-CT-guided, symptom-based, patient-initiated surveillance versus clinical follow-up in head neck cancer patients (PETNECK2): study protocol for a multicentre feasibility study and non-inferiority, randomised, phase III trial
BackgroundApproximately 40% of treated head and neck cancer (HNC) patients develop recurrence. The risk of recurrence declines with time from...
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Novel drug resistance mechanisms and drug targets in BRAF-mutated peritoneal metastasis from colorectal cancer
BackgroundPatients with peritoneal metastasis from colorectal cancer (PM-CRC) have inferior prognosis and respond particularly poorly to...
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High positive predictive value of CNVs detected by clinical exome sequencing in suspected genetic diseases
BackgroundGenetic disorders often manifest as abnormal fetal or childhood development. Copy number variations (CNVs) represent a significant genetic...
