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Controlling Alzheimer’s disease by deep brain stimulation based on a data-driven cortical network model
This work aims to explore the control effect of DBS on Alzheimer's disease (AD) from a neurocomputational perspective. Firstly, a data-driven...
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Spinal cord lesion MRI and behavioral outcomes in a miniature pig model of spinal cord injury: exploring preclinical potential through an ad hoc comparison with human SCI
Study designprospective case series of Yucatan miniature pig spinal cord contusion injury model with comparison to human cases of spinal cord injury...
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A vagal–brainstem interoceptive circuit for cough-like defensive behaviors in mice
Coughing is a respiratory behavior that plays a crucial role in protecting the respiratory system. Here we show that the nucleus of the solitary...
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AI-based selection of individuals for supplemental MRI in population-based breast cancer screening: the randomized ScreenTrustMRI trial
Screening mammography reduces breast cancer mortality, but studies analyzing interval cancers diagnosed after negative screens have shown that many...
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Evaluation of AAV Capsids and Delivery Approaches for Hereditary Hemorrhagic Telangiectasia Gene Therapy
Nosebleeds and intracranial hemorrhage from brain arteriovenous malformations (bAVMs) are among the most devastating symptoms of patients with...
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A systematic review and meta-analysis of nonrelapse mortality after CAR T cell therapy
Although chimeric antigen receptor (CAR) T cell therapy represents a transformative immunotherapy, it is also associated with distinct toxicities...
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Safety of pulsed field ablation in more than 17,000 patients with atrial fibrillation in the MANIFEST-17K study
Pulsed field ablation (PFA) is an emerging technology for the treatment of atrial fibrillation (AF), for which pre-clinical and early-stage clinical...
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Microglia are dispensable for experience-dependent refinement of mouse visual circuitry
To test the hypothesized crucial role of microglia in the developmental refinement of neural circuitry, we depleted microglia from mice of both sexes...
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Sirtuin insights: bridging the gap between cellular processes and therapeutic applications
The greatest challenges that organisms face today are effective responses or detection of life-threatening environmental changes due to an obvious...
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Classifying Neuronal Cell Types Based on Shared Electrophysiological Information from Humans and Mice
The brain is an intricate system that controls a variety of functions. It consists of a vast number of cells that exhibit diverse characteristics. To...
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Ribosomal Protein Dynamics and Its Association with Actin Filaments and Local Translation in Axonal Growth Cones of Dorsal Root Ganglia Neurons
Local translation in growth cones plays a critical role in responses to extracellular stimuli, such as axon guidance cues. We previously showed that...
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The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back
Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...
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Simulated complexes formed from a set of postsynaptic proteins suggest a localised effect of a hypomorphic Shank mutation
BackgroundThe postsynaptic density is an elaborate protein network beneath the postsynaptic membrane involved in the molecular processes underlying...
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Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer’s disease
BackgroundWith the approval of disease-modifying treatments (DMTs) for early Alzheimer’s disease (AD), there is an increased need for efficient and...
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Frontal-striatal glucose metabolism and fatigue in patients with multiple sclerosis, long COVID, and COVID-19 recovered controls
This study compared brain glucose metabolism using FDG-PET in the caudate nucleus, putamen, globus pallidus, thalamus, and dorsolateral prefrontal...
