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Association of Crohn’s disease and ulcerative colitis with the risk of neurological diseases: a large-scale Mendelian randomization study
Observational studies suggested increased risks of Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS) in patients with...
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Quality of life for patients with advanced gastrointestinal cancer randomised to early specialised home-based palliative care: the ALLAN trial
BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a...
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FGFR3 drives Aβ-induced tau uptake
The amyloid cascade hypothesis suggests that amyloid beta (Aβ) contributes to initiating subsequent tau pathology in Alzheimer’s disease (AD)....
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KDM1A, a potent and selective target, for the treatment of DNMT3A-deficient non-small cell lung cancer
BackgroundDNMT3A is a crucial epigenetic regulation enzyme. However, due to its heterogeneous nature and frequent mutation in various cancers, the...
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Cancer risk in individuals with polydactyly: a Swedish population-based cohort study
BackgroundPolydactyly is a feature of several cancer predisposition syndromes (CPS), however, cancer risk in individuals with polydactyly is largely...
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Cancer fatalism, social media informational awareness, and education
ObjectiveUnderstand if cancer fatalism among adult social media users in the United States is linked to social media informational awareness and if...
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The limits of fair medical imaging AI in real-world generalization
As artificial intelligence (AI) rapidly approaches human-level performance in medical imaging, it is crucial that it does not exacerbate or propagate...
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Cabozantinib and nivolumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
Supplementation with CBM588, a bifidogenic live bacterial product, has been associated with improved clinical outcomes in persons with metastatic...
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Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis
Chronic kidney disease (CKD) poses a significant global health dilemma, emerging from complex causes. Although our prior research has indicated that...
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Exposure to second-hand smoke and breast cancer risk in non-smoking women: a comprehensive systematic review and meta-analysis
Through the use of an innovative method to identify original publications, we conducted a meta-analysis of all epidemiological studies evaluating the...
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Aging- and alcohol-associated spatial transcriptomic signature in mouse acute pancreatitis reveals heterogeneity of inflammation and potential pathogenic factors
AbstractThe rapidly aging population is consuming more alcohol, leading to increased alcohol-associated acute pancreatitis (AAP) with high mortality....
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Molecular targets in bone cancer pain: a systematic review of inflammatory cytokines
Bone cancer pain (BCP) profoundly impacts patient’s quality of life, demanding more effective pain management strategies. The aim of this systematic...
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Synergy of retinoic acid and BH3 mimetics in MYC(N)-driven embryonal nervous system tumours
BackgroundCertain paediatric nervous system malignancies have dismal prognoses. Retinoic acid (RA) is used in neuroblastoma treatment, and...
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Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of...
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L-theanine alleviates myocardial ischemia/reperfusion injury by suppressing oxidative stress and apoptosis through activation of the JAK2/STAT3 pathway in mice
BackgroundL-theanine is a unique non-protein amino acid in tea that is widely used as a safe food additive. We investigated the cardioprotective...
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Acupoint catgut embedding attenuates oxidative stress and cognitive impairment in chronic cerebral ischemia by inhibiting the Ang II/AT1R/NOX axis
Chronic cerebral ischemia (CCI) is a common neurological disorder, characterized by progressive cognitive impairment. Acupoint catgut embedding (ACE)...
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Development of autonomic heart rate modulations during childhood and adolescence
Autonomic control of heart rate is well known in adult subjects, but limited data are available on the development of the heart rate control during...
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AAV gene therapy for hereditary spastic paraplegia type 50: a phase 1 trial in a single patient
There are more than 10,000 individual rare diseases and most are without therapy. Personalized genetic therapy represents one promising approach for...
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Finotonlimab with chemotherapy in recurrent or metastatic head and neck cancer: a randomized phase 3 trial
Immunotherapy combined with chemotherapy regimen has been shown to be effective in recurrent or metastatic (R/M) head and neck squamous cell...
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