Search
Search Results
-
Monoclonal Antibody Generation Using Single B Cell Screening for Treating Infectious Diseases
The screening of antigen-specific B cells has been pivotal for biotherapeutic development for over four decades. Conventional antibody discovery...
-
Activation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ
The hypoxia-inducible factor-1α (HIF-1α) pathway coordinates skeletal bone homeostasis and endocrine functions. Activation of the HIF-1α pathway...
-
Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia
Angiotensin II (AngII) induces the contraction and proliferation of vascular smooth muscle cells (VSMCs). AngII activates phospholipase C-β (PLC-β),...
-
From inflammation to bone formation: the intricate role of neutrophils in skeletal muscle injury and traumatic heterotopic ossification
Neutrophils are emerging as an important player in skeletal muscle injury and repair. Neutrophils accumulate in injured tissue, thus releasing...
-
PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways
The development of chemoresistance is a major challenge in the treatment of several types of cancers in clinical settings. Stemness and...
-
Continuous neural control of a bionic limb restores biomimetic gait after amputation
For centuries scientists and technologists have sought artificial leg replacements that fully capture the versatility of their intact biological...
-
Digital innovation for cancer risk assessment allows large-scale service redevelopment of regional cancer genetics service delivery
Family-history assessment can identify individuals above population-risk for cancer to enable targeted Screening, Prevention and Early Detection...
-
A novel heterozygous TMEM63A variant in a familial case with early onset nystagmus, severe hypomyelination, and a favorable adult prognosis
Heterozygous transmembrane protein 63A ( TMEM63A ) variants cause transient infantile hypomyelinating leukodystrophy-19, which features remarkable...
-
Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions
Calcific aortic valve disease (CAVD) is becoming an increasingly important global medical problem, but effective pharmacological treatments are...
-
MAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Develo** mouse...
-
Disparities in air pollution attributable mortality in the US population by race/ethnicity and sociodemographic factors
There are large differences in premature mortality in the USA by race/ethnicity, education, rurality and social vulnerability index groups. Using...
-
Investigating druggable kinases for targeted therapy in retinoblastoma
Retinoblastoma (RB) is a childhood retinal neoplasm and commonly treated with cytotoxic chemotherapeutic agents. However, these therapeutic...
-
Patient-derived tumor organoids: a new avenue for preclinical research and precision medicine in oncology
Over the past decade, the emergence of patient-derived tumor organoids (PDTOs) has broadened the repertoire of preclinical models and progressively...
-
YAP1 inhibits the senescence of alveolar epithelial cells by targeting Prdx3 to alleviate pulmonary fibrosis
The senescence of alveolar type II (AT2) cells impedes self-repair of the lung epithelium and contributes to lung injury in the setting of idiopathic...
-
Development of a novel testis-on-a-chip that demonstrates reciprocal crosstalk between Sertoli and Leydig cells in testicular tissue
The reciprocal crosstalk between testicular Sertoli and Leydig cells plays a vital role in supporting germ cell development and maintaining...
-
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders
Proinflammatory cytokines and chemokines play a crucial role in regulating the inflammatory response, which is essential for the proper functioning...
-
Enhancing in situ cancer vaccines using delivery technologies
In situ cancer vaccination refers to any approach that exploits tumour antigens available at a tumour site to induce tumour-specific adaptive immune...
-
PHGDH: a novel therapeutic target in cancer
Serine is a key contributor to the generation of one-carbon units for DNA synthesis during cellular proliferation. In addition, it plays a crucial...
-
Genome-resolved metagenomics: a game changer for microbiome medicine
Recent substantial evidence implicating commensal bacteria in human diseases has given rise to a new domain in biomedical research: microbiome...
