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Predictive accuracy of genetic variants for eye color in a Kazakh population using the IrisPlex system
ObjectiveThis study assesses the accuracy of the IrisPlex system, a genetic eye color prediction tool for forensic analysis, in the Kazakh...
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Impact of a rash management guide in patients receiving apalutamide for high-risk localized prostate cancer in the Apa-RP study
Background/objectivesBased on the SPARTAN and TITAN studies, apalutamide is approved for patients with nonmetastatic castration-resistant and...
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Urinary microbiome dysbiosis is associated with an inflammatory environment and perturbed fatty acids metabolism in the pathogenesis of bladder cancer
BackgroundBladder cancer is a common malignancy with high recurrence rate. Early diagnosis and recurrence surveillance are pivotal to patients’...
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Recent advances in albumin nanoparticle-based cancer therapies
BackgroundNanotechnology is increasingly utilized in treating complex and challenging diseases, notably cancer. Among the emerging strategies,...
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Efficient Cardiovascular Parameters Estimation for Fluid-Structure Simulations Using Gappy Proper Orthogonal Decomposition
As full-scale detailed hemodynamic simulations of the entire vasculature are not feasible, numerical analysis should be focused on specific regions...
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Dissecting the sequential evolution of a selfish mitochondrial genome in Caenorhabditis elegans
Mitochondrial genomes exist in a nested hierarchy of populations where mitochondrial variants are subject to genetic drift and selection at each...
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Equity in action: The Diagnostic Working Group of The Undiagnosed Diseases Network International
Rare diseases are recognized as a global public health priority. A timely and accurate diagnosis is a critical enabler for precise and personalized...
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Differentiation of glioma and solitary brain metastasis: a multi-parameter magnetic resonance imaging study using histogram analysis
BackgroundDifferentiation of glioma and solitary brain metastasis (SBM), which requires biopsy or multi-disciplinary diagnosis, remains sophisticated...
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Fabrication of Highly Sensitive and Selective Nitrite Colorimetric Sensor Based on the Enhanced Peroxidase Mimetic Activity of Using Acetic Acid Capped Zinc Oxide Nanosheets
Nitrite ions (NO 2 - ), as one of the leading type-A inorganic-anion, showing significant-effects in the aquatic environment and also to humans health....
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Cancer cell extravasation requires iplectin-mediated delivery of MT1-MMP at invadopodia
BackgroundInvadopodia facilitate cancer cell extravasation, but the molecular mechanism whereby invadopodia-specific proteases such as MT1-MMP are...
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Classification of anticancer drugs: an update with FDA- and EMA-approved drugs
Anticancer systemic therapy comprises a complex and growing group of drugs. Some of the new agents with novel mechanisms of action that have appeared...
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Metabolic adaptations in prostate cancer
Prostate cancer is one of the most commonly diagnosed cancers in men and is a major cause of cancer-related deaths worldwide. Among the molecular...
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Epigenetic recording of stimulation history reveals BLIMP1–BACH2 balance in determining memory B cell fate upon recall challenge
Memory B cells (MBCs) differentiate into plasma cells (PCs) or germinal centers (GCs) upon antigen recall. How this decision is programmed is not...
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Metronomic chemotherapy plus anti-PD-1 in metastatic breast cancer: a Bayesian adaptive randomized phase 2 trial
It remains unclear whether metronomic chemotherapy is superior to conventional chemotherapy when combined with immune checkpoint blockade. Here we...
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Somatic RIT1 delins in arteriovenous malformations hyperactivate RAS-MAPK signaling amenable to MEK inhibition
Arteriovenous malformations (AVM) are benign vascular anomalies prone to pain, bleeding, and progressive growth. AVM are mainly caused by mosaic...
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Formulation and in vitro/in vivo characterization of a fixed-dose combination tablet of dapagliflozin and rosuvastatin
PurposeThis study aimed to develop a single fixed-dose combination (FDC) tablet containing dapagliflozin and rosuvastatin, given the increasing use...
