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Formulation, Optimization and In-Vivo Characterization of Thermosensitive In-Situ Nasal Gel Loaded with Bacoside a for Treatment of Epilepsy
The intranasal route has demonstrated superior systemic bioavailability due to its extensive surface area, the porous nature of the endothelial...
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Ginkgolide C attenuated Western diet-induced non-alcoholic fatty liver disease via increasing AMPK activation
BackgroundNon-alcoholic steatohepatitis (NASH) is a metabolic dysregulation-related disorder that is generally characterized by lipid metabolism...
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Graph features based classification of bronchial and pleural rub sound signals: the potential of complex network unwrapped
The study presents a novel technique for lung auscultation based on graph theory, emphasizing the potential of graph parameters in distinguishing...
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Validation of the constitution in Chinese medicine questionnaires with the newly developed blood-vacuity category: a rare Taiwanese case study
The concept of body constitution (BC) is a core notion in traditional Chinese medicine, used in diagnosis, treatment, and prevention; however, there...
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Phyto-chemical, analytical evaluation and biological attributes of rare medicinal species of flowering shrub Bauhinia racemosa L.
The current investigation compared the efficacy of an ethanol extract of B. racemosa L. leaf against standard bacterial and fungal cultures....
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Left ventricle diastolic vortex ring characterization in ischemic cardiomyopathy: insight into atrio-ventricular interplay
Diastolic vortex ring (VR) plays a key role in the blood-pum** function exerted by the left ventricle (LV), with altered VR structures being...
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The Molecular Mechanism of Radix Paeoniae Rubra.-Cortex Moutan. Herb Pair in the Treatment of Atherosclerosis: A Work Based on Network Pharmacology and In Vitro Experiments
Radix Paeoniae Rubra. (Chishao, RPR) and Cortex Moutan. (Mudanpi, CM) are a pair of traditional Chinese medicines that play an important role in the...
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Characterizing lipid constituents of B. moojeni snake venom: a comparative approach for chemical and biological investigations
Snake venoms are complex mixtures majorly composed of proteins with well-studied biological effects. However, the exploration of non-protein...
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Enhancing in situ cancer vaccines using delivery technologies
In situ cancer vaccination refers to any approach that exploits tumour antigens available at a tumour site to induce tumour-specific adaptive immune...
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External Evaluation of Population Pharmacokinetic Models of Piperacillin in Preterm and Term Patients from Neonatal Intensive Care
Background and ObjectivesPiperacillin/tazobactam is extensively used off-label to treat late-onset neonatal sepsis, but safety and pharmacokinetic...
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Amorfrutin B Compromises Hypoxia/Ischemia-induced Activation of Human Microglia in a PPARγ-dependent Manner: Effects on Inflammation, Proliferation Potential, and Mitochondrial Status
Amorfrutin B is a selective PPARγ modulator that we demonstrated to be a promising neuroprotective compound in cellular models of stroke and...
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Deficiency of Secreted Phosphoprotein 1 Alleviates Hyperoxia-induced Bronchopulmonary Dysplasia in Neonatal Mice
Bronchopulmonary dysplasia (BPD) is a common chronic lung disorder characterized by impaired proximal airway and bronchoalveolar development in...
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Dissecting the antidepressant effect of troxerutin: modulation of neuroinflammatory and oxidative stress biomarkers in lipopolysaccharide-treated mice
The role of neuroinflammation in the pathogenesis of depression has prompted the search for new antidepressants. Troxerutin, a bioflavonoid with...
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Mediation of circ_0007142 on miR-128-3p/S100A14 pathway to stimulate the progression of cervical cancer
A previous study has confirmed the upregulation of circ_0007142 expression in CC. Here, we aimed to investigate the effect and mechanism of...
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Autophagy Regulation Attenuates Neuroinflammation and Cognitive Decline in an Alzheimer's Disease Mouse Model with Chronic Cerebral Hypoperfusion
This study investigates the role of autophagy regulation in modulating neuroinflammation and cognitive function in an Alzheimer's disease (AD) mouse...
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Primary Creep Characterization in Porcine Lumbar Spine Subject to Repeated Loading
Low back pain (LBP) is a common medical condition worldwide, though the etiology of injuries causing most LBP is unknown. Flexion and repeated...
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An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer’s disease: targeting molecular approach Nrf2, NF-κB, and CREB
Alzheimer’s disease (AD) is a most prevalent neurologic disorder characterized by cognitive dysfunction, amyloid-β (Aβ) protein accumulation, and...
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Instability in Computational Models of Vascular Smooth Muscle Cell Contraction
PurposeThrough their contractile and synthetic capacity, vascular smooth muscle cells (VSMCs) can regulate the stiffness and resistance of the...
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The Role of Excitotoxicity, Oxidative Stress and Bioenergetics Disruption in the Neuropathology of Nonketotic Hyperglycinemia
Nonketotic hyperglycinemia (NKH) is an inherited disorder of amino acid metabolism biochemically characterized by the accumulation of glycine (Gly)...
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Role of Charge Heterogeneity on Physical Stability of Monoclonal Antibody Biotherapeutic Products
PurposeChemical modifications in monoclonal antibodies can change hydrophobicity, charge heterogeneity as well as conformation, which eventually can...
