432 Result(s)

Article

Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets

Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate mechanisms underlying I/R injury...

Meng Zhang, Qian Liu, Hui Meng, Hongxia Duan… in Signal Transduction and Targeted Therapy (2024)

Article

A real-world study of the effectiveness and safety of apatinib-based regimens in metastatic triple-negative breast cancer

This investigation sought to examine the efficacy and safety of low-dose apatinib used alongside chemotherapy in the clinical management of patients with metastatic triple-negative breast cancer (TNBC) within ...

Weiwei Huang, Chenxi Wang, Yangkun Shen, Qi Chen, Zhijian Huang, Jian Liu… in BMC Cancer (2024)

Article

Strategies for the development and approval of COVID-19 vaccines and therapeutics in the post-pandemic period

The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in significant casualties and put immense strain on public health systems worldwide, leading to economic recession and so...

Danyi Ao, Xuemei He, Jian Liu, Li Xu in Signal Transduction and Targeted Therapy (2023)

Article

A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma

Circular RNAs (circRNAs) are a class of noncoding RNAs that are involved in the progression of many human cancers. The precise gene locus and the roles of circular RNA from Fibronectin type III domain containi...

Congya Li, Linchao Ding, Xuyao Wang, Peng Shu, Xuchao Shi… in Cancer Cell International (2023)

Article

Antigen-induced chimeric antigen receptor multimerization amplifies on-tumor cytotoxicity

Ligand-induced receptor dimerization or oligomerization is a widespread mechanism for ensuring communication specificity, safeguarding receptor activation, and facilitating amplification of signal transduction...

Yan Sun, **u-Na Yang, Shuang-Shuang Yang… in Signal Transduction and Targeted Therapy (2023)

Article

Retraction Note: 8-bromo-7-methoxychrysin suppress stemness of SMMC-7721 cells induced by co-culture of liver cancer stem-like cells with hepatic stellate cells

Qi Wen, Chang Xu, Jie Zhou, Nuo-Min Liu, Ying-Hong Cui, Mei-Fang Quan… in BMC Cancer (2023)

Article

Cancer-associated fibroblasts induce sorafenib resistance of hepatocellular carcinoma cells through CXCL12/FOLR1

Due to the high drug resistance of hepatocellular carcinoma (HCC), sorafenib has limited efficacy in the treatment of advanced HCC. Cancer-associated fibroblasts (CAFs) play an important regulatory role in the...

Jiali Zhao, En Lin, Zirui Bai, Yingbin Jia, Bo Wang, Yihua Dai, Wenfeng Zhuo… in BMC Cancer (2023)

Article

Clinical and DCE-CT signs in predicting microvascular invasion in cHCC-ICC

To predict the microvascular invasion (MVI) in patients with cHCC-ICC.

Zhong-Jian Liao, Lun Lu, Yi-** Liu, Geng-geng Qin, Cun-geng Fan… in Cancer Imaging (2023)

Article

Prognostic value of platelet distribution width to lymphocyte ratio in patients with hepatocellular carcinoma following hepatectomy

Platelet distribution width (PDW), but not platelet count, was found to more comprehensively reflect platelet activity. The present study, thus, aimed to evaluate the prognostic value of PDW to lymphocyte rati...

Zhi-Han Zhong, Lei Liang, Tian-Wei Fu, Mu-Gen Dai, Jian Cheng, Si-Yu Liu… in BMC Cancer (2023)

Article

Correction: Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma

Qian Zhu, Ai-Lin Zhong, Hao Hu, **g-**g Zhao… in Journal of Hematology & Oncology (2023)

Article

SARS-CoV-2 spike-specific T_FH cells exhibit unique responses in infected and vaccinated individuals

Long-term humoral immunity to SARS-CoV-2 is essential for preventing reinfection. The production of neutralizing antibody (nAb) and B cell differentiation are tightly regulated by T follicular help (T_FH) cells. H...

Rongzhang He, **ngyu Zheng, Jian Zhang, Bo Liu… in Signal Transduction and Targeted Therapy (2023)

Article

Long intergenic non-coding RNA DIO3OS promotes osteosarcoma metastasis via activation of the TGF-β signaling pathway: a potential diagnostic and immunotherapeutic target for osteosarcoma

The aim of this study was to determine the underlying potential mechanisms and function of DIO3OS, a lincRNA in osteosarcoma and clarify that DIO3OS can be used as a potential diagnostic biomarker and immunoth...

**ghong Yuan, **gyu Jia, Tianlong Wu, Zhi Du, Qi Chen… in Cancer Cell International (2023)

Article

DSCC1 interacts with HSP90AB1 and promotes the progression of lung adenocarcinoma via regulating ER stress

Lung cancer is a leading cause of cancer-related deaths, and the most common type is lung adenocarcinoma (LUAD). LUAD is frequently diagnosed in people who never smoked, patients are always diagnosed at advanc...

Xu Lin, Ye-han Liu, Huan-qi Zhang, Lin-wen Wu, Qi Li, Jun Deng… in Cancer Cell International (2023)

Article

Risk of temporal lobe necrosis between proton beam and volumetric modulated arc therapies in patients with different head and neck cancers

To investigate the frequency of temporal lobe necrosis (TLN) soon after radiotherapy (RT) and identify differences among patients with various types of head and neck cancer (HNC) and between different RT methods.

Chi-Hung Liu, Chien-Yu Lin, Bing-Shen Huang, Yi-Chia Wei… in Radiation Oncology (2023)

Article

CT041 CAR T cell therapy for Claudin18.2-positive metastatic pancreatic cancer

Pancreatic cancer lacks effective therapy. Here, we reported two metastatic pancreatic cancer patients administrated with Claudin 18.2 (CLDN 18.2) CART therapy after the failure of standard therapy (NCT0458147...

Changsong Qi, Tong **e, Jun Zhou, **cheng Wang… in Journal of Hematology & Oncology (2023)

Article

Real-world evidence of osimertinib in Chinese patients with EGFR T790M-positive non-small cell lung cancer: a subgroup analysis from ASTRIS study

ASTRIS study aimed the largest to evaluate the effectiveness and safety of second- or higher-line osimertinib in patients with advanced/metastatic epidermal growth factor receptor (EGFR) T790M mutation-positive n...

Qing Zhou, He-Long Zhang, Li-Yan Jiang… in Journal of Cancer Research and Clinical On… (2023)

Article

Preoperative sarcopenia combined with prognostic nutritional index predicts long-term prognosis of radical gastrectomy with advanced gastric cancer: a comprehensive analysis of two-center study

This study aims to investigate the predictive value of the combined index smni(skeletal muscle index (SMI)-prognostic nutrition index(PNI)) for the postoperative survival of patients with advanced gastric canc...

Yubo Han, Ju Wu, Rui Ji, Hao Tan, Simiao Tian, Jiajun Yin, Jian Xu, ** Chen… in BMC Cancer (2023)

Article

High-density lipoprotein regulates angiogenesis by long non-coding RNA HDRACA

Normal high-density lipoprotein (nHDL) can induce angiogenesis in healthy individuals. However, HDL from patients with coronary artery disease undergoes various modifications, becomes dysfunctional (dHDL), and...

Zhi-Wei Mo, Yue-Ming Peng, Yi-**n Zhang, Yan Li… in Signal Transduction and Targeted Therapy (2023)

Article

Necroptosis-related LncRNAs in skin cutaneous melanoma: evaluating prognosis, predicting immunity, and guiding therapy

An increasing amount of research has speculated that necroptosis could be a therapeutic strategy for treating cancer. However, understanding the prognostic value of the necroptosis-related long non-coding RNAs...

Jianlan Liu, Binlin Luo, Pengpeng Zhang, Keyu Jiang, Zuoqiong Hou… in BMC Cancer (2023)

Article

ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/β-catenin pathway

Circular RNAs (circRNAs) circularized by back-splicing of pre-mRNA are widely expressed and affected the proliferation, invasion and metastasis of bladder cancer (BCa). However, the mechanism underlying circRN...

Yuanlong Li, Yao Kong, Mingjie An… in Journal of Experimental & Clinical Cancer … (2023)