75 Result(s)

Article

Endogenous pore-forming protein complex targets acidic glycosphingolipids in lipid rafts to initiate endolysosome regulation

Bacterial pore-forming toxin aerolysin-like proteins (ALPs) are widely distributed in animals and plants. However, functional studies on these ALPs remain in their infancy. βγ-CAT is the first example of a sec...

**ao-Long Guo, Ling-Zhen Liu, Qi-Quan Wang, **-Yang Liang… in Communications Biology (2019)

Article

RpfC regulates the expression of the key regulator hrpX of the hrp/T3SS system in Xanthomonas campestris pv. campestris

The Gram-negative phytopathogenic bacterium Xanthomonas campestris pv. campestris recruits the hrp/T3SS system to inject pathogenicity effector proteins into host cells and uses the rpf/DSF cell-cell signaling sy...

Bo-Le Jiang, Guo-Feng Jiang, Wei Liu, Li-Chao Yang, Li-Yan Yang… in BMC Microbiology (2018)

Article

CD45⁺CD33^lowCD11b^dim myeloid-derived suppressor cells suppress CD8⁺ T cell activity via the IL-6/IL-8-arginase I axis in human gastric cancer

Myeloid-derived suppressor cells (MDSCs) are a prominent component of the pro-tumoral response. The phenotype of and mechanisms used by MDSCs is heterogeneous and requires more precise characterization in gast...

Fang-yuan Mao, Yong-liang Zhao, Yi-pin Lv, Yong-sheng Teng… in Cell Death & Disease (2018)

Article

The transcription factor Zfp90 regulates the self-renewal and differentiation of hematopoietic stem cells

Hematopoietic stem cells (HSCs) can give rise to all blood cells that are essential to defend against pathogen invasion. The defective capability of HSC self-renewal is linked to many serious diseases, such as...

Ting Liu, Wei-xia Kong, **ao-yi Tang, Man Xu, Qing-han Wang… in Cell Death & Disease (2018)

Article

Helicobacter pylori-induced IL-33 modulates mast cell responses, benefits bacterial growth, and contributes to gastritis

Interleukin (IL)-induced inflammatory responses are critical for the pathogenesis of Helicobacter pylori (H. pylori)-induced gastritis. IL-33 represents a recently discovered proinflammatory cytokine involved in ...

Yi-pin Lv, Yong-sheng Teng, Fang-yuan Mao, Liu-sheng Peng… in Cell Death & Disease (2018)

Article

Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin

The incidence and mortality of intrahepatic cholangiocarcinoma (ICC) are increasing worldwide in recent decades. Osteopontin (OPN) plays an important role in cancer metastasis, but its functional mechanism in ...

Yan Zheng, Chuang Zhou, **n-**n Yu, Chao Wu, Hu-Liang Jia… in Cell Death & Disease (2018)

Article

Pathological hydrogen peroxide triggers the fibrillization of wild-type SOD1 via sulfenic acid modification of Cys-111

Amyotrophic lateral sclerosis (ALS) involves the abnormal posttranslational modifications and fibrillization of copper, zinc superoxide dismutase (SOD1) and TDP-43. However, how SOD1-catalyzed reaction product...

Wen-Chang Xu, **-Zhao Liang, Cheng Li, Zhi-**n He, Han-Ye Yuan… in Cell Death & Disease (2018)

Article

Correction: Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation

Nature Cell Biology 19, 808–819 (2017); published online 12 June 2017; corrected after print 13 November 2017. In the original version of this Article, the procedure for assessing the ubiquitylation assays by ...

Yong-Jian Wang, Yan Bian, Jie Luo, Ming Lu, Ying **ong, Shu-Yuan Guo… in Nature Cell Biology (2017)

Article

Cezanne predicts progression and adjuvant TACE response in hepatocellular carcinoma

We have previously reported that Cezanne could be a prognostic biomarker for survival in hepatocellular carcinoma (HCC) patients. However, the role of Cezanne genes in HCC cells and its response to postoperati...

Jia-hong Wang, ** Zhong, Yong-fa Zhang, … in Cell Death & Disease (2017)

Article

Increased tumor-infiltrating CD45RA⁻CCR7⁻ regulatory T-cell subset with immunosuppressive properties foster gastric cancer progress

Regulatory T cells (Tregs) are major components of tumor-infiltrating immune cells with potent immunosuppressive properties in gastric cancer (GC) microenvironment. However, different subsets of the Tregs and ...

Fang-yuan Mao, Hui Kong, Yong-liang Zhao, Liu-sheng Peng… in Cell Death & Disease (2017)

Article

Long noncoding RNA XIST expedites metastasis and modulates epithelial–mesenchymal transition in colorectal cancer

Tumor progression and metastasis is the main cause of death in colorectal cancer (CRC). Long noncoding RNAs (lncRNAs) are critical regulators in various diseases including human cancer. In this study, we found...

Dong-liang Chen, Le-zong Chen, Yun-xin Lu, Dong-sheng Zhang… in Cell Death & Disease (2017)

Article

5-methylcytosine promotes mRNA export — NSUN2 as the methyltransferase and ALYREF as an m⁵C reader

5-methylcytosine (m⁵C) is a post-transcriptional RNA modification identified in both stable and highly abundant tRNAs and rRNAs, and in mRNAs. However, its regulatory role in mRNA metabolism is still largely unkn...

**n Yang, Ying Yang, Bao-Fa Sun, Yu-Sheng Chen, Jia-Wei Xu, Wei-Yi Lai… in Cell Research (2017)

Article

Cytoplasmic m⁶A reader YTHDF3 promotes mRNA translation

Ang Li, Yu-Sheng Chen, **ao-Li **, **n Yang, Wen **ao, Ying Yang… in Cell Research (2017)

Article

The protein level and transcription activity of activating transcription factor 1 is regulated by prolyl isomerase Pin1 in nasopharyngeal carcinoma progression

The function of activating transcription factor 1 (ATF1) and the mechanism about why ATF1 was over-phosphorylated in nasopharyngeal carcinoma (NPC) progression is completely undiscovered. In this study, a seri...

Guo-Liang Huang, Dan Liao, Hua Chen, Yan Lu, Liyong Chen, Huahui Li… in Cell Death & Disease (2016)

Article

EZH2 mediates lidamycin-induced cellular senescence through regulating p21 expression in human colon cancer cells

Lidamycin (LDM) is a novel member of the enediyne antibiotics identified in China with potent antitumor activity. However, it remains unclear whether LDM has potential molecular targets that may affect its ant...

Ming-Quan Sha, **ao-Li Zhao, Liang Li, Li-Hui Li, Yi Li… in Cell Death & Disease (2016)

Article

Genome editing with CRISPR/Cas9 in postnatal mice corrects PRKAG2 cardiac syndrome

PRKAG2 cardiac syndrome is an autosomal dominant inherited disease resulted from mutations in the PRKAG2 gene that encodes γ2 regulatory subunit of AMP-activated protein kinase. Affected patients usually develop ...

Chang **e, Ya-** Zhang, Lu Song, Jie Luo, Wei Qi, Jialu Hu, Danbo Lu… in Cell Research (2016)

Article

Melatonin enhances sensitivity to fluorouracil in oesophageal squamous cell carcinoma through inhibition of Erk and Akt pathway

Oesophageal squamous cell carcinoma (ESCC) is the sixth most common cause of cancer-associated death in the world and novel therapeutic alternatives are urgently warranted. In this study, we investigated the a...

Yun-**n Lu, Dong-Liang Chen, De-Shen Wang, Le-Zong Chen, Hai-Yu Mo… in Cell Death & Disease (2016)