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  1. Article

    Open Access

    The effect of liraglutide on nonalcoholic fatty liver disease in type 2 diabetes mellitus

    The objective is to investigate the effects of liraglutide on nonalcoholic fatty liver disease in type 2 diabetes mellitus.

    Xueyang Zhang, Ran Bai, Yong Jia in International Journal of Diabetes in Devel… (2020)

  2. Article

    Estimation of reproduction numbers of COVID-19 in typical countries and epidemic trends under different prevention and control scenarios

    The coronavirus disease 2019 (COVID-19) has become a life-threatening pandemic. The epidemic trends in different countries vary considerably due to different policy-making and resources mobilization. We calcul...

    Chen Xu, Yinqiao Dong, **aoyue Yu, Huwen Wang, Lhakpa Tsamlag in Frontiers of Medicine (2020)

  3. Article

    Open Access

    Hydrocortisone to treat early bronchopulmonary dysplasia in very preterm infants: study protocol for a randomized controlled trial

    Bronchopulmonary dysplasia (BPD) is still a common complication in very premature infants. At present, there is no effective treatment for BPD. Glucocorticoids are drugs commonly used to prevent or treat BPD b...

    Yuan He, Yong Zhang, Shuqiang Gao, **aoling Wang, Na He, Deshuang Zhang in Trials (2020)

  4. Article

    Exploring an Integrative Therapy for Treating COVID-19: A Randomized Controlled Trial

    To develop a new Chinese medicine (CM)-based drug and to evaluate its safety and effect for suppressing acute respiratory distress syndrome (ARDS) in COVID-19 patients.

    Jia-bo Wang, Zhong-xia Wang, **g **g in Chinese Journal of Integrative Medicine (2020)

  5. Article

    Open Access

    Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance

    Chronic pain and sleep disturbance are highly comorbid disorders, which leads to barriers to treatment and significant healthcare costs. Understanding the underlying genetic and neural mechanisms of the interp...

    Jie Sun, Wei Yan, **ng-Nan Zhang, **ao Lin, Hui Li in Translational Psychiatry (2020)

  6. Article

    Phase- and epidemic region-adjusted estimation of the number of coronavirus disease 2019 cases in China

    The outbreak of the coronavirus disease 2019 was first reported in Wuhan in December 2019 and gradually spread to other areas in China. After implementation of prevention and control measures, the estimation o...

    Ruijie Chang, Huwen Wang, Shuxian Zhang, Zezhou Wang, Yinqiao Dong in Frontiers of Medicine (2020)

  7. Article

    Open Access

    Predictive value of random blood glucose versus fasting blood glucose on in-hospital adverse events in patients with ST-segment elevation acute myocardial infarction

    We aim to find out the relationship between random blood glucose (RBG), fasting blood glucose (FBG) and in-hospital adverse events in ST-segment elevation acute myocardial infarction (STEMI) patients. We evalu...

    Yuhan Qin, Gaoliang Yan, Yong Qiao, Dong Wang, Erfei Luo in BMC Cardiovascular Disorders (2020)

  8. Article

    Open Access

    Burden of male hardcore smokers and its characteristics among those eligible for lung cancer screening

    There are few data available about hardcore smokers and their behavioral characteristics among the lung cancer screening (LCS) population. The study investigated the burden of hardcore smokers within the LCS p...

    Dong Won Park, Ji-Yun Jang, Tai Sun Park, Hyun Lee, Ji-Yong Moon in BMC Public Health (2020)

  9. Article

    Open Access

    The depression GWAS risk allele predicts smaller cerebellar gray matter volume and reduced SIRT1 mRNA expression in Chinese population

    Major depressive disorder (MDD) is recognized as a primary cause of disability worldwide, and effective management of this illness has been a great challenge. While genetic component is supposed to play pivota...

    Weipeng Liu, Hao Yan, Danyang Zhou, **n Cai, Yuyanan Zhang in Translational Psychiatry (2019)

  10. Article

    Open Access

    Safety and efficacy of PG102P for the control of pruritus in patients undergoing hemodialysis (SNUG trial): study protocol for a randomized controlled trial

    Pruritus in patients undergoing hemodialysis is a highly prevalent complication that affects quality of life. Several medications are currently used for the treatment of uremic pruritus, but these are not sati...

    Yong Chul Kim, Jae Yoon Park, Sohee Oh, Jang-Hee Cho, Jae Hyun Chang in Trials (2019)

  11. Article

    Open Access

    Genetically engineered T cells for cancer immunotherapy

    T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy, by relying on this basic re...

    Dan Li, Xue Li, Wei-Lin Zhou, Yong Huang in Signal Transduction and Targeted Therapy (2019)

  12. Article

    Open Access

    Cervicogenic headache treated by acupuncture based on ** theory: study protocol for a randomized controlled trial

    Numerous randomized trials involving acupuncture treatment for cervicogenic headache (CEH) have been conducted in recent years, but the evidence for its effectiveness is not clear. Hence, we designed a randomi...

    Youkang Dong, Taipin Guo, Lei Xu, Chunlin Wang, Guanfen Wen, Zhiyong Zhao in Trials (2019)

  13. Article

    Open Access

    Comparison of effectiveness between warm acupuncture with local-distal points combination and local distribution points combination in breast cancer-related lymphedema patients: a study protocol for a multicenter, randomized, controlled clinical trial

    Lymphedema is the most common complication after breast cancer treatment, but management of lymphedema remains a clinical challenge. Several studies have reported the beneficial effect of acupuncture for treat...

    Chien-Hung Yeh, Tian Yi Zhao, Mei Dan Zhao, Yue Wu, Yong Ming Guo, Zhan Yu Pan in Trials (2019)

  14. Article

    Open Access

    Fimasartan versus perindopril with and without diuretics in the treatment of elderly patients with essential hypertension (Fimasartan in the Senior Subjects (FITNESS)): study protocol for a randomized controlled trial

    Hypertension is an important risk factor for cardiovascular disease, even in the elderly. Fimasartan is a new non-peptide angiotensin II receptor blocker with a selective type I receptor blocking effect. The o...

    Min-gu Kang, Kwang-il Kim, Sang Hyun Ihm, Moo-Yong Rhee, Il Suk Sohn in Trials (2019)

  15. Article

    Open Access

    The cerebral mechanism of acupuncture for treating knee osteoarthritis: study protocol for a randomized controlled trial

    Acupuncture is safe and effective for reducing the symptoms of knee osteoarthritis (KOA), but the underlying mechanisms of acupuncture for treating KOA are not fully understood.

    **g Guo, Yang Chen, Zhengjie Li, Shirui Cheng, Chenjian Tang, **aohui Dong in Trials (2019)

  16. Article

    Open Access

    Cerebral mechanism of celecoxib for treating knee pain: study protocol for a randomized controlled parallel trial

    Celecoxib is frequently prescribed to treat knee osteoarthritis (KOA), but how celecoxib influences the activity of the central nervous system to alleviate chronic pain remains unclear.

    Chenjian Tang, **aohui Dong, Wenhua He, Shirui Cheng, Yang Chen, Yong Huang in Trials (2019)

  17. Article

    Open Access

    Traditional Chinese medicine (TCM) collaborative care for patients with axial spondyloarthritis (AcuSpA): protocol for a pragmatic randomized controlled trial

    Axial spondyloarthritis (AxSpA) is a chronic disease which results in fatigue, pain, and reduced quality of life (QoL). Traditional Chinese medicine (TCM), especially acupuncture, has shown promise in managing...

    Yu Heng Kwan, Warren Fong, **ang Ling Ang, Chuen Seng Tan, Bee Choo Tai in Trials (2019)

  18. Article

    Open Access

    Effect of dual-acupoint and single-acupoint electric stimulation on postoperative outcomes in elderly patients subjected to gastrointestinal surgery: study protocol for a randomized controlled trial

    Transcutaneous electric acupoint stimulation (TEAS) has shown benefits when used peri-operatively. However, the role of numbers of areas with acupoint stimulation is still unclear. Therefore, we report the pro...

    Zhi-hong Lu, Hai-long Dong, Jia-wen Huang-fu, **ao-jian Fan, Wei-xian Zhao in Trials (2018)

  19. Article

    Open Access

    Effects of alternate day calorie restriction and exercise on cardio-metabolic risk factors in overweight and obese adults: an exploratory randomized controlled study

    It has been recognized that alternate day calorie restriction (ADCR) or exercise has positive effects on cardio-metabolic risk factors. It is unclear whether the combined effect of ADCR and exercise (aerobic +...

    Minsuk Oh, Sue Kim, Ki-Yong An, Jihee Min, Hyuk In Yang, Junga Lee in BMC Public Health (2018)

  20. Article

    Open Access

    The efficacy and safety of herbal medicine BHH10 in postmenopausal women with osteoporosis: study protocol for a phase II, multicenter, randomized, double-blinded, placebo-controlled clinical trial

    Osteoporosis is becoming more prevalent in aging societies worldwide, and the economic burden attributable to osteoporotic fractures is substantial. The medications presently available to treat osteoporosis ha...

    Yeeun Cho, Seunghoon Lee, Jihye Kim, Jung Won Kang, Yong-Hyeon Baek in Trials (2018)

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