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Article
Instrumental Requirements for Non-Invasive Blood Glucose Measurement Using NIR Spectroscopy
The magnitude of spectral change in blood glucose measurements with diffuse reflectance spectroscopy is investigated. Spectral change is estimated by simulation of light propagation in skin tissue and measurem...
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Article
Temperature-Insensitive Measurement of Glucose Concentration Based on Near Infrared Spectroscopy and Partial Least Squares Analysis
Temperature-insensitive partial least squares analysis for glucose measurement is presented based on Near Infrared spectroscopy in the wavelength range from 1,250 to 1,800nm. Experiments are performed using aq...
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Development of a Retractor for Monitoring the Oxygenation State of Brain Tissue
In the majority of neurosurgical operations, brain refraction is one of the essential techniques. When the stress of retraction becomes too high, because of the occlusion of the blood vessel, saturation of oxy...
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Article
Time-Resolved Measurements of in vivo Optical Properties of Piglet Brain
The in vivo optical properties of a piglet brain were measured using a time-resolved system at three different wavelengths (759, 794, 824 nm). To separate the contribution of different head layers to the detected...
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Article
Fundamental Studies of Photon Migration in Biological Tissues and Their Application to Optical Tomography
This paper reviews the studies of photon migration in biological tissues and its application to optical tomography which were conducted in the Mechanical Engineering Laboratory of Japan’s Ministry of Internati...
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Article
Explanation of Human Skin Color by Multiple Linear Regression Analysis Based on the Modified Lambert-Beer Law
Quantitative analysis of human skin color is needed in the medical and cosmetic fields. Because of the strong light scattering by biological tissues, however, analysis of skin color has not yet been fully succ...
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Article
Determination of the Asymmetry Parameter and Scattering Coefficient of Turbid Media from Spatially Resolved Reflectance Measurements
We present a technique for determining the asymmetry parameter and scattering coefficient of turbid media from spatially resolved reflectance measurements. This technique will contribute to the development of ...
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Article
Frequency-Domain Measurements of Diffusing Photon Propagation in Solid Phantoms
Photon propagation in a highly scattering medium such as living tissue is well described by the photon diffusion equation. In a homogeneous and isotropic case, the equation has analytically been solved for a m...
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Article
Assessment of mitotic activity in pituitary adenomas and carcinomas
Assessment of mitotic activity represents one of the oldest and most routinely used histopathologic methods of evaluating the biological aggressiveness of human tumors. In the case of pituitary tumors, however...
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Article
Absorption Coefficient Measurements of Strongly Scattering Media Using Time-Resolved Transmittance of a Short Pulse in Near-Infrared (NIR) Wavelength Range
Absorption coefficient measurements of strongly scattering and weakly absorbing media have been performed using time resolved transmittance of a 100 fs pulse through a 30 mm slab containing latex spheres suspe...
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Article
Ultrastructural demonstration of calcitonin in osmium-fixed human medullary carcinoma of thyroid by the protein A-colloidal gold technique
In two medullary carcinomas of the thyroid gland two types of secretory granules were found electron microscopically in the cytoplasm of the tumour cells. The sizes of the granules in one case ranged 103–345 n...
