52 Result(s)

Article

Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study

The association of periodontal bacteria with lipid profile alteration remains largely unknown, although it has been suggested that chronic periodontitis increases the atherosclerotic risk. This cross-sectional...

Youn-Hee Choi, Takayuki Kosaka, Miki Ojima, Shinichi Sekine… in BMC Oral Health (2018)

Article

Impact of hypertension on the lifetime risk of coronary heart disease

The lifetime risk estimate conveys the probability of disease in the remaining lifetime for an index age. These estimates may be useful for general audience-targeted knowledge translation activities against hy...

Tanvir Chowdhury Turin, Tomonori Okamura, Arfan Raheen Afzal… in Hypertension Research (2016)

Article

Global strategies for non-communicable disease in terms of predictive, preventive and personalised medicine

Hiroyasu Iso, Yoshihiro Kokubo in EPMA Journal (2014)

Article

Erratum: Alcohol consumption and cardiovascular disease incidence in men with and without hypertension: the Suita study

Correction to: Hypertension Research (2013) 36, 58–64; doi:10.1038/hr.2012.133; published online 30 August 2012 After the publication of this article, the authors noticed an error in the Abstract. The number o...

Aya Higashiyama, Tomonori Okamura, Makoto Watanabe… in Hypertension Research (2013)

Article

Alcohol consumption and cardiovascular disease incidence in men with and without hypertension: the Suita study

The relationship between alcohol consumption and the risk for cardiovascular disease (CVD) is U-shaped, whereas alcohol drinking is linearly associated with blood pressure, and the CVD risk also increases line...

Aya Higashiyama, Tomonori Okamura, Makoto Watanabe… in Hypertension Research (2013)

Article

Association of intima-media thickening of carotid artery with genetic polymorphisms of the regulator of G-protein signaling 2 gene in patients with hypertension and in the general population

Regulator of G-protein signaling 2 (RGS2) is a key molecule in signal pathways of vasoactive peptides, such as angiotensin II and endothelin 1, and is believed to have an important role in the pathophysiology ...

Kei Kamide, Yoshihiro Kokubo, ** Yang, Shin Takiuchi… in Hypertension Research (2011)

Article

Associations of impaired glucose metabolism and dyslipidemia with cardiovascular diseases: what have we learned from Japanese cohort studies for individualized prevention and treatment?

Metabolic disorder is a modifiable risk factor for cardiovascular diseases (CVD), and lifestyle modification is the key to improving metabolic disorder. Diabetes mellitus has been shown to be a risk factor for...

Yoshihiro Kokubo in EPMA Journal (2011)

Article

The combined impact of blood pressure category and glucose abnormality on the incidence of cardiovascular diseases in a Japanese urban cohort: the Suita Study

Few prospective studies have examined the combined impact of blood pressure (BP) categories and glucose abnormalities on the incidence of cardiovascular disease (CVD) in the general Asian population. This stud...

Yoshihiro Kokubo, Tomonori Okamura, Makoto Watanabe… in Hypertension Research (2010)

Article

Impact of Metabolic Syndrome Components on the Incidence of Cardiovascular Disease in a General Urban Japanese Population: The Suita Study

Abdominal obesity is a prerequisite for some definitions of metabolic syndrome (MetS). We investigated the impact of MetS defined by two different criteria, which either did or did not require abdominal obesit...

Yoshihiro Kokubo, Tomonori Okamura, Yasunao Yoshimasa… in Hypertension Research (2008)

Article

Effects of the Y Chromosome on Cardiovascular Risk Factors in Japanese Men

Excess cardiovascular risk in men compared with women has been suggested to be partly explained by effects of the Y chromosome. However, inconsistent results have been reported on the Y chromosome's genetic in...

Yumiko Hiura, Yasue Fukushima, Yoshihiro Kokubo, Tomonori Okamura… in Hypertension Research (2008)

Article

Genetic Variations of CYP2C9 in 724 Japanese Individuals and Their Impact on the Antihypertensive Effects of Losartan

CYP2C9, a drug-metabolizing enzyme, converts the angiotensin II receptor blocker losartan to its active form, which is responsible for its antihypertensive effect. We resequenced CYP2C9 in 724 Japanese individ...

Tong Yin, Keiko Maekawa, Kei Kamide, Yoshiro Saito… in Hypertension Research (2008)

Article

Leptin Gene and Leptin Receptor Gene Polymorphisms Are Associated with Sweet Preference and Obesity

Leptin is an adipocyte-secreted hormone that regulates food intake and body weight, and that was recently reported to suppress sweet sensitivity in an animal model. We investigated the associations among sweet...

Einosuke Mizuta, Yoshihiro Kokubo, Itaru Yamanaka… in Hypertension Research (2008)

Article

Associations of Hypertension and Its Complications with Variations in the Xanthine Dehydrogenase Gene

Hyperuricemia and oxidative stress participate in the pathophysiology of hypertension and its complications. Xanthine dehydrogenase (XDH) produces urate and, in its oxidase isoform, reactive oxygen species. He...

** Yang, Kei Kamide, Yoshihiro Kokubo, Shin Takiuchi… in Hypertension Research (2008)

Article

Association of Genetic Polymorphisms of Endothelin-Converting Enzyme-1 Gene with Hypertension in a Japanese Population and Rare Missense Mutation in Preproendothelin-1 in Japanese Hypertensives

Endothelin-1 (EDN1), a 21-amino acid peptide, is a potent vasoconstrictor with various pharmacological responses. EDN1 is synthesized from a 212-amino acid precursor protein, preproEDN1, through multiple prote...

Mariko Banno, Hironori Hanada, Kei Kamide, Yoshihiro Kokubo… in Hypertension Research (2007)