5,481 Result(s)

Article

Tracking-seq reveals the heterogeneity of off-target effects in CRISPR–Cas9-mediated genome editing

The continued development of novel genome editors calls for a universal method to analyze their off-target effects. Here we describe a versatile method, called Tracking-seq, for in situ identification of off-t...

Ming Zhu, Runda Xu, Junsong Yuan, Jiacheng Wang, **aoyu Ren… in Nature Biotechnology (2024)

Article

Analysis of biopsy pathology and risk factors of lymph node metastasis in prostate cancer

To explore the relationship between biopsy pathology and lymph node metastasis in patients with prostate cancer (PCa), and to identify risk factors of lymph node metastasis (LNM).

Jie** Hu, **aorong Yang, Zhufeng **ong, Xun **e… in International Urology and Nephrology (2024)

Article

Nickel Induces Pyroptosis via the Nrf2/NLRP3 Pathway in Kidney of Mice

Nickel (Ni) is considered a toxic metal, and excessive exposure can cause kidney damage. This study was designed to explore whether nickel chloride (NiCl₂) can induce cell pyroptosis and its possible mechanism. H...

**g Li, **aoyu Dai, Shide Hu, Qiaolan Yang… in Biological Trace Element Research (2024)

Article

Enhanced service stability and thermoelectric performance in Cu_2−δSe-based composites

Pengfei Qiu, Xun Shi in Science China Materials (2024)

Article

Numerical Research of High-Voltage Conductors: Electric Field Characteristics in Ice-Covered Spaces

The icing of overhead high-voltage transmission lines not only caused accidents such as line dance down pole and flashover, but also lead to abnormal field strength on the line surface and distortion of electr...

**ngmou Liu, Hui Yang, Yan Gu, Lei Li… in Journal of Electrical Engineering & Techno… (2024)

Article

Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy

Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines, resulting in undesirable drug delivery efficacy and therapeutic outcomes....

Hanming Zhang, Honglin Gao, Yicong Zhang, Yikun Han, Qing Lin, Tao Gong… in Nano Research (2024)

Article

RUNX1/miR-429 feedback loop promotes growth, metastasis, and epithelial-mesenchymal transition in oral squamous cell carcinoma by targeting ITGB1

This study aimed to explore the role of miR-429 on the progression of oral squamous cell carcinoma (OSCC). OSCC cell lines were transfected with miR-429 mimic, pcDNA3.1-RUNX1, or pcDNA3.1-ITGB1, and their cell...

Xun Lu, Yiqiang Yang, Jia Chen, Tian Zhao… in Naunyn-Schmiedeberg's Archives of Pharmaco… (2024)

Article

Glassy gels toughened by solvent

Glassy polymers are generally stiff and strong yet have limited extensibility¹. By swelling with solvent, glassy polymers can become gels that are soft and weak yet have enhanced extensibility^1–3. The marked chan...

Meixiang Wang, Xun **ao, Salma Siddika, Mohammad Shamsi, Ethan Frey, Wen Qian… in Nature (2024)

Article

Sequential attention layer-wise fusion network for multi-view classification

Graph convolutional network has shown excellent performance in multi-view classification. Currently, to output a fused node embedding representation in multi-view scenarios, existing researches tend to ensure ...

Qing Teng, **bei Yang, Qiguo Sun… in International Journal of Machine Learning … (2024)

Article

Multiscale engineering of molecular electrocatalysts for the rapid hydrogen evolution reaction

Molecular electrocatalysts have demonstrated potential for the hydrogen evolution reaction (HER) due to their well-defined structures and high intrinsic activities. Achieving rapid production of hydrogen requi...

Huan Li, Zhan Jiang, Yubo Yuan, Yirong Tang, Jie Zao, Wentao Zhang… in Nano Research (2024)

Article

Energy consumption and surface roughness modelling for multi-objective optimisation of machining processes

Sustainability and precision are fundamental requirements for machining processes. In this study, novel energy consumption and surface roughness models are established to support the multi-objective (sustainab...

Chunhua Feng, Enguang Qin, Weidong Li… in The International Journal of Advanced Manu… (2024)

Article

Interstitial carbon induces enriched Cu^δ+ sites in Cu₂O nanoparticles to facilitate CO₂ electroreduction to C₂₊ products

The electrochemical CO₂ reduction reaction (CO₂RR) holds significant promise in advancing carbon neutrality. Develo** catalysts for the electrochemical CO₂RR to multi-carbon (C₂₊) products (e.g., C₂H₄) under in...

Haoran Wang, Rongbo Sun, Peigen Liu, Haohui Hu, Chen Ling, **ao Han… in Nano Research (2024)

Article

Phase engineering of polyoxometalate assembled superstructures

Superstructures of cluster assemblies have extraordinary properties compared with individual clusters, however, their precise synthesis and phase engineering remain challenging. Here the modular synthesis of a...

Fenghua Zhang, Haoyang Li, Zhong Li, Qingda Liu, Xun Wang in Nature Synthesis (2024)

Article

Investigation of factors affecting the thermal stability of silica-based shear thickening fluids

Recent experimental observation in thermal-induced gelation of silica-based shear thickening fluids (STFs) has necessitated the efforts to address the thermal instability of the STFs. The shear thickening beha...

Wenjian Wang, Shuai He, Ziwen Dong, Wei Huang, Xuke Li… in Korea-Australia Rheology Journal (2024)

Article

Study on the Destruction Process of Piers by Debris Flow Impact Using SPH-FEM Adaptive Coupling Method

Debris flows represent a prevalent natural disaster in mountainous regions, frequently devastating roads, bridges, and other vital transportation infrastructures due to their abrupt onset and immense destructi...

Changrong Yao, Chuan Xu, Xun Zhou, Qiaochao Liu… in KSCE Journal of Civil Engineering (2024)