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Article
Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors
Bacterial outer membrane vesicles (OMVs) are potent immunostimulants of regulating the tumor microenvironment (TME) for immunotherapy, and can be used to deliver drugs. However, the severe systemic inflammator...
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Article
Open AccessHomolytic H2 dissociation for enhanced hydrogenation catalysis on oxides
The limited surface coverage and activity of active hydrides on oxide surfaces pose challenges for efficient hydrogenation reactions. Herein, we quantitatively distinguish the long-puzzling homolytic dissociat...
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Article
Open AccessIron accumulation induced by hepcidin1 knockout accelerates the progression of aging osteoporosis
Iron accumulation is associated with osteoporosis. This study aims to explore the effect of chronic iron accumulation induced by hepcidin1 deficiency on aging osteoporosis.
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Article
Open AccessExperimental study on failure characteristics and rheological properties of pillar-like rock samples with different shapes
The stability of coal pillar is extremely important to the control of rock strata movement and surface subsidence. It is of great significance for mining design to analyze the stability and failure characteris...
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Article
Measurement-device-independent quantum key agreement based on entanglement swap**
Quantum key agreement (QKA) is an important cryptographic primitive that plays a pivotal role in private communications. However, in practical implementations of QKA, the flaws in participants’ detectors may b...
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Article
An Efficient Bifunctional Core–Shell MIL-101(Cr)@MOF-867 Composite to Catalyze Deacetalization–Knoevenagel Tandem Reaction
By growing one metal organic frameworks (MOFs) on different metal organic frameworks plays an important role in catalytic reaction, but its cooperative catalysis in tandem reaction is an undeveloped field yet,...
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Article
Open AccessEpidemiological characteristics and temporal-spatial clustering analysis on human brucellosis in Jiangsu Province, 2006–2021
The marked increase in the incidence rate of brucellosis is a serious public health concern in Jiangsu Province. However, its temporal and spatial distribution has not been studied in depth. The main purpose o...
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Article
Open AccessMagnetic vagus nerve stimulation alleviates myocardial ischemia-reperfusion injury by the inhibition of pyroptosis through the M2AChR/OGDHL/ROS axis in rats
Myocardial ischemia-reperfusion (I/R) injury is accompanied by an imbalance in the cardiac autonomic nervous system, characterized by over-activated sympathetic tone and reduced vagal nerve activity. In our pr...
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Article
Open AccessMetatranscriptome of human lung microbial communities in a cohort of mechanically ventilated COVID-19 Omicron patients
The Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) infected a substantial proportion of Chinese population, and understanding the factors underlying the severity of the dis...
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Article
Open AccessFAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression
Invasion and metastasis are the main causes of unfavourable prognosis in patients diagnosed with bladder cancer. The efficacy of immunotherapy in bladder cancer remains suboptimal due to the presence of an imm...
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Article
Open AccessCharacteristics and prognostic implications of peripheral blood lymphocyte subsets in patients with anti-MDA5 antibody positive dermatomyositis-interstitial lung disease
To examine the characteristics of blood lymphocyte subsets in dermatomyositis-interstitial lung disease (DM-ILD) inflicted patients with positive anti-melanoma differentiation-associated gene 5 (anti-MDA5), as...
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Article
Open AccessIdentification of PCB congeners and their thresholds associated with diabetes using decision tree analysis
Few studies have investigated the potential combined effects of multiple PCB congeners on diabetes. To address this gap, we used data from 1244 adults in the National Health and Nutrition Examination Survey (N...
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Article
Open AccessTalaromyces marneffei suppresses macrophage inflammation by regulating host alternative splicing
Talaromyces marneffei (T. marneffei) immune escape is essential in the pathogenesis of talaromycosis. It is currently known that T. marneffei achieves immune escape through various strategies. However, the role o...
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Article
Deformation mechanism and treatment technology research of coal pillars in acute inclined goafs under expressway
When the expressway crosses the goafs inevitably, the design is generally to build the road on coal pillars as much as possible. However, the existing coal pillars are often unable to meet relevant requirement...
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Article
Fluorinated Colorless Polyimides with High Heat-resistance and Low Birefringence
The development of optical films with high transparency, high thermal resistance and low birefringence remains a challenge in the flexible display industry. In this work, we designed and synthesized a series o...
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Article
Effect of liquid viscoelasticity on the interactions between cavitation bubbles and free surfaces
The influence of liquid viscoelasticity on the interaction between cavitation bubbles and free surfaces is of great practical significance in understanding bubble dynamics in biological systems. A series of mi...
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Article
Outstanding strength and conductivity of metallic glass composites with multiscale configuration
Cu-based composites with multiscale configuration for electrical contact applications are fabricated via a ball milling (BM)-spark plasma sintering (SPS)-aging process. Synergistic strengthening of the Cu allo...
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Article
Open AccessA novel UHPLC‒MS/MS method for quantitative analysis of zanubrutinib in rat plasma: application to an in vivo interaction study between zanubrutinib and triazole antifungal
This study establishes a UHPLC‒MS/MS method for the detection of zanubrutinib and explores its interaction with fluconazole and isavuconazole in rats.
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Article
Measurement of the 232Th(n,f) cross section in the 1–200 MeV range at the CSNS Back-n
The 232Th(n,f) cross section is very important in basic nuclear physics and applications based on the Th/U fuel cycle. Using the time-of-flight method and a multi-cell fast-fission ionization chamber, a novel mea...
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Article
Open AccessBioorthogonal Engineered Virus-Like Nanoparticles for Efficient Gene Therapy
A virus-like nanoparticle (reBiosome) was developed via site-specific codon mutation for displaying unnatural amino acid (Azi) on virus envelope protein at a rational site,...
