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Article
Assessment of heavy metals in surface water, sediment and macrozoobenthos in inland rivers: a case study of the Heihe River, Northwest China
Long-term retention and accumulation of heavy metals in surface water and sediment pose a great threat to the sustainable development of aquatic ecosystems and human health. In this research, macrozoobenthos, ...
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Article
Cachexia Versus Sarcopenia in Clinical Characteristics and Prognostic Value After Radical Gastrectomy for Gastric Cancer: A Large-Scale Prospective Study
Sarcopenia and cachexia are two predictors of adverse clinical outcomes, but they are partly overlap**. We aimed to compare the characteristics and prognostic value of cachexia and sarcopenia in patients aft...
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Article
Open AccessSmall lesion depiction and quantification accuracy of oncological 18F-FDG PET/CT with small voxel and Bayesian penalized likelihood reconstruction
To investigate the influence of small voxel Bayesian penalized likelihood (SVB) reconstruction on small lesion detection compared to ordered subset expectation maximization (OSEM) reconstruction using a clinic...
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Article
Open AccessEfficacy and safety of long-term transcutaneous electroacupuncture versus sham transcutaneous electroacupuncture for delayed gastric emptying after distal gastrectomy: study protocol for a randomized, patient-assessor blinded, controlled trial
Delayed gastric emptying (DGE) after distal gastrectomy impacts patients’ nutritional status and quality of life. The current treatments of DGE seem unsatisfactory or need invasive interventions. It is unknown...
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Article
Efficient adsorption removal and adsorption mechanism of basic fuchsin by recyclable Fe3O4@CD magnetic microspheres
Excessive discharge of dye wastewater has brought serious harm to human health and the environment. In this paper, a magnetic absorbent, ferroferric oxide@β-cyclodextrin (Fe3O4@CD), was prepared for the efficient...
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Article
Open AccessActive constituent of Polygala tenuifolia attenuates cognitive deficits by rescuing hippocampal neurogenesis in APP/PS1 transgenic mice
Alzheimer’s disease (AD) is the most common dementia worldwide, and there is still no satisfactory drug or therapeutic strategy. Polygala tenuifolia is a traditional Chinese medicine with multiple neuroprotective...
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Article
Physiological clearance of amyloid-beta by the kidney and its therapeutic potential for Alzheimer’s disease
Amyloid-β (Aβ) accumulation in the brain is a pivotal event in the pathogenesis of Alzheimer’s disease (AD), and its clearance from the brain is impaired in sporadic AD. Previous studies suggest that approxima...
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Article
Blood cell-produced amyloid-β induces cerebral Alzheimer-type pathologies and behavioral deficits
It is traditionally believed that cerebral amyloid-beta (Aβ) deposits are derived from the brain itself in Alzheimer’s disease (AD). Peripheral cells such as blood cells also produce Aβ. The role of peripheral...
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Article
Parkin, an E3 Ubiquitin Ligase, Plays an Essential Role in Mitochondrial Quality Control in Parkinson’s Disease
Parkinson’s disease (PD), as one of the complex neurodegenerative disorders, affects millions of aged people. Although the precise pathogenesis remains mostly unknown, a significant number of studies have demo...
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Article
Open AccessThe differential demographic pattern of coronavirus disease 2019 fatality outside Hubei and from six hospitals in Hubei, China: a descriptive analysis
The coronavirus disease 2019 (COVID-19) epidemic has been largely controlled in China, to the point where case fatality rate (CFR) data can be comprehensively evaluated.
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Article
An experimental study of mitigating coastal sand dune erosion by microbial- and enzymatic-induced carbonate precipitation
Due to more extreme weather events and accelerating sea-level rise, coastal sand dunes are subjected to more frequent storm wave inundation and surge impacts, which contribute to widespread coastal erosion pro...
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Article
Open AccessAmyloid-beta uptake by blood monocytes is reduced with ageing and Alzheimer’s disease
Deficits in the clearance of amyloid β-protein (Aβ) play a pivotal role in the pathogenesis of sporadic Alzheimer’s disease (AD). The roles of blood monocytes in the development of AD remain unclear. In this s...
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Article
Connexin 36 Mediates Orofacial Pain Hypersensitivity Through GluK2 and TRPA1
Trigeminal neuralgia is a debilitating condition, and the pain easily spreads to other parts of the face. Here, we established a mouse model of partial transection of the infraorbital nerve (pT-ION) and found ...
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Article
Down-Regulated CUEDC2 Increases GDNF Expression by Stabilizing CREB Through Reducing Its Ubiquitination in Glioma
Abnormally high expression of glial cell line-derived neurotrophic factor (GDNF) derived from glioma cells has essential impacts on gliomagenesis and development, but the molecular basis underlying increased G...
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Article
Open AccessThe value of 18F-PSMA-1007 PET/CT in identifying non-metastatic high-risk prostate cancer
Clinical management decisions on prostate cancer (PCa) are often based on a determination of risk. 68Ga-prostate-specific membrane antigen (PSMA)-11-positron emission tomography (PET)/computer tomography (CT) is ...
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Article
Open AccessChromosome-level genome assembly of a parent species of widely cultivated azaleas
Azaleas (Ericaceae) comprise one of the most diverse ornamental plants, renowned for their cultural and economic importance. We present a chromosome-scale genome assembly for Rhododendron simsii, the primary ance...
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Article
Open AccessDeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1H-NMR probe
Characterization of the dynamic conformational changes in membrane protein signaling complexes by nuclear magnetic resonance (NMR) spectroscopy remains challenging. Here we report the site-specific incorporati...
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Article
Open AccessSuppression of histone deacetylases by SAHA relieves bone cancer pain in rats via inhibiting activation of glial cells in spinal dorsal horn and dorsal root ganglia
Robust activation of glial cells has been reported to occur particularly during the pathogenesis of bone cancer pain (BCP). Researchers from our group and others have shown that histone deacetylases (HDACs) pl...
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Article
Urotensin II and urantide exert opposite effects on the cellular components of atherosclerotic plaque in hypercholesterolemic rabbits
Increasing levels of plasma urotensin II (UII) are positively associated with atherosclerosis. In this study we investigated the role of macrophage-secreted UII in atherosclerosis progression, and evaluated th...
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Article
Sentiment classification and computing for online reviews by a hybrid SVM and LSA based approach
For the current online reviews sentiment classification method, there are some problems such as serious text sparseness and coarse granularity of sentiment calculation. In this paper, the emotion in online rev...
