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Article
Open AccessMRI assessment of glutamine uptake correlates with the distribution of glutamine transporters and cancer stem cell markers
Glutamine provides carbon and nitrogen for macromolecular synthesis and participates in adenosine triphosphate (ATP) generation, anabolic metabolism, redox homeostasis, cell signaling, and cancer stem cell (CS...
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Article
Open AccessSuppressive effect of α-mangostin for cancer stem cells in colorectal cancer via the Notch pathway
Since colon cancer stem cells (CSCs) play an important role in chemoresistance and in tumor recurrence and metastasis, targeting of CSCs has emerged as a sophisticated strategy for cancer therapy. α-mangostin ...
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Article
Open AccessComparative effectiveness of second-line biological therapies for ulcerative colitis and Crohn’s disease in patients with prior failure of anti-tumour necrosis factor treatment
Therapeutic options for inflammatory bowel disease (IBD) have increased since the introduction of tumour necrosis factor (TNF) inhibitors a few decades ago. However, direct comparisons of the effectiveness of ...
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Article
Open AccessC-reactive protein is associated with postoperative outcomes in patients with intestinal Behçet’s disease
Patients with intestinal Behçet’s disease (BD) frequently undergo intestinal resections, which significantly affects postoperative morbidity and mortality. The aim of this study was to identify the association...
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Article
Avoiding heating interference and guided thermal conduction in stretchable devices using thermal conductive composite islands
The miniaturization and high integration of devices demand significant thermal management materials. Current technologies for the thermal management of electronics show some limitations in the case of multiple...
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Article
An on-skin platform for wireless monitoring of flow rate, cumulative loss and temperature of sweat in real time
Monitoring the flow rate, cumulative loss and temperature of sweat can provide valuable physiological insights for the diagnosis of thermoregulatory disorders and illnesses related to heat stress. However, obt...
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Article
Feasibility of low-dose digital subtraction angiography protocols for the endovascular treatment of intracranial dural arteriovenous fistulas
Among neurointerventional procedures, the embolization of complex shunt lesions usually requires more radiation dose. We aimed to evaluate the procedural outcome and safety in using low-dose DSA protocols for ...
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Article
Open AccessFusobacterium nucleatum in biopsied tissues from colorectal cancer patients and alcohol consumption in Korea
The roles of individual bacteria and their relationship in the development of colorectal cancer (CRC) remain unclear. We aimed to determine the prevalence of CRC-associated bacteria using quantitative real-tim...
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Article
Open Access5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
5-Fluorouracil (5-FU) remains the first-line treatment for colorectal cancer (CRC). Although 5-FU initially de-bulks the tumor mass, recurrence after chemotherapy is the barrier to effective clinical outcomes ...
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Article
Open AccessDeep Learning Hybrid Method to Automatically Diagnose Periodontal Bone Loss and Stage Periodontitis
We developed an automatic method for staging periodontitis on dental panoramic radiographs using the deep learning hybrid method. A novel hybrid framework was proposed to automatically detect and classify the ...
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Article
Open AccessUpfront radical surgery with total mesorectal excision followed by adjuvant FOLFOX chemotherapy for locally advanced rectal cancer (TME-FOLFOX): an open-label, multicenter, phase II randomized controlled trial
Preoperative chemoradiotherapy (PCRT) followed by surgery and adjuvant chemotherapy is the current standard treatment for stage II/III rectal cancer. However, radiotherapy in the pelvic area is commonly associ...
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Article
Open Accessβ-catenin activation down-regulates cell-cell junction-related genes and induces epithelial-to-mesenchymal transition in colorectal cancers
WNT signaling activation in colorectal cancers (CRCs) occurs through APC inactivation or β-catenin mutations. Both processes promote β-catenin nuclear accumulation, which up-regulates epithelial-to-mesenchymal tr...
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Article
Open AccessProteomics-based functional studies reveal that galectin-3 plays a protective role in the pathogenesis of intestinal Behçet’s disease
The pathogenesis of intestinal Behçet’s disease (BD) remains poorly understood. Therefore, we aimed to discover and validate biomarkers using proteomics analysis and subsequent functional studies. After two-di...
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Article
Fabrication of Randomly Stooped Polymer Nanohairs Using Scattered Electron Flood under Ambient Condition
Despite attractive applications of randomly oriented nanostructures with high aspect ratio, their fabrication suffers from both complicated processes and lack of materials. In this letter, we present a simple ...
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Article
Open AccessNext-generation sequencing with comprehensive bioinformatics analysis facilitates somatic mosaic APC gene mutation detection in patients with familial adenomatous polyposis
Familial adenomatous polyposis (FAP) is an autosomal dominant colorectal tumor characterized by numerous adenomatous colonic polyps that often lead to colon cancer. Although most patients with FAP harbored ger...
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Article
Photovoltaic Modules Using a Galinstan Paste Interconnection
A shingled silicon photovoltaic (PV) module without busbars on the front side of a solar cell can increase the light-receiving area and provide more power than a conventional PV module. However, there are seve...
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Article
Outcomes of stent insertion and mortality in obstructive stage IV colorectal cancer patients through 10 year duration
Colorectal stents are frequently used in patients with stage IV colorectal cancer with obstruction. However, there are only few studies on changes in outcomes of these patients and on the effect of stents on o...
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Article
Open AccessLong-term outcomes according to additional treatments after endoscopic resection for rectal small neuroendocrine tumors
The present study aimed to investigate treatment strategies determining additional treatment after endoscopic resection (ER) of rectal neuroendocrine tumor (NET)s and long-term outcomes of endoscopically resec...
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Article
Open AccessMicrosatellite instability test using peptide nucleic acid probe-mediated melting point analysis: a comparison study
Analysis of high microsatellite instability (MSI-H) phenotype in colorectal carcinoma (CRC) is important for evaluating prognosis and choosing a proper adjuvant therapy. Although the conventional MSI analysis ...
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Article
Does Medical Acceleration Improve Outcomes in Ulcerative Colitis Patients Who Are in Clinical Remission but Have Endoscopic Inflammation?
Discrepancies between clinical symptoms and mucosal inflammation have been reported in up to 50% of patients with ulcerative colitis (UC). However, there are no guidelines and only limited information for appr...
