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Article
Open AccessPAX4 loss of function increases diabetes risk by altering human pancreatic endocrine cell development
The coding variant (p.Arg192His) in the transcription factor PAX4 is associated with an altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for beta cell formation but its...
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Article
The associations of non-essential metal mixture with fasting plasma glucose among Chinese older adults without diabetes
The evidence about the effect of non-essential metal mixture on fasting plasma glucose (FPG) levels among older adults without diabetes is limited. This study aims to estimate the individual and joint relation...
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Article
Open AccessA streamlined guide RNA screening system for genome editing in Sorghum bicolor
Genome editing tools derived from clustered regularly interspaced short palindromic repeats (CRISPR) systems have been developed for generating targeted mutations in plants. Although these tools hold promise f...
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Article
Open AccessCamrelizumab combined with apatinib in patients with first-line platinum-resistant or PD-1 inhibitor resistant recurrent/metastatic nasopharyngeal carcinoma: a single-arm, phase 2 trial
Immunotherapy combined with antiangiogenic targeted therapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for refractory recurrent/metastatic nasopharyngeal carcinom...
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Article
Open AccessA common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep
A comorbidity of chronic pain is sleep disturbance. Here, we identify a dual-functional ensemble that regulates both pain-like behaviour induced by chronic constrictive injury or complete Freund’s adjuvant, an...
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Article
Open AccessMeasurement of the \( ^{181} \) Ta( \(n,\gamma \) ) cross sections up to stellar s-process temperatures at the CSNS Back-n
The neutron capture cross section of \( ^{181} \) 181 ...
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Article
New Interpretation of Neonatal Outcomes by Phenotypically Classified Preterm Syndrome: A Retrospective Cohort Study
The global aim to lower preterm birth rates has been hampered by the insufficient and incomplete understanding of its etiology, classification, and diagnosis. This study was designed to evaluate the associatio...
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Article
Molecular characterization of a novel umbra-like virus from Thuja orientalis (arborvitae) in South Korea
A novel umbra-like virus was identified in arborvitae in South Korea using RNA sequencing (RNA-seq). The virus identified was tentatively named "arborvitae umbra-like virus" (AULV) and contained a 4,300-nucleo...
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Article
Open AccessGenomic analysis of plasma circulating tumor DNA in patients with heavily pretreated HER2 + metastatic breast cancer
We explored accumulated genomic alterations in patients with heavily treated HER2 + metastatic breast cancer enrolled in the KCSG BR18-14/KM10B trial. Targeted sequencing was performed with circulating tumor D...
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Article
Electronic origin of the unusual thermal properties of copper-based semiconductors: The s-d coupling-induced large phonon anharmonicity
Copper (Cu)-based materials (such as cuprates, Cu chalcogenides, and Cu halides) often exhibit unusual properties such as superconductivity, ultralow thermal conductivity, and superionicity. However, the elect...
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Article
Open AccessSix Spain Thymus essential oils composition analysis and their in vitro and in silico study against Streptococcus mutans
Streptococcus mutans is a well-known oral pathogen that plays a critical role in the development of dental caries. Many studies have been directed to discover the chemical compounds present in natural products to...
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Article
Dye-encapsulated metal–organic framework composites for highly sensitive and selective sensing of oxytetracycline based on ratiometric fluorescence
Herein, we reported a class of well-fluorescence-stabilized rare-earth-free ratiometric fluorescent probe for highly sensitive visual detection of oxytetracycline (OTC), which was fabricated by encapsulation o...
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Article
Measurable residual disease detected by flow cytometry independently predicts prognoses of NPM1-mutated acute myeloid leukemia
Acute myeloid leukemia (AML) with NPM1 mutation is a distinct genetic entity with favorable outcomes. Nevertheless, emerging evidence suggests that NPM1-mutated AML is still a highly heterogeneous disorder. In th...
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Article
The impact of low-carbon city pilot policy on green total-factor productivity in China’s cities
Whether the low-carbon city construction can coordinate urban economy and environment has attracted increasing attention in recent years. In this study, the impact of low-carbon city pilot (LCCP) policy on urb...
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Article
Ultralarge-scale anomalous phase separation discovered in a Cr-Fe-Co-Ni-Zr high-entropy metallic glass system
Anomalous phase separation in metallic glasses is a longstanding issue that has been controversial since it was first implied in 1969 due to the influence of microstructure artifacts and the lack of direct lar...
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Article
Measurement of the \(\varvec{^{nat}}\) Eu( \(\varvec{n,\gamma }\) ) cross section up to 500 keV at the CSNS Back-n facility, and the stellar \(\varvec{^{151,153}}\) Eu( \(\varvec{n,\gamma }\) ) cross section at s-process temperatures
In nuclear astrophysics, the nuclides \(^{151}\) 151 ...
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Article
Improved BV-based quantum attack on block ciphers
Due to the powerful computing capability of quantum computers, cryptographic researchers have applied quantum algorithms to cryptanalysis and obtained many interesting results. Finding the linear structure of ...
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Article
Open AccessStress distribution in pediatric zirconia crowns depending on different tooth preparation and cement type: a finite element analysis
In clinical settings, tooth preparation for prefabricated zirconia crowns (PZCs) in the primary dentition varies widely. However, knowledge about the biomechanical behavior of PZCs in various clinical settings...
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Article
Efficacy and Mechanism of Buxue Yimu Pills on Gynecological Anemia: A Combination of Clinical and Network Pharmacology Study
To compare the clinical efficacy and safety of oral administration of Buxue Yimu Pills (BYP, 补血益母丸), ferrous sulfate (FS), and the combination of BYP and FS on gynecological anemia, and investigate the mechani...
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Article
Outer membrane protein of OmpF contributes to swimming motility, biofilm formation, osmotic response as well as the transcription of maltose metabolic genes in Citrobacter werkmanii
Bacterial outer membrane proteins (Omps) are essential for environmental sensing, stress responses, and substance transport. Our previous study discovered that OmpA contributes to planktonic growth, biocide re...
