386 Result(s)

Article

Machine learning-based extrachromosomal DNA identification in large-scale cohorts reveals its clinical implications in cancer

The clinical implications of extrachromosomal DNA (ecDNA) in cancer therapy remain largely elusive. Here, we present a comprehensive analysis of ecDNA amplification spectra and their association with clinical ...

Shixiang Wang, Chen-Yi Wu, Ming-Ming He, Jia-**n Yong… in Nature Communications (2024)

Article

Addendum: Cellular differentiation into hyphae and spores in halophilic archaea

Shu-Kun Tang, **ao-Yang Zhi, Yao Zhang, Kira S. Makarova… in Nature Communications (2024)

Article

Identification of gene signatures and molecular mechanisms underlying the mutual exclusion between psoriasis and leprosy

Leprosy and psoriasis rarely coexist, the specific molecular mechanisms underlying their mutual exclusion have not been extensively investigated. This study aimed to reveal the underlying mechanism responsible...

You-Wang Lu, Rong-**g Dong, Lu-Hui Yang, Jiang Liu, Ting Yang… in Scientific Reports (2024)

Article

A biomarker panel of C-reactive protein, procalcitonin and serum amyloid A is a predictor of sepsis in severe trauma patients

Severe trauma could induce sepsis due to the loss of control of the infection, which may eventually lead to death. Accurate and timely diagnosis of sepsis with severe trauma remains challenging both for clinic...

Mei Li, Yan-jun Qin, **n-liang Zhang, Chun-hua Zhang, Rui-juan Ci… in Scientific Reports (2024)

Article

Identification of the length and location of the A1 pulley combining palpation technique with palm landmarks: a cadaveric study

Through anatomical morphology, to accumulate the relevant parameters of the A1 pulley of each adult finger. A total of 100 fingers were selected, dissected layer by layer, and the A1 pulley and neurovascular o...

Wei-xing Zhong, Jun-hua Li, Zu-jiang Chen, Wei-jie Peng, Rui-bin Gu… in Scientific Reports (2023)

Article

Biomechanical and histomorphological analysis of the mandible in rats with chronic kidney disease

The present study aimed to investigate the biomechanical and histomorphological features of mandibles in an adenine-induced chronic kidney disease–mineral and bone disorder (CKD-MBD) rat model of CKD. A total ...

Ta-la Hu, Jun Chen, Shen-quan Shao, Le-le Li, Can Lai, Wu-niri Gao… in Scientific Reports (2023)

Article

Effect of miR-206 on lower limb ischemia–reperfusion injury in rat and its mechanism

Lower limb ischemia–reperfusion is a common pathological process during clinical surgery. Because lower limb ischemia–reperfusion usually aggravates ischemia-induced skeletal muscle tissue injury after lower l...

Hui Wang, Meng-Jie Shi, Zhang-Qin Hu, Lin Miao, He-Shi Cai… in Scientific Reports (2023)

Article

Myeloid cells interact with a subset of thyrocytes to promote their migration and follicle formation through NF-κB

The pathogenesis of thyroid dysgenesis (TD) is not well understood. Here, using a combination of single-cell RNA and spatial transcriptome sequencing, we identify a subgroup of NF-κB-activated thyrocytes locat...

Rui-Meng Yang, Shi-Yang Song, Feng-Yao Wu, Rui-Feng Yang… in Nature Communications (2023)

Article

Fracture detection in pediatric wrist trauma X-ray images using YOLOv8 algorithm

Hospital emergency departments frequently receive lots of bone fracture cases, with pediatric wrist trauma fracture accounting for the majority of them. Before pediatric surgeons perform surgery, they need to ...

Rui-Yang Ju, Weiming Cai in Scientific Reports (2023)

Article

Diversity and evolution of the MHC class II DRB gene in the Capra sibirica experienced a demographic fluctuation in China

The major histocompatibility complex (MHC) genes are the most polymorphic genes in vertebrates, and their proteins play a critical role in adaptive immunity for defense against a variety of pathogens. MHC dive...

Pei-Pei Dong, Rui-Rui Wang, Shamshidin Abduriyim in Scientific Reports (2023)

Article

Gut microbiota impacts bone via Bacteroides vulgatus-valeric acid-related pathways

Although the gut microbiota has been reported to influence osteoporosis risk, the individual species involved, and underlying mechanisms, remain largely unknown. We performed integrative analyses in a Chinese ...

Xu Lin, Hong-Mei **ao, Hui-Min Liu, Wan-Qiang Lv… in Nature Communications (2023)

Article

A single amino acid substitution in the capsid protein of Zika virus contributes to a neurovirulent phenotype

Increasing evidence shows the African lineage Zika virus (ZIKV) displays a more severe neurovirulence compared to the Asian ZIKV. However, viral determinants and the underlying mechanisms of enhanced virulence...

Guang-Yuan Song, **ng-Yao Huang, Meng-Jiao He, Hang-Yu Zhou… in Nature Communications (2023)

Article

The liver microenvironment orchestrates FGL1-mediated immune escape and progression of metastatic colorectal cancer

Colorectal cancer (CRC) patients with liver metastases usually obtain less benefit from immunotherapy, and the underlying mechanisms remain understudied. Here, we identify that fibrinogen-like protein 1 (FGL1)...

Jia-Jun Li, **-Hong Wang, Tian Tian, Jia Liu, Yong-Qiang Zheng… in Nature Communications (2023)

Article

Integrated single-cell and spatial transcriptomics reveals heterogeneity of fibroblast and pivotal genes in psoriasis

Psoriasis, which is one of the most common skin diseases, involves an array of complex immune constituents including T cells, dendritic cells and monocytes. Particularly, the cytokine IL17A, primarily generate...

Cong-cong He, Tian-cong Song, Rui-qun Qi, **ng-Hua Gao in Scientific Reports (2023)

Article

Anomalous spin current anisotropy in a noncollinear antiferromagnet

Cubic materials host high crystal symmetry and hence are not expected to support anisotropy in transport phenomena. In contrast to this common expectation, here we report an anomalous anisotropy of spin curren...

Cuimei Cao, Shiwei Chen, Rui-Chun **ao, Zengtai Zhu, Guoqiang Yu… in Nature Communications (2023)

Article

Author Correction: A translational regulator MHZ9 modulates ethylene signaling in rice

Yi-Hua Huang, Jia-Qi Han, Biao Ma, Wu-Qiang Cao, **n-Kai Li… in Nature Communications (2023)

Article

A translational regulator MHZ9 modulates ethylene signaling in rice

Ethylene plays essential roles in rice growth, development and stress adaptation. Translational control of ethylene signaling remains unclear in rice. Here, through analysis of an ethylene-response mutant mhz9, w...

Yi-Hua Huang, Jia-Qi Han, Biao Ma, Wu-Qiang Cao, **n-Kai Li… in Nature Communications (2023)

Article

The effectiveness of the puncture channel plugging for reduction of complications after CT-guided percutaneous transthoracic needle biopsy

The effect of plugging the puncture channel with a mixture of hemocoagulase injection on the complications of CT-guided percutaneous transthoracic need biopsy (PTNB) was discussed. The medical records of PTNB ...

Dong-xu Wang, Yu-guang Wang, Guo-xu Ding, Bo Li, Rui-nan Liu… in Scientific Reports (2023)

Article

A valuable subarachnoid space named the occipito-atlantal cistern

The cisterna magna has been defined as the space between the inferior margin of the cerebellar vermis to the level of the foramen magnum, while an enlarged dorsal subarachnoid space at the occipito-cervical ju...

Yun-Fei Li, Rui-Xue Wei, Kai-Qi Yang, Gary D. Hack, Yan-Yan Chi… in Scientific Reports (2023)