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Open AccessTrends in health workers’ compliance with outpatient malaria case-management guidelines across malaria epidemiological zones in Kenya, 2010–2016
Health workers' compliance with outpatient malaria case-management guidelines has been improving, specifically regarding the universal testing of suspected cases and the use of artemisinin-based combination th...
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Article
Open AccessMalaria infection, disease and mortality among children and adults on the coast of Kenya
Malaria transmission has recently fallen in many parts of Africa, but systematic descriptions of infection and disease across all age groups are rare. Here, an epidemiological investigation of parasite prevale...
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Open AccessA systematic review of changing malaria disease burden in sub-Saharan Africa since 2000: comparing model predictions and empirical observations
The most widely used measures of declining burden of malaria across sub-Saharan Africa are predictions from geospatial models. These models apply spatiotemporal autocorrelations and covariates to parasite prev...
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Article
Open AccessEstimating the burden of iron deficiency among African children
Iron deficiency (ID) is a major public health burden in African children and accurate prevalence estimates are important for effective nutritional interventions. However, ID may be incorrectly estimated in Afr...
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Article
Open AccessProlonged health worker strikes in Kenya- perspectives and experiences of frontline health managers and local communities in Kilifi County
While health worker strikes are experienced globally, the effects can be worst in countries with infrastructural and resource challenges, weak institutional arrangements, underdeveloped organizational ethics c...
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Open AccessInvestigating the drivers of the spatio-temporal patterns of genetic differences between Plasmodium falciparum malaria infections in Kilifi County, Kenya
Knowledge of how malaria infections spread locally is important both for the design of targeted interventions aiming to interrupt malaria transmission and the design of trials to assess the interventions. A pr...
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Open AccessObservational study: 27 years of severe malaria surveillance in Kilifi, Kenya
Many parts of Africa have witnessed reductions in Plasmodium falciparum transmission over the last 15 years. Since immunity to malaria is acquired more rapidly at higher transmission, the slower acquisition of im...
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Open AccessRepeated clinical malaria episodes are associated with modification of the immune system in children
There are over 200 million reported cases of malaria each year, and most children living in endemic areas will experience multiple episodes of clinical disease before puberty. We set out to understand how freq...
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Open AccessSingle low-dose primaquine for blocking transmission of Plasmodium falciparum malaria – a proposed model-derived age-based regimen for sub-Saharan Africa
In 2012, the World Health Organization recommended blocking the transmission of Plasmodium falciparum with single low-dose primaquine (SLDPQ, target dose 0.25 mg base/kg body weight), without testing for glucose-...
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Open AccessTrends in bednet ownership and usage, and the effect of bednets on malaria hospitalization in the Kilifi Health and Demographic Surveillance System (KHDSS): 2008–2015
Use of bednets reduces malaria morbidity and mortality. In Kilifi, Kenya, there was a mass distribution of free nets to children < 5 years in 2006. In 2009, a new policy was implemented to offer bednets to pre...
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Open AccessExamining the human infectious reservoir for Plasmodium falciparum malaria in areas of differing transmission intensity
A detailed understanding of the human infectious reservoir is essential for improving malaria transmission-reducing interventions. Here we report a multi-regional assessment of population-wide malaria transmis...
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Article
The prevalence of Plasmodium falciparum in sub-Saharan Africa since 1900
Spatial and temporal modelling of a large dataset of Plasmodium falciparum prevalence rates reveals cycles and trends of malaria transmission in sub-Saharan Africa over a 115 year period.
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Open AccessPlasmodium falciparum malaria parasite var gene expression is modified by host antibodies: longitudinal evidence from controlled infections of Kenyan adults with varying natural exposure
The PfEMP1 family of Plasmodium falciparum antigens play a key role in pathogenesis of severe malaria through their insertion into the surface of parasite infected erythrocytes, and adhesion to host cells. Previo...
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Open AccessEffect of transmission intensity on hotspots and micro-epidemiology of malaria in sub-Saharan Africa
Malaria transmission intensity is heterogeneous, complicating the implementation of malaria control interventions. We provide a description of the spatial micro-epidemiology of symptomatic malaria and asymptom...
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Article
Open AccessEfficacy of text-message reminders on paediatric malaria treatment adherence and their post-treatment return to health facilities in Kenya: a randomized controlled trial
Short Message Service (SMS) reminders have been suggested as a potential intervention for improving adherence to medications and health facility attendance.
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Open AccessThe effect of declining exposure on T cell-mediated immunity to Plasmodium falciparum – an epidemiological “natural experiment”
Naturally acquired immunity to malaria may be lost with lack of exposure. Recent heterogeneous reductions in transmission in parts of Africa mean that large populations of previously protected people may lose ...
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Open AccessComparison of allele frequencies of Plasmodium falciparum merozoite antigens in malaria infections sampled in different years in a Kenyan population
Plasmodium falciparum merozoite antigens elicit antibody responses in malaria-endemic populations, some of which are clinically protective, which is one of the reasons why merozoite an...
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Open AccessMalaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast
Targeted malaria control interventions are expected to be cost-effective. Clinical, parasitological and serological markers of malaria transmission have been used to detect malaria transmission hotspots, but f...
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Article
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
Monoclonal antibodies with broad reactivity against antigens on the parasite that causes malaria, Plasmodium falciparum, are isolated from two subjects and are found to have an unusual insertion of an immunoglobu...
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Open AccessOral versus intravenous antibiotic treatment for bone and joint infections (OVIVA): study protocol for a randomised controlled trial
Bone and joint infection in adults arises most commonly as a complication of joint replacement surgery, fracture fixation and diabetic foot infection. The associated morbidity can be devastating to patients an...
