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Article
Open AccessAnalysis of chromatin organization and gene expression in T cells identifies functional genes for rheumatoid arthritis
Genome-wide association studies have identified genetic variation contributing to complex disease risk. However, assigning causal genes and mechanisms has been more challenging because disease-associated varia...
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Article
Knowledge and Perceptions of Hepatitis B and Hepatocellular Carcinoma Screening Guidelines Among Trainees: A Tale of Three Centers
Hepatitis B (HBV), the leading cause of hepatocellular carcinoma (HCC) worldwide, disproportionately affects minorities in the USA. Undiagnosed HBV precludes HCC screening and contributes to late-stage cancer ...
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Article
Open AccessEfficacy and safety of sofosbuvir in the treatment of hep C among patients on hemodialysis: a systematic review and meta-analysis
Hepatitis C virus (HCV) infection among maintenance hemodialysis patients is implicated in increased morbidity and mortality compared to uninfected patients. Sofosbuvir (SOF)-based regimens may not be optimal ...
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Article
Open AccessMap** DNA interaction landscapes in psoriasis susceptibility loci highlights KLF4 as a target gene in 9q31
Genome-wide association studies (GWAS) have uncovered many genetic risk loci for psoriasis, yet many remain uncharacterised in terms of the causal gene and their biological mechanism in disease. This is largel...
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Article
Representations of the Necklace Braid Group: Topological and Combinatorial Approaches
The necklace braid group \({\mathcal {NB}}_n\)NBn is the motion group of the \(n+1\)n+1 component necklace link \(\mathcal {L}_n\)Ln in Euclidean \(\mathbb {R}^3\)R3. Here \(\mathcal {L}_n\)Ln consists of n pairw...
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Article
Bacterial Infection in Patients with Cirrhosis: Don’t Get Bugged to Death
Bacterial infection remains a leading cause of mortality and morbidity for patients with cirrhosis, with hospitalization, alterations in the intestinal microbiota, and therapeutic drugs all implicated in its d...
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Chapter
Virtual Infrastructure Optimisation
The increasing volumes of data being produced, curated and made available by research infrastructures in the environmental science domain require services able to optimise the delivery staging and process of d...
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Chapter
The ENVRI Reference Model
Advances in automation, communication, sensing and computation enable experimental scientific processes to generate data at increasingly great speeds and volumes. Research infrastructures are devised to take a...
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Chapter
Semantic Linking of Research Infrastructure Metadata
The use of metadata to characterise scientific datasets, making data easier to discover and use directly by researchers and via various online data services, is one of the primary concerns of research infrastr...
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Chapter
Semantic and Knowledge Engineering Using ENVRI RM
The ENVRI Reference Model provides architects and engineers with the means to describe the architecture and operational behaviour of environmental and Earth science research infrastructures (RIs) in a standard...
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Chapter
Data Cataloguing
After a brief reminder on general concepts used in data cataloguing activities, this chapter provides information concerning the architecture and design recommendations for the implementation of catalogue syst...
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Chapter
Common Challenges and Requirements
Research infrastructures available for researchers in environmental and Earth science are diverse and highly distributed; dedicated research infrastructures exist for atmospheric science, marine science, solid...
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Chapter
Data Provenance
The provenance of research data is of critical importance to the reproducibility of and trust in scientific results. As research infrastructures provide more amalgamated datasets for researchers and more integ...
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Article
Prevention and Management of HBV Infection in Patients with Chronic Kidney Disease Requiring Renal Transplantation
This review addresses clinical challenges of hepatitis B virus (HBV) infection in patients with chronic kidney disease and renal transplant recipients.
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Article
Open AccessStructure Properties of Generalized Farey graphs based on Dynamical Systems for Networks
Farey graphs are simultaneously small-world, uniquely Hamiltonian, minimally 3-colorable, maximally outerplanar and perfect. Farey graphs are therefore famous in deterministic models for complex networks. By l...
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Article
Open AccessFiat categorification of the symmetric inverse semigroup \(\textit{IS}_n\) and the semigroup \(F^*_n\)
Starting from the symmetric group \(S_n\) S ...
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Article
The Impact of Race on Survival After Hepatocellular Carcinoma in a Diverse American Population
Hepatocellular carcinoma (HCC) incidence is increasing at differential rates depending on race. We aimed to identify associations between race and survival after HCC diagnosis in a diverse American population.
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Chapter and Conference Paper
Develo**, Provisioning and Controlling Time Critical Applications in Cloud
Quality constraints on time critical applications require high-performance supporting infrastructure and sophisticated optimisation mechanisms for develo** and integrating system components. The lack of soft...
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Article
Heterogeneity of Outcomes Following Liver Transplantation for Primary Sclerosing Cholangitis: Age Matters
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Article
Open AccessPharmacokinetics and pharmacogenetics of the MEK1/2 inhibitor, selumetinib, in Asian and Western healthy subjects: a pooled analysis
Emerging data on selumetinib, a MEK1/2 inhibitor in clinical development, suggest a possible difference in pharmacokinetics (PK) between Japanese and Western patients. This pooled analysis sought to assess the...
