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Article
Open AccessDecreased miR-192 expression in peripheral blood of asthmatic individuals undergoing an allergen inhalation challenge
MicroRNAs are small non-coding RNAs that regulate gene expression at the post-transcriptional level. While they have been implicated in various diseases, the profile changes in allergen inhalation challenge ar...
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Article
Open AccessRoflumilast attenuates allergen-induced inflammation in mild asthmatic subjects
Phosphodiesterase 4 (PDE4) inhibitors increase intracellular cyclic adenosine monophosphate (cAMP), leading to regulation of inflammatory cell functions. Roflumilast is a potent and targeted PDE4 inhibitor. Th...
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Article
Open AccessOverall asthma control achieved with budesonide/formoterol maintenance and reliever therapy for patients on different treatment steps
Adjusting medication for uncontrolled asthma involves selecting one of several options from the same or a higher treatment step outlined in asthma guidelines. We examined the relative benefit of introducing bu...
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Article
Open AccessFunctional genomics of the peripheral blood response to allergen inhalation challenge
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Chapter
Mechanisms and Management of Exercise-Induced Bronchoconstriction
The term “exercise-induced asthma” has been used to describe the transient narrowing of the airways and the subsequent increase in airway resistance, which can occur during, though more commonly following, vig...
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Article
A GABAergic system in airway epithelium is essential for mucus overproduction in asthma
γ-Aminobutyric acid (GABA) is an important neurotransmitter that, through the subtype A GABA receptor (GABAAR), induces inhibition in the adult brain. Here we show that an excitatory, rather than inhibitory, GABA...
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Chapter
Future Trends in the Use of Corticosteroids in Asthma
Corticosteroids have been used to treat a variety of airway diseases since the early 1950s, following an initial study of Carryer et al. [1], who reported the benefits of oral cortisone on ragweed pollen-induc...
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Chapter
Ozone-Induced Bronchial Hyperreactivity
Ozone (03) is a powerful oxidizing agent which is classified as a “secondary air pollutant”. Secondary air pollutants are not emitted into the atmosphere but formed from subsequent atmospheric chemical reactions ...
